Results 51 to 60 of about 1,588,382 (270)

Serum miR‐224, miR‐760, miR‐483‐5p, miR‐378 and miR‐375 as potential novel biomarkers in rheumatoid arthritis

International Journal of Clinical Practice, 2021
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease which affects various tissues and organs mainly joints. Serum microRNAs are considered a new class of non-coding RNA which plays a vital role in pathogenesis of RA.The current study was conducted on 80 RA patients and 80 healthy participants.
Omayma O. Abdelaleem, Nermeen A. Fouad, Olfat G. Shaker, Tarek I. Ahmed, Noha K. Abdelghaffar, Hanaa M. Eid, Abdelrahmaan A. Mohamed, Ahmed Magdy Elebiary, Mohamed M. Mohamed, Rania H. Mahmoud   +9 more
openaire   +2 more sources

MicroRNA‐661 modulates redox and metabolic homeostasis in colon cancer

Molecular Oncology, Volume 11, Issue 12, Page 1768-1787, December 2017., 2017
miR661 modulates redox homeostasis and metabolism in colon cancer. More specifically, miR661 decreases the pentose phosphate pathway and carbohydrate metabolism, which leads to a diminished tolerance to metabolic stress. This phenotype seems to be partially associated to a reduction of H6PD and PKM2.
Marta Gómez de Cedrón, Rebeca Acín Pérez, Ruth Sánchez‐Martínez, Susana Molina, Jesús Herranz, Jaime Feliu, Guillermo Reglero, Jose Antonio Enríquez, Ana Ramírez de Molina   +8 more
wiley   +1 more source

miR-34a-/- mice are susceptible to diet-induced obesity [PDF]

, 2016
Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H., Caslake, Muriel, Collier, Andrew, Donnelly, Iona, Holmes, William, Kurowska-Stolarska, Mariola, Lavery, Christopher A., Miller, Ashley M.   +7 more
core   +1 more source

BMP signaling in vascular diseases

FEBS Letters, Volume 586, Issue 14, Page 1993-2002, July 04, 2012., 2012
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor‐β (TGF‐β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone ...
Jie Cai, Evangelia Pardali, Gonzalo Sánchez-Duffhues, Peter ten Dijke   +3 more
wiley   +1 more source

La artrodesis de las cuatro esquinas con placa circular

Revista Iberoamericana de Cirugía de la Mano, 2007
Objetivo: La artrodesis de las cuatro esquinas del carpo fue descrita inicialmente para el tratamiento del colapso avanzado del carpo e incluye la extirpación del escafoides y la fusión de los huesos semilunar, piramidal, hueso grande y ...
A. García López, L. Clavel Rojo, D. Perea Tortosa, J. Hernández López, A. Aguirre Pastor   +4 more
doaj   +1 more source

A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance [PDF]

, 2016
BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Sequential cleavage of miRNA precursors results in a ~22 nucleotide duplex of which one strand, the mature miRNA, is typically loaded into the ...
Anderson, Elizabeth, Fatkin, Diane, Humphreys, David T., Ohanian, Monique, Preiss, Thomas   +4 more
core   +1 more source

Overexpression of long non-coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR-205-EGLN2 pathway. [PDF]

, 2019
Growing evidence suggests that long non-coding RNAs NORAD and miR-205 play a significant role in regulating cancer progression and metastasis. In this study, high expression of NORAD was firstly observed in melanoma tissues and human malignant melanoma ...
Cao, Ke, Chen, Xiang, Chen, Yong, Li, Jingjing, Liu, Yan, Sun, Lichun, Tang, Jintian, Wang, Aijun, Xiong, Wei, Zhou, Jianda, Zhou, Xiao   +10 more
core   +1 more source

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

EMBO Reports, 2008
The embryonic programme ‘epithelial–mesenchymal transition’ (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc‐finger E‐box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was ...
U. Burk, Jörg Schubert, U. Wellner, O. Schmalhofer, E. Vincan, S. Spaderna, T. Brabletz   +6 more
semanticscholar   +1 more source

MicroRNA-483 amelioration of experimental pulmonary hypertension. [PDF]

, 2020
Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit.
Bai, Liang, Chen, Shanshan, Chou, Chih-Hung, Cui, Xiaopei, Fan, Fenling, Gongol, Brendan, Gu, Mingxia, He, Ming, He, Yangyang, Huang, Hsien-Da, Jing, Zhi-Cheng, Lei, Yuyang, Li, Zhao, Malhotra, Atul, Miao, Yifei, Rabinovitch, Marlene, Shen, Yuan, Shyy, John Y-J, Wang, Xiaojian, Yan, Xiaosong, Zhang, Jiao, Zhang, Jin, Zhang, Yixin   +22 more
core   +1 more source

Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

Genome Biology, 2019
BackgroundCisplatin resistance is a major challenge for advanced head and neck cancer (HNC). Understanding the underlying mechanisms and developing effective strategies against cisplatin resistance are highly desired in the clinic.
X. Qin, Haiyan Guo, Xiaoning Wang, Xueqin Zhu, Ming Yan, Xu Wang, Qin Xu, Jianbo Shi, Eryi Lu, Wantao Chen, Jianjun Zhang   +10 more
semanticscholar   +1 more source