Results 41 to 50 of about 5,038 (137)

lncRNA BCAR4 sponges miR‑370‑3p to promote bladder cancer progression via Wnt signaling. [PDF]

Int J Mol Med, 2020
Accumulating evidence suggests that the aberrant expression of long non‑coding RNAs (lncRNAs) is involved in the initiation, development and metastasis of bladder cancer (BC). Although several differentially expressed lncRNAs have been identified via lncRNA expression profiling of BC tissues, their functions and the molecular mechanisms underlying ...
Zhang R, Wang J, Jia E, Zhang J, Liu N, Chi C.   +5 more
europepmc   +4 more sources

[Erratum] circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer. [PDF]

Int J Oncol, 2020
Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin‑resistant esophageal cancer. Three pairs of cisplatin‑resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis ...
Zou FW, Yang SZ, Li WY, Liu CY, Liu XH, Hu CH, Liu ZH, Xu S.   +7 more
europepmc   +6 more sources

circ_0023461 Silencing Protects Cardiomyocytes from Hypoxia-Induced Dysfunction through Targeting miR-370-3p/PDE4D Signaling. [PDF]

Oxid Med Cell Longev, 2021
Background. Acute myocardial infarction (AMI) is a common cardiovascular disease with high disability and mortality. Circular RNAs (circRNAs) are implicated in the pathomechanism of multiple human diseases, including AMI. This study intended to explore the function and working mechanism of a novel circRNA circ_0023461 in hypoxia‐induced cardiomyocytes.
Ren K, Li B, Jiang L, Liu Z, Wu F, Zhang Y, Liu J, Duan W.   +7 more
europepmc   +4 more sources

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation [PDF]

Biochemical Pharmacology, 2017
Cytochrome P450 2D6 (CYP2D6) participates in the metabolism of approximately 20-25% of prescribed drugs. Genetic polymorphisms influence the expression and/or activity of CYP2D6, and inter-individual differences in drug activation and elimination caused by CYP2D6 genetic variants were reported. However, little is known about the potential modulation of
Linjuan, Zeng, Yinting, Chen, Yong, Wang, Li-Rong, Yu, Bridgett, Knox, Jiwei, Chen, Tieliu, Shi, Si, Chen, Zhen, Ren, Lei, Guo, Yuanfeng, Wu, David, Liu, Kaihong, Huang, Weida, Tong, Dianke, Yu, Baitang, Ning   +15 more
openaire   +2 more sources

Wnt7a and miR-370-3p: new contributors to bladder cancer invasion

Biotarget, 2018
In eukaryotes, microRNAs (miRNAs) are central regulators of gene expression. These small noncoding RNAs are about 19–24 nucleotides long (1). miRNAs can silence gene expression by binding to a complementary sequence in the 3'-UTR of the target gene, which then triggers mRNA degradation.
Danielle, Scheunemann, Anjan K, Pradhan, Swadesh K, Das, Devanand, Sarkar, Luni, Emdad, Paul B, Fisher   +5 more
openaire   +2 more sources

Yinchenhao Decoction Protects Against Intrahepatic Cholestasis During Pregnancy Through the miR-370-3p/TM9SF4/KIT Axis. [PDF]

Biomed Res Int
Objective: The objective is to explore the potential pathogenesis and therapeutic mechanism of Yinchenhao decoction (YCHD) in intrahepatic cholestasis of pregnancy (ICP) by focusing on the regulatory role of exosomal miR‐370‐3p on target genes TM9SF4 and KIT.
Jiang H, Yu W, Tao X, Yan Q, Zhou G, Chen C, Han G.   +6 more
europepmc   +4 more sources

Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expression [PDF]

Scientific Reports, 2016
AbstractMicroRNAs (miRNA) are believed to play an important role in glioblastoma multiforme (GBM)chemotherapy. Our study aims to investigate potential miRNA biomarkers in GBM. Sixty GBM patients, which were given temozolomide (TMZ) chemotherapy and recurrent radiotherapy, were recruited.
Yong-tao Gao, Xiao-bing Chen, Hong-lin Liu   +2 more
openaire   +2 more sources

Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis. [PDF]

Am J Physiol Endocrinol Metab, 2019
Endometriosis is a gynecologic disease common among reproductive-aged women caused by the growth of endometrial tissue outside the uterus. Altered expression of numerous genes and microRNAs has been reported in endometriosis. Steroidogenic factor 1 (SF-1), an essential transcriptional regulator of multiple genes involved in estrogen biosynthesis, is ...
Hu Z, Mamillapalli R, Taylor HS.
europepmc   +3 more sources

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

Molecular Cancer, 2019
Background CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown.
Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen, Xiangqian Fang   +13 more
doaj   +1 more source

Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p [PDF]

Journal of Biological Chemistry, 2018
Once urinary bladder cancer (UBC) develops into muscle-invasive bladder cancer, its mortality rate increases dramatically. However, the molecular mechanisms of UBC invasion and metastasis remain largely unknown. Herein, using 5637 UBC cells, we generated two sublines with low (5637 NMI) and high (5637 HMI) invasive capabilities.
Xiaojing, Huang, Hongwen, Zhu, Zemin, Gao, Junzun, Li, Junlong, Zhuang, Yu, Dong, Bing, Shen, Meiqian, Li, Hu, Zhou, Hongqian, Guo, Ruimin, Huang, Jun, Yan   +11 more
openaire   +2 more sources