Targeting the miR-630/YAP1/ERK feedback loop in epidermal growth factor receptor-mutated lung adenocarcinomas. [PDF]
J Thorac Dis, 2018 Lung cancer is the most prevalent cancer type globally. Over 1.8 million new cases are diagnosed and 1.6 million deaths are reported yearly. The 5-year survival rates of lung cancer vary in different disease stages, histological types, genders and regions. Early screening, detection and treatment are helpful to improve survival rates (1).
Zhang J, Cheng ASL, Yu J, To KF, Kang W.
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Increased microRNA-630 expression in gastric cancer is associated with poor overall survival. [PDF]
PLoS ONE, 2014 MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the
Dake Chu +7 more
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Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. [PDF]
PLoS ONE, 2014 Cyclin G-associated kinase (GAK), a key player in clathrin-mediated membrane trafficking, is overexpressed in various cancer cells. Here, we report that GAK expression is positively correlated with the Gleason score in surgical specimens from prostate ...
Minami A Sakurai +11 more
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Plasma microRNA expression signature involving miR-548q, miR-630 and miR-940 as biomarkers for nasopharyngeal carcinoma detection. [PDF]
Cancer Biomark, 2018 BACKGROUND: Increasing studies have identified a series of circulating mircoRNAs (miRNAs) as biomarkers for disease detection due to their stability in the blood. The aim of the present study was to identify specific plasma miRNAs as potential biomarkers for nasopharyngeal carcinoma (NPC) detection.
Zhuo X +6 more
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MicroRNAs as prognostic and predictive biomarkers among chronic myeloid leukemia patients in Addis Ababa, Ethiopia [PDF]
Scientific ReportsApproximately 1.5 million people worldwide suffer from chronic myeloid leukemia (CML). MicroRNAs (miRs) are important regulators of gene expression and offer an attractive option as biomarkers for cancer detection, diagnosis, and prognosis assessment in ...
Fekadu Urgessa +8 more
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miR-630 targets LMO3 to regulate cell growth and metastasis in lung cancer. [PDF]
Am J Transl Res, 2015 MicroRNAs (miRNAs) are a class of small non-coding RNAs that play key roles in cancer development and progression. Therefore, the discovery of miRNAs may provide a new and powerful tool for understanding the mechanism of carcinogenesis. In the present study, we aimed to investigate the functional significance of miR-630 and to identify its possible ...
Song YF +5 more
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Plasma miRNAome Profiling Reveals Candidate Biomarkers for Low- and High-Dose Whole-Body Ionizing Radiation Exposure [PDF]
Dose-ResponseObjective MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression and remain stable in biological fluids, even under harsh conditions.
Gizelle J. Lionel +9 more
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Correction: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer [PDF]
Molecular CancerClaire Corcoran +6 more
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Editorial Expression of Concern: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer [PDF]
Molecular CancerClaire Corcoran +6 more
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MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma [PDF]
Acta Biochimica et Biophysica Sinica, 2016 Esophageal squamous cell carcinoma (ESCC) is among the most aggressive malignancies and has a high incidence in China. MicroRNAs (miRNAs) are small endogenous RNAs that regulate multiple tumorigenic processes, including proliferation, invasion, metastasis and prognosis.
Li, Jin +6 more
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