miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer [PDF]
Molecular Cancer, 2014 Background While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of these drugs.
Claire Corcoran +6 more
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Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. [PDF]
PLoS ONE, 2014 Cyclin G-associated kinase (GAK), a key player in clathrin-mediated membrane trafficking, is overexpressed in various cancer cells. Here, we report that GAK expression is positively correlated with the Gleason score in surgical specimens from prostate ...
Minami A Sakurai +11 more
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Plasma microRNA expression signature involving miR-548q, miR-630 and miR-940 as biomarkers for nasopharyngeal carcinoma detection. [PDF]
Cancer Biomark, 2018 BACKGROUND: Increasing studies have identified a series of circulating mircoRNAs (miRNAs) as biomarkers for disease detection due to their stability in the blood. The aim of the present study was to identify specific plasma miRNAs as potential biomarkers for nasopharyngeal carcinoma (NPC) detection.
Zhuo X +6 more
europepmc +3 more sources
MicroRNAs as prognostic and predictive biomarkers among chronic myeloid leukemia patients in Addis Ababa, Ethiopia [PDF]
Scientific ReportsApproximately 1.5 million people worldwide suffer from chronic myeloid leukemia (CML). MicroRNAs (miRs) are important regulators of gene expression and offer an attractive option as biomarkers for cancer detection, diagnosis, and prognosis assessment in ...
Fekadu Urgessa +8 more
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miR-630 targets LMO3 to regulate cell growth and metastasis in lung cancer. [PDF]
Am J Transl Res, 2015 MicroRNAs (miRNAs) are a class of small non-coding RNAs that play key roles in cancer development and progression. Therefore, the discovery of miRNAs may provide a new and powerful tool for understanding the mechanism of carcinogenesis. In the present study, we aimed to investigate the functional significance of miR-630 and to identify its possible ...
Song YF +5 more
europepmc +2 more sources
Correction: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer [PDF]
Molecular CancerClaire Corcoran +6 more
doaj +2 more sources
Retraction: Tumor-derived extracellular vesicles promote activation of carcinoma-associated fibroblasts and facilitate invasion and metastasis of ovarian cancer by carrying miR-630 [PDF]
Frontiers in Cell and Developmental BiologyFrontiers Editorial Office
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Editorial Expression of Concern: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer [PDF]
Molecular CancerClaire Corcoran +6 more
doaj +2 more sources
MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma [PDF]
Acta Biochimica et Biophysica Sinica, 2016 Esophageal squamous cell carcinoma (ESCC) is among the most aggressive malignancies and has a high incidence in China. MicroRNAs (miRNAs) are small endogenous RNAs that regulate multiple tumorigenic processes, including proliferation, invasion, metastasis and prognosis.
Li, Jin +6 more
openaire +2 more sources
Increased microRNA-630 expression in gastric cancer is associated with poor overall survival. [PDF]
PLoS ONE, 2014 MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the
Dake Chu +7 more
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