Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2 [PDF]
Journal of Immunology Research, 2022 Objective. Ovarian cancer (OvCa) is the most lethal gynaecological malignancy worldwide. We aimed to illustrate the potential function and molecular mechanism of exosomal microRNA-543 (miR-543) in the oncogenesis and development of OvCa.
Shupei Zhang +10 more
doaj +7 more sources
Long noncoding RNA SNHG6 promotes the malignant phenotypes of ovarian cancer cells via miR-543/YAP1 pathway [PDF]
Heliyon, 2023 The long non-coding RNA small nucleolar RNA host gene 6 (SNHG6) acts as an oncogene in several cancers, and is highly expressed in ovarian cancer. MiR-543, a tumor suppressor, was expressed lowly in ovarian cancer.
Mengya Su, Ping Huang, Qian Li
doaj +7 more sources
miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8 [PDF]
BMC Nephrology, 2022 Background Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, which can lead to renal failure and fatality. miRNAs are an important class of endogenous non-coding RNAs implicated in a wide range of biological ...
Langen Zhuang +5 more
doaj +7 more sources
LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN [PDF]
Cancer Medicine, 2020 Long intergenic nonprotein coding RNA p53‐induced transcript (LINC‐PINT) has been reported to participate in various cancers. Here, we investigated the effects of LINC‐PINT on lung cancer progression.
Shu Wang +7 more
doaj +7 more sources
Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543 [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background Rheumatoid arthritis (RA) is inflammatory arthritic disease, and circular RNA is involved in RA development. The aim of the present work is to analyze the role of circ_0002984 in the process of RA fibroblast-like synoviocytes (RAFLSs) and the ...
Jian-zuo Lu +3 more
doaj +5 more sources
Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer [PDF]
BMC GastroenterologyBackground To analyze the relationship between Helicobacter pylori (HP) infection degree and miR-155 and miR-543 expression levels in gastric cancer (GC).
Ziwei Wang +3 more
doaj +5 more sources
circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis [PDF]
Open Medicine, 2023 Circular RNA (circRNA) THBS1 has been shown to exist as an oncogene in non-small-cell lung cancer, but its role in cervical cancer is still unclear. Our experiment aimed to uncover the functions and specific mechanism of circRNA THBS1 in cervical cancer ...
Tian Rui +5 more
doaj +5 more sources
Dysregulation of miR-543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1. [PDF]
Neuropathol Appl Neurobiol, 2023 Parkinson's disease (PD) is a progressive and age‐dependent neurodegenerative disease characterised clinically by a variety of motor symptoms and cognitive impairment.
Scheper M +5 more
europepmc +9 more sources
MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in ...
Yang Du +5 more
doaj +5 more sources
ZNF281-miR-543 Feedback Loop Regulates Transforming Growth Factor-β-Induced Breast Cancer Metastasis [PDF]
Molecular Therapy: Nucleic Acids, 2020 Breast cancer is the most common malignancy, and metastasis is the main cause of cancer-associated mortality in women worldwide. Transforming growth factor-β (TGF-β) signaling, an inducer of epithelial-to-mesenchymal transition (EMT), plays an important ...
Wei Ji +4 more
doaj +6 more sources