Results 71 to 80 of about 276,038 (194)

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

miR-149-5p mitigates tumor necrosis factor-α-induced chondrocyte apoptosis by inhibiting TRADD

, 2020
Introduction Chondrocyte apoptosis as a prominent characteristic is usually accompanied by cartilage degeneration in osteoarthritis (OA). Herein, we aimed to determine the roles of miR-149-5p in tumor necrosis factor-α (TNF-α)-induced chondrocyte ...
Shi-cheng Xie, Lin Yang, Wenbo Wang, Taipengfei Shu, Qin Liu   +4 more
core   +1 more source

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Bioinformatics predicted oar-miR-3955-5p binding sites on XLOC005698, and oar-miR-544-5p binding sites on XLOC000629.

, 2016
(a) Alignment between XLOC005698 and oar-miR-3955-5p as well as between XLOC000629 and oar-miR-544-5p. (b) The oar-miR-3955-5p miRNA binding sites on XLOC005698. (c)The oar-miR-544-5p miRNA binding sites on XLOC000629.
Tingting Guo (101831), Yaojing Yue (754892), Xiaoping Sun (55611), Jianbin Liu (754893), Jian Guo (191157), Ruilin Feng (498490), Bohui Yang (754895), Chune Niu (754894), Chao Yuan (408257)   +8 more
core   +1 more source

TFAP2A‐Induced Upregulation of LncRNA NUTM2A‐AS1 Promotes LUAD Progression Through a miR‐409‐5p/SLC35F2 Regulatory Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Long non‐coding RNAs (LncRNAs) play pivotal roles in lung adenocarcinoma (LUAD) progression. However, the upstream transcriptional regulation and downstream mechanisms of LncRNA NUTM2A‐AS1 in LUAD remain largely unexplored. The expression levels of NUTM2A‐AS1, TFAP2A, miR‐409‐5p and SLC35F2 in LUAD tissues and cell lines were analysed using ...
Weiqin Wang, Yongfeng Liu, Tiantian Chen, Jing Zhang, Feng Hu   +4 more
wiley   +1 more source

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

miR-218-5p directly targets HMGB2 and CMPK1 3'UTR.

, 2019
(A). Luciferase activity in HEK293T cells cotransfected with miR-218-5p mimic (miR-218-5p; 10 nM) or its control (NC of mimic; 10 nM) and the reporter constructs for 48 h. (B). Luciferase activity in HEK293T cells cotransfected with increasing amounts of
Qin Yan (281622), Chun Lu (107478), Wan Li (156663), Qingxia Wang (1559761), Qi Feng (227079), Shou-Jiang Gao (107475), Fei Wang (19534)   +6 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

BCL11A expression was negatively regulated by hsa-miR-190b-5p.

, 2023
(A, B) qRT-PCR and Western blot analysis of the mRNA and protein expression levels of BCL11A in 293T cells after transfected hsa-miR-190b-5p mimics and negative control mimics. β-actin gene was used as the internal control. (C) hsa-miR-190b-5p expression
Hailong Huang (1449589), Lingji Chen (15248045), Yanhong Zhang (15518), Liangpu Xu (6864014), Xinrui Wang (488330), Meihuan Chen (15456926), Yali Pan (10725749), Haiwei Wang (6864011), Min Zhang (111999), Hong Chen (108084)   +9 more
core   +1 more source

Plasma miR‑15b‑5p and miR‑590‑5p for distinguishing patients with bladder cancer from healthy individuals

Oncology Reports, 2019
MicroRNAs (miRNAs/miRs) act as markers for various cancers, including bladder cancer (BC). Plasma miRNAs are potential biomarkers for the noninvasive diagnosis and long‑term surveillance of BC. The aim of the present study was to identify diagnostically reliable miRNAs in the plasma and examine their potential monitoring capacity.
Angelika, Tölle, Laura, Buckendahl, Klaus, Jung   +2 more
openaire   +3 more sources