Results 61 to 70 of about 6,232 (244)

Dysregulation of circRNA-0076906 and circRNA-0134944 is Correlated with Susceptibility to Osteoporosis and Osteoporotic Fracture in Postmenopausal Females from the Chinese Han Population

Pharmacogenomics and Personalized Medicine, 2023
Weijie Yang,* Wei Zhang,* Fengqian Li, Ning Xu, Ping Sun Department of Orthopedics, Shanghai Eighth People’s Hospital, Shanghai, 200235, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ping Sun ...
Yang W, Zhang W, Li F, Xu N, Sun P
doaj  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Identification of H2O2 induced oxidative stress associated microRNAs in HLE-B3 cells and their clinical relevance to the progression of age-related nuclear cataract

BMC Ophthalmology, 2018
Background This study is aimed to screen out the microRNAs (miRNAs) associated with H2O2 induced oxidative stress in human lens epithelial B3 (HLE-B3) cell lines and investigate their relations with the progression of age-related nuclear cataract ...
Song Wang, Chenjun Guo, Mengsi Yu, Xiaona Ning, Bo Yan, Jing Zhao, Angang Yang, Hong Yan   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Differential expression of microRNAs and their messengerRNA targets in men with normal spermatogenesis versus Sertoli cell-only syndrome

Urological Science, 2017
Objective: To identify the profiling of testicular microRNAs (miRNAs) that are differentially expressed in men with normal spermatogenesis versus Sertoli cell-only syndrome (SCOS), to predict the miRNA target genes, and to determine the molecular ...
Yu Sheng Cheng, Chia Ling Chung, Chun Fu Chen, Yung Ming Lin   +3 more
doaj   +1 more source

Supplementary Figures 1-6 from miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell Death

, 2023
Supplementary Figures 1-6 from miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell ...
Guido Kroemer, Emmanuel Barillot, Philippe Dessen, Annick Harel-Bellan, Vladimir Lazar, Hugues Ripoche, Thomas Robert, Philippe Hupé, Caroline Paccard, Nicolas Servant, Alfredo Criollo, Laura Senovilla, Oliver Kepp, Ilio Vitale, Eugenia Morselli, Lorenzo Galluzzi   +15 more
openaire   +1 more source

Gene and microRNA expression predictive of tumour response in patients treated with preoperative chemoradiotherapy for rectal cancer [PDF]

, 2013
Background Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, the response to pCRT is not uniform, and there is no effective method to predict tumour response to pCRT ...
Maretto, I
core   +1 more source

microRNA Expression Profiling in Young Prostate Cancer Patients [PDF]

, 2020
MicroRNAs (miRNAs) are small, non-coding RNA molecules with multiple roles in many biological processes. Few studies have shown the molecular characteristics in younger prostate cancer (PCa) patients.
Merino, Maria J, Parra-Medina, Rafael, Pinto, Peter, Valera, Vladimir A, Walter, Beatriz A   +4 more
core   +1 more source

Predictive and Prognostic Value of Non-Coding RNA in Breast Cancer [PDF]

, 2022
For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has ...
Chahwan, Richard, Chai, Dafei, D'Angelo, Alberto, Generali, Daniele, Morris, Rachel, Roudi, Raheleh, Sobhani, Navid, Volinia, Stefano   +7 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source