Results 51 to 60 of about 4,435 (163)

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

Screening and molecular mechanism research on bile microRNAs associated with chemotherapy efficacy in perihilar cholangiocarcinoma

iScience
Summary: The efficacy of hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin (OXA) and 5-fluorouracil (5-Fu) for treating advanced perihilar cholangiocarcinoma (pCCA) has been demonstrated, yet the survival benefits of HAIC for pCCA patients ...
Shijie Fu, Haizhen Du, Yuyang Dai, Kanglian Zheng, Guang Cao, Liang Xu, Yujie Zhong, Chuanxin Niu, Yan Kong, Xiaodong Wang   +9 more
doaj   +1 more source

Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience, 2018
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease. While genetics and other factors contribute to ALS pathogenesis, critical knowledge is still missing and validated biomarkers for monitoring the disease activity ...
Maria Liguori, Nicoletta Nuzziello, Alessandro Introna, Arianna Consiglio, Flavio Licciulli, Eustachio D’Errico, Antonio Scarafino, Eugenio Distaso, Isabella L. Simone   +8 more
doaj   +1 more source

Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats

Experimental Physiology, EarlyView.
Abstract Loss of ovarian hormones (i.e., menopause) leads to negative effects on metabolic health. While exercise offers significant benefits, it seems to be insufficient to completely reverse these changes. The mechanisms by which exercise conveys the effects throughout the body are still poorly understood.
Veera Puumalainen, Anni Maja, Tia‐Marje Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira Karvinen   +7 more
wiley   +1 more source

Bright and Durable Copper‐Iodide‐Based Nanowire Scintillators

Aggregate, Volume 7, Issue 8, August 2026.
A surface‐protective‐agent (SPA)‐coordinated low‐temperature crystallization strategy regulates the surface microenvironment of CsCu2I3 nanowires at the atomic level. The SPA simultaneously suppresses iodine‐vacancy‐related defects and nonradiative recombination while eliminating Cu2+ species and surface oxide formation, offering a coherent pathway to ...
Yandong Ren, Jiben Yang, Changting Wei, Zhenhuang Su, Hongda Gao, Junqiang Chai, Ci Wang, Huangxian Ju   +7 more
wiley   +1 more source

Differential Pattern of Circulating MicroRNA Expression in Patients with Intracranial Atherosclerosis

Biomedicines
Background: Intracranial atherosclerosis (ICAS) is a major cause of ischemic stroke, yet fundamental studies regarding epigenetic regulation of ICAS are lacking.
Marine M. Tanashyan, Anton A. Raskurazhev, Alla A. Shabalina, Andrey S. Mazur, Vladislav A. Annushkin, Polina I. Kuznetsova, Sergey N. Illarioshkin, Mikhail A. Piradov   +7 more
doaj   +1 more source

Metal Halide Perovskite Quantum Dots for Luminescence Sensing and Imaging

Nano Select, Volume 7, Issue 8, August 2026.
This review highlights recent advances in metal halide perovskite quantum dots (PQDs)‐based photoluminescence, chemiluminescence, and electroluminescence sensing methods, as well as bioimaging applications. Key challenges, potential solutions, and future opportunities are discussed to guide the development of robust PQD‐based sensing platforms ...
Tooba Hallaj, Rana Salari, Seyyed Morteza Seyyed Alavi, Muhammad Munir, Niko Hildebrandt, Mohammad Amjadi   +5 more
wiley   +1 more source

Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1436-1453, July 2026.
DPSCs, hepatocytes, and exosomes were tested for liver fibrosis therapy. Exosome‐based treatment exhibited superior antioxidative and regenerative effects. Liver enzymes, oxidative stress, and profibrotic markers were significantly reduced. α‐SMA, desmin, and related gene expression were downregulated.
Sahar Rahimi, Seyedeh Mahdieh Khoshnazar, Ali Derakhshani, Nader Shahrokhi   +3 more
wiley   +1 more source

Relationship Between Coronary Atheroma, Epicardial Adipose Tissue Inflammation, and Adipocyte Differentiation Across the Human Myocardial Bridge

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Inflammation in epicardial adipose tissue (EAT) may contribute to coronary atherosclerosis. Myocardial bridge is a congenital anomaly in which the left anterior descending coronary artery takes a “tunneled” course under a bridge of myocardium:
Tracey McLaughlin, Ingela Schnittger, Anna Nagy, Elizabeth Zanley, Yue Xu, Yanqiu Song, Koen Nieman, Jennifer A. Tremmel, Damini Dey, Jack Boyd, Harold Sacks   +10 more
doaj   +1 more source

Synthesis, Characterization, and Optical Properties of Undoped and Te‐Doped W(SxSe(1−x))2 and Core‐Shell WS2@W(SxSe(1−x))2 Nanotubes

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
W(SxSe1−x)2, Te:WSSe, and WS2@WSSe nanotubes were synthesized through controlled precursor composition. The W(SxSe1−x)2 and Te:WSSe nanotubes exhibit small‐diameter (<30 nm), high‐yield, and well‐defined excitonic transitions. Composition tuning via S/Se ratios increases interlayer spacing with higher Se content. The incorporation of Te remains limited
Philip Nathaniel Immanuel, Neena Prasad, Akshay Puravankara, Stepan Kusak, Rita Rosentsveig, Yishay Feldman, Anna Eden‐Kossoy, Ifat Kaplan‐Ashiri, Vojtech Kundrat, Raul Arenal, Reshef Tenne, Lena Yadgarov   +11 more
wiley   +1 more source