Results 71 to 80 of about 229,256 (180)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 35, 24 June 2026.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Archives of Medical Science, 2019 Introduction The impact of autosomal dominant polycystic kidney disease (ADPKD) on serum microRNAs (miRNA) is unknown. Material and methods For profiling experiment we recruited 30 patients from three equinumerous groups: controls, ADPKD and ADPKD on ...
Beata Małachowska +5 more
doaj +1 more source
Altered microRNA profile during fracture healing in rats with diabetes
Journal of Orthopaedic Surgery and Research, 2020 Background MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications.
Shunsuke Takahara +11 more
doaj +1 more source
IL-4 Up-Regulates MiR-21 and the MiRNAs Hosted in the CLCN5 Gene in Chronic Lymphocytic Leukemia. [PDF]
PLoS ONE, 2015 Interleukin 4 (IL-4) induces B-cell differentiation and survival of chronic lymphocytic leukemia (CLL) cells. MicroRNAs (miRNAs) regulate mRNA and protein expression, and several miRNAs, deregulated in CLL, might play roles as oncogenes or tumor ...
Natalia Ruiz-Lafuente +8 more
doaj +1 more source
Prediction of lymphocyte‐predominant breast cancer using microRNA expression in cytology specimens
Cancer Cytopathology, Volume 134, Issue 6, June 2026.Abstract Background Tumor‐infiltrating lymphocytes are prognostic and predictive biomarkers of breast cancer; however, conventional assessment is hindered by invasiveness and subjective evaluation, limiting clinical reproducibility. This study investigated the utility of microRNA (miRNA) profiles in predicting lymphocyte‐predominant breast cancer (LPBC)
Azusa Kai +7 more
wiley +1 more source
Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
Advanced Genetics, Volume 7, Issue 2, June 2026.This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley +1 more source
Mir-434-5p mediates skin whitening and lightening [PDF]
, 2008 David TS Wu, Jack S Chen, Donald C Chang, Shi-Lung LinInstitute of Mello Biotechnology, Taipei, Taiwan, ROCAbstract: Utilization of gene silencing effectors, such as microRNA (miRNA) and small airpin RNA (shRNA), provides a powerful new strategy for ...
Shi-Lung Lin +3 more
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miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes [PDF]
, 2023 Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Huang Z, Chen L, Chen Y, Yan Y, Deng Y
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Genetics Research, 2022 Background. Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma with high heterogeneity. There is an unmet need to investigate valid indicators for the diagnosis and therapy of DLBCL. Methods.
Chunyao Li +4 more
doaj +1 more source
miR-491-5p functions as a tumor suppressor by targeting IGF2 in colorectal cancer [PDF]
, 2019 Lei Lu,* Ming Cai,* Meixia Peng, Fei Wang, Xiaofeng Zhai Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China *These authors contributed equally to this work Background: Dysregulation of ...
Lu L, Cai M, Zhai X, Wang F, Peng M
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