Results 101 to 110 of about 4,830 (194)

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

open access: yesClinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang   +3 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

open access: yesMedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi   +5 more
wiley   +1 more source

Experimental procedures to identify and validate specific mRNA targets of miRNAs [PDF]

open access: yes, 2015
Functionally matured microRNAs (miRNAs) are small single-stranded non-coding RNA molecules which are emerging as important post-transcriptional regulators of gene expression and consequently are central players in many physiological and pathological ...
Elton, Terry S., Yalowich, Jack C.
core   +1 more source

The multifaceted roles of the transcription factor SP1 in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract Alzheimer's disease (AD) is driven by interrelated pathologies, including the accumulation of amyloid β (Aβ), tau pathology, chronic neuroinflammation, and oxidative stress (OS). These pathological processes collectively lead to progressive neurodegeneration.
Zhengxiang Lv   +5 more
wiley   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

open access: yesHIV Medicine, Volume 27, Issue 4, Page 498-512, April 2026.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre   +2 more
wiley   +1 more source

Micro-RNA regulation of hepatic drug metabolism : age-related changes in micro-RNA expression and genetic variants in micro-RNA target sites [PDF]

open access: yes, 2017
Indiana University-Purdue University Indianapolis (IUPUI)Developmental changes in the liver significantly impact drug disposition. Due to the emergence of microRNAs as important regulators of drug disposition, we hypothesize that age-dependent change
Burgess, Kimberly Sherrelle
core   +1 more source

The E6 and E7 proteins of beta3 human papillomavirus 49 can deregulate both cellular and extracellular vesicles-carried microRNAs

open access: yesInfectious Agents and Cancer, 2022
Background The β3 human papillomavirus (HPV)49 induces immortalization of primary keratinocytes through the action of E6 and E7 oncoproteins with an efficiency similar to alpha high risk (HR)-HPV16.
Maria Vincenza Chiantore   +8 more
doaj   +1 more source

Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
The Mediterranean diet interacts with genetic and epigenetic backgrounds to modulate nutrigenomic mechanisms, including DNA methylation, histone modification and microRNA regulation. These molecular effects reduce inflammation and oxidative stress, enhance nitric oxide bioavailability and lipid metabolism and translate into improved cardiometabolic ...
Karina Ramírez‐Alarcón   +16 more
wiley   +1 more source

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