miRNA signature predittivo di metastasi linfonodali da carcinoma della laringe [PDF]
, 2017 The discovery that miRNAs are frequently deregulated in tumours offers the opportunity to identify them as prognostic and diagnostic markers. The aim of this multicentric study is to identify a miRNA expression profile specific for laryngeal cancer.
Abate, T. +10 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Stem cells have two important features, namely the ability for self-renewal and the capacity to differentiate into some cell kinds with specialized functions. These two features are also present in cancer stem cells (CSCs). These cells have been detected
Soudeh Ghafouri-Fard +5 more
doaj +1 more source
MicroRNAs in colorectal cancer stem cells: new regulators of cancer stemness? [PDF]
, 2012 Recently, the hypothesis that colorectal tumors originate from a subpopulation of cells called 'cancer stem cells' (CSCs) or tumor-initiating cells, which exhibit stem-like features, has been confirmed experimentally in various human cancers.
BAZAN, Viviana +9 more
core +1 more source
The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs
Stem Cell Reports, 2018 Summary: During reprogramming, telomere re-elongation is important for pluripotency acquisition and ensures the high quality of induced pluripotent stem cells (iPSCs), but the regulatory mechanism remains largely unknown.
Qidong Liu +10 more
doaj +1 more source
miR-590-5P inhibits the progression of tongue squamous cell carcinoma by targeting FasL. [PDF]
Int J Clin Exp Pathol, 2017 Xu Y, Han T, Zhu Y, Chen Q.
europepmc +2 more sources
The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression [PDF]
, 2010 BACKGROUND: We hypothesised that differences in microRNA expression profiles contribute to the contrasting natural history and clinical outcome of the two most common types of malignant germ cell tumour (GCT), yolk sac tumours (YSTs) and germinomas ...
Matthew J Murray +10 more
core +2 more sources
Identification of miR-194-5p as a potential biomarker for postmenopausal osteoporosis [PDF]
PeerJ, 2015 The incidence of osteoporosis is high in postmenopausal women due to altered estrogen levels and continuous calcium loss that occurs with aging. Recent studies have shown that microRNAs (miRNAs) are involved in the development of osteoporosis.
Jia Meng +8 more
doaj +2 more sources
A map of human microRNA variation uncovers unexpectedly high levels of variability [PDF]
, 2012 Background MicroRNAs (miRNAs) are key components of the gene regulatory network in many species. During the past few years, these regulatory elements have been shown to be involved in an increasing number and range of diseases.
Alicia Vela +13 more
core +4 more sources
Coordinated Expressional Landscape of the Human Placental miRNome and Transcriptome
Frontiers in Cell and Developmental Biology, 2021 Placenta is a unique organ that serves its own function, and contributes to maternal gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all the maternal-fetal needs across gestation is not fully understood ...
Rain Inno +3 more
doaj +1 more source
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]
, 2016 Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik +64 more
core +1 more source