Results 21 to 30 of about 190 (178)

MiR-630 suppresses breast cancer progression by targeting metadherin

Oncotarget, 2015
MicroRNAs have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. The miR-630 was reported to be deregulated and involved in tumor progression of several human malignancies. However, its expression regulation shows diversity in different kinds of cancers and its potential roles remain greatly elusive.
Ci-Xiang, Zhou, Chen-Long, Wang, An-Lu, Yu, Qiu-Yu, Wang, Meng-Na, Zhan, Jun, Tang, Xiu-Feng, Gong, Qian-Qian, Yin, Ming, He, Jian-Rong, He, Guo-Qiang, Chen, Qian, Zhao   +11 more
openaire   +2 more sources

Tissue miR-200c-3p and circulating miR-1290 as potential prognostic biomarkers for colorectal cancer

Scientific Reports, 2022
Epithelial–mesenchymal transition (EMT)-related cancers generally elicit low immune responses. EMT is regulated by several microRNAs (miRNAs) in cancers.
Enoch Kang, Sung Cheol Jung, Soo Kyung Nam, Yujun Park, Soo Hyun Seo, Kyoung Un Park, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee   +9 more
doaj   +1 more source

CircFAM114A2 inhibits the progression of hepatocellular carcinoma via miR‐630/HHIP axis

Cancer Medicine, 2023
Background Many studies have shown that circular RNAs (circRNAs) are abnormally expressed in various tumor tissues and served as a key regulator in the occurrence and development of cancer.
Mingshuang Lai, Deyuan Li, Meiliang Liu, Ruirui Zhang, Lijun Wang, Wenyi Peng, Haotian Xu, Siqian Wu, Si Liang, Ye Gu, Aruo Nan, Xiaoyun Zeng   +11 more
doaj   +1 more source

Monocyte subpopulations display disease-specific miRNA signatures depending on the subform of Spondyloarthropathy

Frontiers in Immunology, 2023
Spondyloarthropathies (SpA) are a family of rheumatic disorders that could be divided into axial (axSpA) and peripheral (perSpA) sub-forms depending on the disease clinical presentation.
Małgorzata Stec, Marcin Czepiel, Marzena Lenart, Agata Piestrzyńska-Kajtoch, Jacek Plewka, Agnieszka Bieniek, Kazimierz Węglarczyk, Rafał Szatanek, Magdalena Rutkowska-Zapała, Zofia Guła, Anna Kluczewska, Jarosław Baran, Mariusz Korkosz, Maciej Siedlar   +13 more
doaj   +1 more source

Relationship Between Coronary Atheroma, Epicardial Adipose Tissue Inflammation, and Adipocyte Differentiation Across the Human Myocardial Bridge

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Inflammation in epicardial adipose tissue (EAT) may contribute to coronary atherosclerosis. Myocardial bridge is a congenital anomaly in which the left anterior descending coronary artery takes a “tunneled” course under a bridge of myocardium:
Tracey McLaughlin, Ingela Schnittger, Anna Nagy, Elizabeth Zanley, Yue Xu, Yanqiu Song, Koen Nieman, Jennifer A. Tremmel, Damini Dey, Jack Boyd, Harold Sacks   +10 more
doaj   +1 more source

Targeting the miR-630/YAP1/ERK feedback loop in epidermal growth factor receptor-mutated lung adenocarcinomas [PDF]

Journal of Thoracic Disease, 2018
Lung cancer is the most prevalent cancer type globally. Over 1.8 million new cases are diagnosed and 1.6 million deaths are reported yearly. The 5-year survival rates of lung cancer vary in different disease stages, histological types, genders and regions. Early screening, detection and treatment are helpful to improve survival rates (1).
Jinglin, Zhang, Alfred S L, Cheng, Jun, Yu, Ka Fai, To, Wei, Kang   +4 more
openaire   +2 more sources

microRNA-630 Regulates Underglycosylated IgA1 Production in the Tonsils by Targeting TLR4 in IgA Nephropathy

Frontiers in Immunology, 2020
IgA nephropathy (IgAN) is the most common primary glomerular disease. The characteristic pathology involves immune complexes formed by the deposition of IgA1 and underglycosylated IgA1 aggregates in the mesangial area, which may be accompanied by the ...
Chan Liu, Mu-Yao Ye, Wen-Zhe Yan, Xiao-Fei Peng, Li-Yu He, You-Ming Peng   +5 more
doaj   +1 more source

MiR‐630 suppresses non‐small cell lung cancer by targeting vimentin

Journal of Clinical Laboratory Analysis, 2022
AbstractObjectiveThis study aimed to clarify the function of miR‐630 on non‐small cell lung cancer (NSCLC) cells.MethodsQuantitative real‐time PCR was utilized to detect the mRNA expression of miR‐630 and vimentin (VIM) in NSCLC tissues and cells. The protein expression of VIM, P53, Caspase‐3, Bcl‐2, Bax and JAK2/STAT3 was evaluated via Western blot ...
Bin Wang, Jie Li, Yulin Li, Tao Liang, Xiangyang Chu   +4 more
openaire   +2 more sources

Prospects for Treatment of Idiopathic Pulmonary Fibrosis

Архивъ внутренней медицины, 2022
Idiopathic pulmonary fibrosis (IPF) is a severe, progressive lung disease of unknown etiology with an average worldwide prevalence of 15 per 100,000. According to the etiology, IPF is classified into sporadic, syndromic, and familial cases.
R. N. Mustafin
doaj   +1 more source

miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer

Molecular Cancer, 2014
Background While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of these drugs.
Claire Corcoran, Sweta Rani, Susan Breslin, Martina Gogarty, Irene M Ghobrial, John Crown, Lorraine O’Driscoll   +6 more
doaj   +1 more source