Results 31 to 40 of about 70 (69)

[Erratum] circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer

International Journal of Oncology, 2020
Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin‑resistant esophageal cancer. Three pairs of cisplatin‑resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis ...
Zou, Fang-Wen, Yang, Shi-Ze, Li, Wen-Ya, Liu, Chao-Yuan, Liu, Xu-Hong, Hu, Chun-Hong, Liu, Zheng-Hua, Xu, Shun   +7 more
openaire   +5 more sources

Circ_UBE2D2 Attenuates the Progression of Septic Acute Kidney Injury in Rats by Targeting miR-370-3p/NR4A3 Axis

Journal of Microbiology and Biotechnology, 2022
As circ_UBE2D2 has been confirmed to have targeted binding sites with multiple miRNAs involved in septic acute kidney injury (SAKI), efforts in this study are directed to unveiling the specific role and relevant mechanism of circ_UBE2D2 in SAKI. HK-2 cells were treated with lipopolysaccharide (LPS) to construct SAKI model in vitro. After sh-circ_UBE2D2
Huang, Yanghui, Zheng, Guangyu
openaire   +2 more sources

Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p [PDF]

Journal of Biological Chemistry, 2018
Once urinary bladder cancer (UBC) develops into muscle-invasive bladder cancer, its mortality rate increases dramatically. However, the molecular mechanisms of UBC invasion and metastasis remain largely unknown. Herein, using 5637 UBC cells, we generated two sublines with low (5637 NMI) and high (5637 HMI) invasive capabilities.
Xiaojing, Huang, Hongwen, Zhu, Zemin, Gao, Junzun, Li, Junlong, Zhuang, Yu, Dong, Bing, Shen, Meiqian, Li, Hu, Zhou, Hongqian, Guo, Ruimin, Huang, Jun, Yan   +11 more
openaire   +2 more sources

The Potential of miR-370-3p and miR-495-3p Serving as Biomarkers for Sepsis-Associated Acute Kidney Injury

Computational and Mathematical Methods in Medicine, 2022
Objective. This study is aimed at evaluating the miR-370-3p and miR-495-3p expression in the urine of patients with sepsis-associated acute kidney injury (SA-AKI) and exploring its diagnosis value in for SA-AKI. Methods. 184 sepsis invalids were collected and divided two groups (non-AKI group or AKI group) according to whether they had acute kidney ...
Wenlu Ma, Xiaomei Miao, Fangfang Xia, Chao Ruan, Dan Tao, Bing Li   +5 more
openaire   +2 more sources

miR-370-3p affects the progression of postmenopausal osteoporosis through targeting INO80

Hereditas
Abstract Background Postmenopausal osteoporosis (PMO) is acknowledged as a principal category of osteoporosis (OP). The aim of this study was to investigate the level of miR-370-3p in PMO patients and its predictive effect on osteoporosis in postmenopausal women, and to explore the molecular mechanism of miR-370-3p on
Yang, Zhen, Sheng, Yuqi, Liu, Xiangjie, Cen, Meini, Xu, Yong   +4 more
openaire   +2 more sources

circ_0013613 Promotes the recovery of spinal cord injury by regulating mir-370-3p/caspase1 to regulate neuronal pyroptosis

Acta Biochimica Polonica, 2023
Spinal cord injury (SCI) is a common disease of the central nervous system. Circular RNAs (circRNAs) play an essential role in neuron disorders. This study aimed to investigate the role and regulatory mechanism of circ_0013613 in promoting functional recovery of spinal cord injury (SCI). The mRNA and miRNA expressions were calculated by RT-QPCR.
Yong Guo, Li Ma, Zhuo Zhang
openaire   +2 more sources

Circ_0058124 Aggravates the Progression of Papillary Thyroid Carcinoma by Activating LMO4 Expression via Targeting miR-370-3p.

Cancer management and research, 2020
Thyroid cancer is the most common malignant tumor in the endocrine system. Papillary thyroid carcinoma (PTC) accounts for the vast majority of cases in this cancer. Recently, the vital role of circular RNA (circRNA) has been acknowledged in various cancers, and this study aimed to investigate the role of circ_0058124 and related mechanism of its action
Liu,Lei, Yan,Chaohui, Tao,Shudong, Wang,Hailing   +3 more
openaire   +4 more sources

CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis

Cardiovascular Therapeutics, 2022
Background. Circular RNA Transformation/Transcription Domain Associated Protein (circTRRAP, hsa_circ_0081241) was abnormally upregulated in acute myocardial infarction (AMI) patients. However, its biological role and functional mechanism in AMI remain to be researched. Methods. Human cardiomyocyte AC16 was exposed to hypoxia to induce cell injury. Cell
Yuan Zhang, Zhenggong Li, Jiao Wang, Hao Chen, Rui He, Hongkun Wu   +5 more
openaire   +3 more sources

miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4

Cells
The proliferation and maturation of hair follicles in follicular papilla cells are predominantly governed by miRNAs, which significantly influence the cell cycle, apoptosis, and proliferation. miR-370-3p has been associated with several biological processes and targets SMAD4, a crucial component in hair follicle development. Tissue expression profiling
Jiaqi Fu, Dan Wang, Wenqing Liu, Yu Qi, Caihong Zhang, Huansong Li, Jinshun Cai, Shuang Ji, Lichun Zhang, Fuliang Sun   +9 more
openaire   +3 more sources

Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway [PDF]

Cancer Biology & Therapy, 2018
To identify the significantly altered circRNAs and mRNAs in thyroid cancer, investigate their target miRNAs and determine their biological functions.The differentially expressed circRNAs, mRNAs and pathways in thyroid cancer were identified by microarray analysis and gene set enrichment analysis (GSEA). The correlative circRNAs and mRNAs were found out
Fukun, Chen, Zhiping, Feng, Jialun, Zhu, Pengjie, Liu, Chuanzhou, Yang, Rongkai, Huang, Zhiyong, Deng   +6 more
openaire   +2 more sources