Results 31 to 40 of about 5,620 (185)

lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p. [PDF]

Biomed Res Int, 2021
Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism.
Wang Y, Ding M, Yuan X, Jiao R, Zhu D, Huang W, Deng W, Liu Y.   +7 more
europepmc   +5 more sources

Wnt7a and miR-370-3p: new contributors to bladder cancer invasion

Biotarget, 2018
In eukaryotes, microRNAs (miRNAs) are central regulators of gene expression. These small noncoding RNAs are about 19–24 nucleotides long (1). miRNAs can silence gene expression by binding to a complementary sequence in the 3'-UTR of the target gene, which then triggers mRNA degradation.
Danielle, Scheunemann, Anjan K, Pradhan, Swadesh K, Das, Devanand, Sarkar, Luni, Emdad, Paul B, Fisher   +5 more
openaire   +3 more sources

Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis [PDF]

American Journal of Physiology - Endocrinology and Metabolism, 2019
Endometriosis is a gynecologic disease common among reproductive-aged women caused by the growth of endometrial tissue outside the uterus. Altered expression of numerous genes and microRNAs has been reported in endometriosis. Steroidogenic factor 1 (SF-1), an essential transcriptional regulator of multiple genes involved in estrogen biosynthesis, is ...
Ramanaiah Mamillapalli, Hugh S Taylor
exaly   +4 more sources

miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker [PDF]

Molecular Therapy: Nucleic Acids, 2018
In the last decade, microRNAs (miRs) have been described as biomarkers and therapeutic agents. Based on this finding, our aim here is to know if (1) miRNA-370-3p can be used as a biomarker associated with a favorable survival and if (2) miRNA-370-3p can ...
Arulraj Nadaradjane, Joséphine Briand, Gwenola Bougras-Cartron, Valentine Disdero, François M. Vallette, Jean-Sébastien Frenel, Pierre-François Cartron   +6 more
doaj   +5 more sources

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling [PDF]

Molecular Cancer, 2019
Background CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown.
Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen, Xiangqian Fang   +13 more
doaj   +2 more sources

Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells [PDF]

Tumor Biology, 2017
The mechanism of dsRNA-induced gene activation (RNAa) is being gradually unveiled. The plentiful evidence that it existed in mammalian species other than human demonstrated that dsRNA-mediated RNAa is a conservative phenomenon.
Chuanchang Li, Qiangqiang Ge, Jiaxuan Liu, Qingsong Zhang, Chenghe Wang, Kai Cui, Zhong Chen   +6 more
doaj   +2 more sources

MiR-370-3P inhibits proliferation of human articular chondrocytes by regulating JAK2/STAT5B signaling pathway

Di-san junyi daxue xuebao, 2021
Objective To investigate whether the non-coding single chain RNA miR-370-3P regulates the proliferation of human articular chondrocytes (HC-a) through the JAK2/STAT5B signaling pathway and to explore its potential mechanism.
CHEN Lanni, ZHANG Huijiao, XU Xuejiao, XU Ke, ZHU Min   +4 more
doaj   +2 more sources

Yinchenhao Decoction Protects Against Intrahepatic Cholestasis During Pregnancy Through the miR-370-3p/TM9SF4/KIT Axis. [PDF]

Biomed Res Int
Objective: The objective is to explore the potential pathogenesis and therapeutic mechanism of Yinchenhao decoction (YCHD) in intrahepatic cholestasis of pregnancy (ICP) by focusing on the regulatory role of exosomal miR‐370‐3p on target genes TM9SF4 and KIT.
Jiang H, Yu W, Tao X, Yan Q, Zhou G, Chen C, Han G.   +6 more
europepmc   +6 more sources

Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma. [PDF]

Mol Cancer, 2020
Abstract Background Circular RNAs (circRNAs) have been reported to have critical regulatory roles in tumor biology. However, their contribution to melanoma remains largely unknown. Methods CircRNAs derived from oncogene CD151 were detected and verified by analyzing a large ...
Wei CY, Zhu MX, Lu NH, Liu JQ, Yang YW, Zhang Y, Shi YD, Feng ZH, Li JX, Qi FZ, Gu JY.   +10 more
europepmc   +6 more sources

Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner

International Heart Journal
Targeting circular RNA has been a novel approach to preventing and limiting acute myocardial infarction (AMI). Here, we planned to investigate the role and mechanism of circ_0020887 in AMI progression.Hypoxic injury in human cardiomyocytes (AC16) was measured using cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, flow cytometry, and ...
Huiqin, Chen, Zhendong, Cheng, Meiai, Wang, Qian, Huang, Dandan, Zheng, Qiuhong, Huang, Kefeng, Cai   +6 more
openaire   +4 more sources