Results 71 to 80 of about 6,232 (244)

Supplementary Tables 1-4 from miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell Death

, 2023
Supplementary Tables 1-4 from miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell ...
Guido Kroemer, Emmanuel Barillot, Philippe Dessen, Annick Harel-Bellan, Vladimir Lazar, Hugues Ripoche, Thomas Robert, Philippe Hupé, Caroline Paccard, Nicolas Servant, Alfredo Criollo, Laura Senovilla, Oliver Kepp, Ilio Vitale, Eugenia Morselli, Lorenzo Galluzzi   +15 more
openaire   +1 more source

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]

, 2016
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik, A Bhoumik, A Montecalvo, A Subtil, AK Bei, AT Argaw, C Barres, C Lamaze, C Lawrie, CJ Hemmer, CJ Murray, D Cifuentes, D Nantakomol, DM Patrick, DM Pegtel, DP Bartel, E Lau, E Macia, E Pongponratn, F Tabet, G Lv, G Meister, G Meister, GD Turner, GL Genrich, H Brown, H Valadi, J Baum, J Lu, J Skog, JD Arroyo, KC Vickers, KE Jackson, KM Schweitzer, KN Couper, L Song, LC Dore, LH Miller, M Bastiani, M Dreux, M Klemba, M Raab, M Trajkovski, M Zhan, MI Lin, MP Alves, MP Perron, N Regev-Rudzki, P Landry, P Pino, P Yin, PM Bauer, PY Mantel, R Jambou, R Martinelli, RM O'Connell, S Cheloufi, S Laurance, SY Chen, T Lopotova, UA Orom, V Boonpucknavig, V Combes, Y Lee, Y Zhang   +64 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Expression profiling of human milk derived exosomal microRNAs and their targets in HIV-1 infected mothers

Scientific Reports, 2020
Despite the use of antiretroviral therapy (ART) in HIV-1 infected mothers approximately 5% of new HIV-1 infections still occur in breastfed infants annually, which warrants for the development of novel strategies to prevent new HIV-1 infections in ...
Muhammad Atif Zahoor, Xiao-Dan Yao, Bethany M. Henrick, Chris P. Verschoor, Alash’le Abimiku, Sophia Osawe, Kenneth L. Rosenthal   +6 more
doaj   +1 more source

ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003

Journal of Translational Medicine, 2023
Background ND630 is believed to be a new therapy pharmacologic molecule in targeting the expression of ACACA and regulating the lipid metabolism. However, the function of ND630 in prostate cancer remains unknown.
Yu-Peng Wu, Wen-Cai Zheng, Qi Huang, Xu-Yun Huang, Fei Lin, Zhi-Bin Ke, Qi You, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue, Ning Xu   +10 more
doaj   +1 more source

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. [PDF]

, 2018
BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems.
He, Yuan, Li, Lili, Tang, Lixu, Wang, Yan, Wang, Yibin, Wang, Zhihua, Xie, Yinping, Yu, Ling, Yu, Pengcheng, Zheng, Di   +9 more
core  

Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification [PDF]

, 2020
Lopez-Rincon A, Mendoza-Maldonado L, Martinez-Archundia M, et al. Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification. Cancers.
Afd Pharmacology, Garssen, Johan, Kraneveld, Aletta D., Lopez-Rincon, Alejandro, Martinez-Archundia, Marlet, Mendoza-Maldonado, Lucero, Pharmacology, Schönhuth, Alexander, Tonda, Alberto   +8 more
core   +5 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bioinformatic analysis of the ssc-miR-146b upstream promoter region

Animal Nutrition, 2015
Sus Scrofa microRNA-146b-5p (ssc-miR-146b) was found to be one of differentially expressional microRNAs (miRNA) in our previous study. Not only it is highly expressed but also it maintains the largest up-regulated differences on the expressional level at
Xin Tao, Xiaoming Men, Ziwei Xu
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source