Results 1 to 10 of about 6,191 (242)

Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2 [PDF]

Journal of Immunology Research, 2022
Objective. Ovarian cancer (OvCa) is the most lethal gynaecological malignancy worldwide. We aimed to illustrate the potential function and molecular mechanism of exosomal microRNA-543 (miR-543) in the oncogenesis and development of OvCa.
Shupei Zhang, Diling Pan, Shaoyu Zhang, Qiumei Wu, Lan Zhen, Shihuang Liu, Jingjing Chen, Rong Lin, Qiuhua Hong, Xiangqin Zheng, Huan Yi   +10 more
doaj   +4 more sources

miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. [PDF]

JCI Insight, 2020
Myelofibros is (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAK(V617F ...
Fuentes-Mattei E, Bayraktar R, Manshouri T, Silva AM, Ivan C, Gulei D, Fabris L, Soares do Amaral N, Mur P, Perez C, Torres-Claudio E, Dragomir MP, Badillo-Perez A, Knutsen E, Narayanan P, Golfman L, Shimizu M, Zhang X, Zhao W, Ho WT, Estecio MR, Bartholomeusz G, Tomuleasa C, Berindan-Neagoe I, Zweidler-McKay PA, Estrov Z, Zhao ZJ, Verstovsek S, Calin GA, Redis RS.   +29 more
europepmc   +9 more sources

Long noncoding RNA SNHG6 promotes the malignant phenotypes of ovarian cancer cells via miR-543/YAP1 pathway [PDF]

Heliyon, 2023
The long non-coding RNA small nucleolar RNA host gene 6 (SNHG6) acts as an oncogene in several cancers, and is highly expressed in ovarian cancer. MiR-543, a tumor suppressor, was expressed lowly in ovarian cancer.
Mengya Su, Ping Huang, Qian Li
doaj   +4 more sources

miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8 [PDF]

BMC Nephrology, 2022
Background Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, which can lead to renal failure and fatality. miRNAs are an important class of endogenous non-coding RNAs implicated in a wide range of biological ...
Langen Zhuang, Xiaoxu Ge, Xiaolei Hu, Qingqing Yang, Xiaoyan Pei, Guoxi Jin   +5 more
doaj   +5 more sources

circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis [PDF]

Open Medicine, 2023
Circular RNA (circRNA) THBS1 has been shown to exist as an oncogene in non-small-cell lung cancer, but its role in cervical cancer is still unclear. Our experiment aimed to uncover the functions and specific mechanism of circRNA THBS1 in cervical cancer ...
Tian Rui, Li Huixin, Ren Songjie, Li Shukui, Fang Run, Liu Yang   +5 more
doaj   +2 more sources

MiR-543 Promotes Migration, Invasion and Epithelial-Mesenchymal Transition of Esophageal Cancer Cells by Targeting Phospholipase A2 Group IVA [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: The aim of this study was to investigate the roles of miR-543 and phospholipase A2 group IVA (PLA2G4A) in cell mobility and the invasiveness cascade in esophageal squamous cell carcinoma (ESCC) and to validate the interactive ...
Huaying Zhao, Changying Diao, Xiaohui Wang, Yilin Xie, Yaqing Liu, Xianzheng Gao, Jing Han, Shenglei Li   +7 more
doaj   +3 more sources

Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543 [PDF]

Journal of Orthopaedic Surgery and Research, 2023
Background Rheumatoid arthritis (RA) is inflammatory arthritic disease, and circular RNA is involved in RA development. The aim of the present work is to analyze the role of circ_0002984 in the process of RA fibroblast-like synoviocytes (RAFLSs) and the ...
Jian-zuo Lu, Jie Yang, Sheng-tuo Zhou, Kai-luo Xie   +3 more
doaj   +2 more sources

GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer [PDF]

Mediators of Inflammation, 2023
Gastric cancer (GC) is one of the most common and lethal cancers worldwide. In view of the prominent roles of long noncoding RNAs (lncRNAs) in cancers, we investigated the specific role and underlying mechanism of GATA binding protein 6 antisense RNA 1 ...
Yi Jin, Daqing Jiang
doaj   +2 more sources

Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer [PDF]

BMC Gastroenterology
Background To analyze the relationship between Helicobacter pylori (HP) infection degree and miR-155 and miR-543 expression levels in gastric cancer (GC).
Ziwei Wang, Xinxin Zhou, Mosang Yu, Xin Hu   +3 more
doaj   +2 more sources

lncRNA FDNCR promotes apoptosis of granulosa cells by targeting the miR-543-3p/DCN/TGF-β signaling pathway in Hu sheep [PDF]

Molecular Therapy: Nucleic Acids, 2021
Long non-coding RNAs (lncRNAs) regulate the development of follicles and reproductive diseases, but the mechanisms by which lncRNAs regulate ovarian functions and fertility remain elusive.
Xiaolei Yao, XiaoXiao Gao, Yongjin Bao, M.A. El-Samahy, Jinyu Yang, Zhibo Wang, Xiaodan Li, Guomin Zhang, Yanli Zhang, Wujun Liu, Feng Wang   +10 more
doaj   +2 more sources