Results 51 to 60 of about 4,926 (186)

Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study. [PDF]

open access: yesPLoS ONE, 2015
OBJECTIVE:Plasma miRNAs represent potential minimally invasive biomarkers to monitor and predict outcomes from chemotherapy. The primary goal of the current study-consisting of patients with recurrent, platinum-resistant ovarian cancer-was to identify ...
Eric A Benson   +4 more
doaj   +1 more source

Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer [PDF]

open access: yes, 2015
Despite recent advances in cancer management, colorectal cancer (CRC) remains the third most common cancer and a major health-care problem worldwide. MicroRNAs have recently emerged as key regulators of cancer development and progression by targeting ...
Abdulla, MH   +7 more
core   +2 more sources

Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline [PDF]

open access: yes, 2010
<b>Objective</b>: MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding "seed" sequences within a target mRNA. Each miRNA is capable of potentially controlling hundreds of genes.
Baker, Andrew H.   +14 more
core   +1 more source

miR-532-5p is a prognostic marker and suppresses cells proliferation and invasion by targeting TWIST1 in epithelial ovarian cancer.

open access: yesEuropean review for medical and pharmacological sciences, 2018
Dysregulated miR-532-5p has been observed in epithelial ovarian cancer (EOC). However, the potential biological function and clinical significance have not been fully explained. The study aimed to investigate the prognostic value and potential role of miR-532-5p in EOC.MiR-532-5p and Twist homolog 1 (TWIST1) mRNA expression were examined using ...
Wei, H.   +4 more
openaire   +2 more sources

Identification of miRNAs in extracellular vesicles as potential diagnostic markers for pediatric epilepsy and drug-resistant epilepsy via bioinformatics analysis

open access: yesFrontiers in Pediatrics, 2023
BackgroundPediatric epilepsy (PE) is a common neurological disease. However, many challenges regarding the clinical diagnosis and treatment of PE and drug-resistant epilepsy (DRE) remain unsettled.
Yucai Ruan   +5 more
doaj   +1 more source

miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression. [PDF]

open access: yes, 2010
Cystic fibrosis (CF) is one of the most common lethal genetic diseases in which the role of microRNAs has yet to be explored. Predicted to be regulated by miR-126, TOM1 (target of Myb1) has been shown to interact with Toll-interacting protein, forming a ...
Bray, Isabella   +6 more
core   +2 more sources

MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3

open access: yesNeuropsychiatric Disease and Treatment, 2020
Xue Yan,* Dehao Zeng,* He Zhu, Yijing Zhang, Yuying Shi, Yingxiu Wu, Hongmei Tang, Detang Li Pharmaceutical Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510405, People’s ...
Yan X   +7 more
doaj  

CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis

open access: yesJournal of Hepatocellular Carcinoma, 2021
Changshan Huang, Wei Yu, Qian Wang, Tao Huang, Yuechao Ding Department of Hepato-Biliary-Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, People’s Republic of ChinaCorrespondence: Changshan ...
Huang C, Yu W, Wang Q, Huang T, Ding Y
doaj  

Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for clear cell renal cell carcinoma using integrated bioinformatics analysis.

open access: yesPLoS ONE, 2021
With the recent research development, the importance of microRNAs (miRNAs) in renal clear cell carcinoma (CCRCC) has become widely known. The purpose of this study is to screen out the potential biomarkers of renal clear cell carcinoma (CCRCC) by ...
Miaoru Han   +5 more
doaj   +1 more source

Independent effects of sham laparotomy and anesthesia on hepatic microRNA expression in rats [PDF]

open access: yes, 2014
Background: Studies on liver regeneration following partial hepatectomy (PH) have identified several microRNAs (miRNAs) that show a regulated expression pattern.
Dame, Christof   +12 more
core   +1 more source

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