Results 41 to 50 of about 1,391,786 (251)

Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, Identify Cirrhotic Patients with HCC [PDF]

PLOS ONE, 2015
The performance of circulating biomarkers for the diagnosis of hepatocellular carcinoma (HCC) is sub-optimal. In this study we tested circulating microRNAs as biomarkers for HCC in cirrhotic patients by performing a two stage study: a discovery phase conducted by microarray and a validation phase performed by qRT-PCR in an independent series of 118 ...
FORNARI, FRANCESCA, FERRACIN, MANUELA, TRERE', DAVIDE, MILAZZO, MADDALENA, MARINELLI, SARA, GALASSI, MARZIA, VENERANDI, LAURA, POLLUTRI, DANIELA, PATRIZI, CLARISSA, BORGHI, ALBERTO, Foschi, Francesco G., STEFANINI, GIUSEPPE FRANCESCO, Negrini, Massimo, BOLONDI, LUIGI, GRAMANTIERI, LAURA   +14 more
openaire   +5 more sources

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells. [PDF]

, 2017
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed \u27small RNA zipper\u27.
Chen, Yi-Han, Deng, Shengqiong, Fan, Huiming, Li, Wenshu, Liu, Cuicui, Liu, Zhongmin, Lu, Ying, Lü, Jinhui, Meng, Lingyu, Pestell, Richard G., Qiao, Jing, Wang, Guangxue, Yu, Zuoren, Zhang, Chuyi, Zhang, Yuzhen, Zhao, Qian, Zhen, Lixiao   +16 more
core   +2 more sources

MicroRNA‐661 modulates redox and metabolic homeostasis in colon cancer

Molecular Oncology, Volume 11, Issue 12, Page 1768-1787, December 2017., 2017
miR661 modulates redox homeostasis and metabolism in colon cancer. More specifically, miR661 decreases the pentose phosphate pathway and carbohydrate metabolism, which leads to a diminished tolerance to metabolic stress. This phenotype seems to be partially associated to a reduction of H6PD and PKM2.
Marta Gómez de Cedrón, Rebeca Acín Pérez, Ruth Sánchez‐Martínez, Susana Molina, Jesús Herranz, Jaime Feliu, Guillermo Reglero, Jose Antonio Enríquez, Ana Ramírez de Molina   +8 more
wiley   +1 more source

Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients [PDF]

Journal of Translational Medicine, 2013
Abstract Background Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with poor clinical outcome. Identification and development of new markers could be beneficial for the diagnosis and prognosis of GBM patients. Deregulation of microRNAs (miRNAs or miRs) is involved in GBM.
Qiu, Shuwei, Lin, Sheng, Hu, Dan, Feng, Yimin, Tan, Yang, Peng, Ying   +5 more
openaire   +4 more sources

Serum miR‐224, miR‐760, miR‐483‐5p, miR‐378 and miR‐375 as potential novel biomarkers in rheumatoid arthritis

International Journal of Clinical Practice, 2021
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease which affects various tissues and organs mainly joints. Serum microRNAs are considered a new class of non-coding RNA which plays a vital role in pathogenesis of RA.The current study was conducted on 80 RA patients and 80 healthy participants.
Omayma O. Abdelaleem, Nermeen A. Fouad, Olfat G. Shaker, Tarek I. Ahmed, Noha K. Abdelghaffar, Hanaa M. Eid, Abdelrahmaan A. Mohamed, Ahmed Magdy Elebiary, Mohamed M. Mohamed, Rania H. Mahmoud   +9 more
openaire   +2 more sources

BMP signaling in vascular diseases

FEBS Letters, Volume 586, Issue 14, Page 1993-2002, July 04, 2012., 2012
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor‐β (TGF‐β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone ...
Jie Cai, Evangelia Pardali, Gonzalo Sánchez-Duffhues, Peter ten Dijke   +3 more
wiley   +1 more source

Effects of electroacupuncture on behavioral deficits, hippocampal neuronal death and oxidative stress in rats with parkinson"s disease [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
We aimed to study electroacupuncture (EA) for its potential neuroprotection against oxidative stress, death of hippocampal neurons and behavioral deficits in rats with Parkinson"s disease (PD). PD was induced by rotenone (2 mg/kg, subcutaneous injection)
Dingding LIU, Yan YUE
doaj   +1 more source

Regulation of microRNA with food. Part 1. Food of plant origin

Zdorovʹe Rebenka, 2023
Тhe scientific review presents the mechanisms of microRNA regulation of biological processes in the human body with the help of food products of plant origin.
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

The role of miRNAs in the development of cholangiopathies. Part 1

Zdorovʹe Rebenka, 2023
The role of miRNA in the development of cholangiopathies is given in the scientific review. This article discusses the role of miRNA in primary sclerosing cholangitis and primary biliary cho­langitis.
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

Oncogenic microRNAs characterization in clear cell renal cell carcinoma [PDF]

, 2015
A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of
BELLISSIMO, TERESA, CARBONE, Antonio, DELLA ROCCA, Carlo, DI CARLO, ANGELINA, FAZI, Francesco, PALLESCHI, GIOVANNI, PASTORE, ANTONIO LUIGI, PETROZZA, Vincenzo, PORTA, NATALE   +8 more
core   +2 more sources