Results 81 to 90 of about 276,038 (194)
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, Volume 13, Issue 32, 9 June 2026.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
MiR-21-5p, miR-18a-5p, miR-27a-3p and miR-423-5p expression in AMI_T0 and CAD groups (n = 3).
, 2019 (A) MiR-21-5p expression in CAD and AMI_T0 groups. Mann-Whitney U = 196, n.s. (B) MiR-18a-5p expression in CAD and AMI_T0 groups. Mann-Whitney U = 190, n.s. (C) MiR-27a-3p expression in CAD and AMI_T0 groups. Mann-Whitney U = 106, n.s.
Ruggiero Mango (266696) +11 more
core +1 more source
The Egyptian Journal of Neurology, Psychiatry and NeurosurgeryBackground Many biomarkers have been investigated for migraine diagnosis, giving insights into the pathophysiology of migraine, treatment response, and for the development of new treatment strategies.
Hany Mohamed El Deeb +2 more
doaj +1 more source
MiR-590-5p sensitises pancreatic ductal adenocarcinoma cells by blocking autophagy via targeting ATG3 [PDF]
, 2019 Abstract Radio-resistance is a growing concern in treating patients with pancreatic cancer (PC). Here we investigated the role of miR-590-5p in the radio-resistance of PC cells. We developed radioresistant PC cell lines and followed by microarray analysis and levels of miRs compared to parental cell lines.
Li, Fazhao +4 more
openaire +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura +14 more
wiley +1 more source
OncoTargets and Therapy, 2016 The aim of this study was to determine the role of miRNA-590-5p in gastric cancer (GC) progression.Quantitative real-time polymerase chain reaction was performed to measure endogenous miR-590-5p levels in GC cells and tissues. Overexpression or knockdown of miR-590-5p in GC cells was performed by transfection with mimics or an inhibitor, respectively ...
Shen,Bo +6 more
openaire +4 more sources
, 2018 Li Chai,1 Xiao-Jing Kang,2 Zhen-Zhu Sun,3 Ming-Feng Zeng,2 Shi-Rong Yu,2 Yuan Ding,2 Jun-Qin Liang,2 Ting-Ting Li,2 Juan Zhao2 1Xinjiang Medical University, Urumqi, China; 2Department of Dermatology and Venereology, People’s Hospital of Xinjiang ...
Sun ZZ +8 more
core
, 2019 Although the cancer/testis antigen CAGE has been implicated in tumorigenesis, the molecular mechanisms of CAGE-promoted tumorigenesis remain largely unknown.
Seungheon Lee (7862393) +5 more
core +1 more source
BCL11A was a target of hsa-miR-190b-5p.
, 2023 (A) The human BCL11A mRNA 3’-UTR harbored two putative binding sites (499–506 loci: ACATATC; 2553–2559 loci: ACATATC) of hsa-miR-190b-5p. These mutant binding sites (ACATATC>TGTATAG) were shown below. (B) qRT-PCR analysis of hsa-miR-190b-5p expression in
Hailong Huang (1449589) +9 more
core +1 more source
Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease
Journal of Translational Medicine, 2018 Background Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation.
Xinxin Chen +8 more
doaj +1 more source