miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer [PDF]
Molecular Cancer, 2014 Background While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of these drugs.
Claire Corcoran +6 more
doaj +6 more sources
Effect of miR-630 expression on esophageal cancer cell invasion and migration. [PDF]
J Clin Lab Anal, 2021 AbstractBackgroundEsophageal cancer (EC) is a common malignancy of the digestive tract, with high incidence. The objective of this study was to investigate the effect of miR‐630 expression on esophageal cancer (EC) cell invasion and migration.MethodsThe study group comprised 58 EC patients admitted to our hospital from April 2014 to 2016, and the ...
Liu X +6 more
europepmc +4 more sources
CircFAM114A2 inhibits the progression of hepatocellular carcinoma via miR‐630/HHIP axis [PDF]
Cancer Medicine, 2023 Background Many studies have shown that circular RNAs (circRNAs) are abnormally expressed in various tumor tissues and served as a key regulator in the occurrence and development of cancer.
Mingshuang Lai +11 more
doaj +2 more sources
MiR-630 suppresses non-small cell lung cancer by targeting vimentin. [PDF]
J Clin Lab Anal, 2022 AbstractObjectiveThis study aimed to clarify the function of miR‐630 on non‐small cell lung cancer (NSCLC) cells.MethodsQuantitative real‐time PCR was utilized to detect the mRNA expression of miR‐630 and vimentin (VIM) in NSCLC tissues and cells. The protein expression of VIM, P53, Caspase‐3, Bcl‐2, Bax and JAK2/STAT3 was evaluated via Western blot ...
Wang B, Li J, Li Y, Liang T, Chu X.
europepmc +3 more sources
miR-630 functions as a tumor oncogene in renal cell carcinoma. [PDF]
Arch Med Sci, 2016 MicroRNAs (miRNAs) are non-coding RNAs that regulate multiple cell processes during cancer progression. Renal cell carcinoma (RCC) is a malignancy with a poor prognosis. In this study, we aimed to investigate the roles of miR-630 in RCC progression.Expression of miR-630 was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) in four
Zhao JJ +5 more
europepmc +4 more sources
MiR-630 suppresses breast cancer progression by targeting metadherin. [PDF]
Oncotarget, 2016 MicroRNAs have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. The miR-630 was reported to be deregulated and involved in tumor progression of several human malignancies. However, its expression regulation shows diversity in different kinds of cancers and its potential roles remain greatly elusive.
Zhou CX +11 more
europepmc +3 more sources
miR-630 overexpression in hepatocellular carcinoma tissues is positively correlated with alpha-fetoprotein. [PDF]
Med Sci Monit, 2015 MicroRNA-630 (miR-630) has been shown to be involved in various human malignancies. However, its role in hepatocellular carcinoma (HCC) remains unknown.TaqMan qRT-PCR assay was performed to detect the expression of miR-630 in 42 pairs of HCC tissues and corresponding noncancerous hepatocellular tissues, and its correlations with clinicopathologic ...
Zhang JW +7 more
europepmc +4 more sources
MiR-630 Inhibits Endothelial-Mesenchymal Transition by Targeting Slug in Traumatic Heterotopic Ossification. [PDF]
Sci Rep, 2016 AbstractHeterotopic ossification (HO) is the abnormal formation of mature bone in extraskeletal soft tissues that occurs as a result of inflammation caused by traumatic injury or associated with genetic mutation. Despite extensive research to identify the source of osteogenic progenitors, the cellular origins of HO are controversial and the underlying ...
Sun Y, Cai J, Yu S, Chen S, Li F, Fan C.
europepmc +4 more sources
CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. [PDF]
Aging (Albany NY), 2017 Although CircRNA_100269 is a biomarker used to predict cancer recurrence, its expression and function in gastric cancer (GC) remain unknown. In this study, the expression of circRNA_100269 and its potential downstream miRNA targets were investigated. The molecular function and regulatory mechanism of circRNA_100269 in GC cell lines were also elucidated.
Zhang Y +8 more
europepmc +3 more sources
Expression of miR-630 associated with tyrosine kinase inhibitor therapeutic response in lung adenocarcinoma cases. [PDF]
J Thorac Dis, 2019 The published manuscript entitled “ A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop ” by Wu et al., may be beneficial for all clinicians treating lung adenocarcinomas (1) . There is paucity of reports on the role of miR-630 expression in lung cancers.
Das S.
europepmc +3 more sources