Endogenous and Extracellular Roles of a Tumor Suppressor miR-379-5p in Gastric Cancer.
OncologyIntroduction: MiRNAs play important roles in development of various cancers including gastric cancer. Exosomes are extracellular vesicles for translocating molecules. This study aims to investigate the tumor suppressive roles of miR-379-5p in gastric cancer, and to investigate the roles of exosomes in transporting miR-379-5p from intracellular to ...
Liu MX, Chu KM.
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mir-374-5p, mir-379-5p, and mir-503-5p Regulate Proliferation and Hypertrophic Differentiation of Growth Plate Chondrocytes in Male Rats. [PDF]
Endocrinology, 2018 Growth plate chondrocytes undergo sequential differentiation to form the resting zone, the proliferative zone (PZ), and the hypertrophic zone (HZ). The important role of microRNAs (miRNAs) in the growth plate was previously revealed by cartilage-specific ablation of Dicer, an enzyme essential for biogenesis of many miRNAs.
Jee YH +7 more
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Small RNA Sequencing Uncovers New miRNAs and moRNAs Differentially Expressed in Normal and Primary Myelofibrosis CD34+ Cells. [PDF]
PLoS ONE, 2015 Myeloproliferative neoplasms (MPN) are chronic myeloid cancers thought to arise at the level of CD34+ hematopoietic stem/progenitor cells. They include essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF).
Paola Guglielmelli +6 more
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MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis [PDF]
Cell Death and DiseaseOvarian cancer (OC) is an aggressive malignancy of the female reproductive organs, associated with a low 5-year survival rate. Emerging evidence suggests the pivotal role of microRNAs (miRNAs) in regulating chemoresistance and metastasis in OC, primarily
Devendra Shukla +10 more
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Linchuang shenzangbing zazhi, 2022 ObjectiveTo explore the effect of chikusetsu saponin Ⅳa （CHS） on high glucose-induced human renal tubular epithelial cells （HK-2） injury and examine whether or not its mechanism is correlated with the regulation of circEIF4G2 and miR-379-5p expression ...
Qin Li +3 more
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Transcriptomic analysis revealed that oar-miR-370-3p was involved in the regulation of wool fineness in Ordos fine-wool sheep. [PDF]
Front Vet SciMicroRNA (miRNA) is a prominent topic in biological research, as it plays a crucial role in regulating various physiological processes. Identifying miRNAs associated with fiber traits enhances our understanding of the complex biological mechanisms ...
Wu C +6 more
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Transcriptomics-based analysis of key genes and potential mechanism and therapeutic agents in cadmium-induced esophageal squamous cell carcinoma progression [PDF]
Scientific ReportsChronic cadmium exposure is linked to esophageal squamous cell carcinoma (ESCC) progression, treatment resistance, and poor prognosis, but its molecular mechanisms remain unclear.
Rui Zhu +8 more
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HGG-05. miR-379-5p REGULATES PROLIFERATION, MIGRATION AND INVASION IN BRAF MUTANT-GLIOBLASTOMA [PDF]
Neuro Oncol, 2018 Zhang R, Li K, Ng H.
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Kaohsiung Journal of Medical Sciences, 2022 MicroRNAs (miRNAs) are abundant in neurons and play key roles in the function and development of the nervous system. This study focuses on the function of miR‐379‐5p in neurological function recovery during ischemic stroke.
Yun Mo +4 more
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Molecular Biomedicine, 2022 Lipotoxicity induced by the overload of lipid in the liver, especially excess free cholesterol (FC), has been recognized as one of driving factors in the transition from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH).
Yunxia Dong +8 more
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