Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4 [PDF]
Journal of Experimental & Clinical Cancer Research, 2018 Background The aberrant expression of microRNAs (miRNAs) has emerged as important hallmarks of cancer. However, the molecular mechanisms underlying the differences of miRNA expression remain unclear.
Yue Fu +7 more
doaj +5 more sources
IGF2BP3 enhances ferroptosis resistance in colon cancer by stabilizing SLC7A11 and is regulated by miR-98-5p [PDF]
Frontiers in OncologyPurposeColon cancer remains a global health challenge with rising mortality, necessitating novel therapeutic strategies. IGF2BP3, an oncogenic RNA-binding protein, is implicated in colon cancer progression, while its role in ferroptosis regulation ...
Yaya Sun +9 more
doaj +4 more sources
miR-98-5p Alleviated Epithelial-to-Mesenchymal Transition and Renal Fibrosis via Targeting Hmga2 in Diabetic Nephropathy [PDF]
International Journal of Endocrinology, 2019 Recently, microRNAs have been recognized as crucial regulators of diabetic nephropathy (DN) development. Epithelial-to-mesenchymal transition (EMT) can play a significant role in tubulointerstitial fibrosis, and it is a hallmark of diabetic nephropathy ...
Yingchun Zhu +7 more
doaj +5 more sources
Cardiac shock wave therapy-induced exosome derived from OGD/R-treated H9c2 cells carrying miR-98-5p promote HUVECs angiogenesis [PDF]
Scientific ReportsCardiac shock wave therapy (CSWT) as an effectual therapy can activate the function of exosomes to a certain extent. Here, we attempted to examine the role of CSWT in exosome released from ischemic cardiomyocytes and its function in myocardial ischemia ...
Lizhou Wu +5 more
doaj +2 more sources
A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian Cancer [PDF]
Frontiers in Oncology, 2020 BackgroundAccumulating studies have revealed that long non-coding RNA (lncRNA) and microRNA (miRNA) contribute to ovarian cancer (OC). DSCR8 has been found to mediate hepatocellular carcinoma development, while its role in OC remains to be explored ...
Lina Dong +4 more
doaj +2 more sources
Circular RNA ERBB2 Contributes to Proliferation and Migration of Airway Smooth Muscle Cells via miR-98-5p/IGF1R Signaling in Asthma [PDF]
Journal of Asthma and Allergy, 2021 Jun-Qian Huang,1 Fang Wang,2 Long-Tao Wang,3 Yong-Mei Li,4 Jun-Li Lu,5 Jian-You Chen2 1Department of Respiratory and Critical Medicine, Qingdao Chengyang District People’s Hospital, Qingdao, Shandong, People’s Republic of China; 2Department of ...
Huang JQ +5 more
doaj +2 more sources
Serum hsa-miR-98-5p and RORC may be new biomarkers related to esophageal cancer [PDF]
Nutrition and Cancer, 2021 This study aims to use bioinformatics methods to discover new serum miRNA markers for esophageal cancer, and provide a theoretical basis for early diagnosis of esophageal cancer. We used GEO2R to analyze the differential serum miRNAs in esophageal cancer
Han Gaohua +4 more
core +5 more sources
Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease [PDF]
Biomolecules, 2021 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression.
Katrīna D. Neiburga +20 more
doaj +5 more sources
CDKN2B-AS1 participates in high glucose-induced apoptosis and fibrosis via NOTCH2 through functioning as a miR-98-5p decoy in human podocytes and renal tubular cells [PDF]
Diabetology & Metabolic Syndrome, 2021 Highlights 1. CDKN2B-AS1 was upregulated in DN and high glucose-induced HPCs and HK-2 cells. 2. Inhibition of CDKN2B-AS1 alleviated high glucose-induced apoptosis and fibrosis of HPCs and HK-2 cells. 3.
Min Xiao +5 more
doaj +2 more sources
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes. [PDF]
J Cell Commun Signal, 2023 AbstractSeveral reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we show that miR-98-5p, that is down-regulated in the circulation during diabetes, regulates hepatic gluconeogenesis and lipogenesis by targeting PPP1R15B.
Khan R, Verma AK, Datta M.
europepmc +3 more sources