Results 41 to 50 of about 487,200 (353)

Mechanisms of action of intranuclear microRNAs. Part 2. MicroRNA-mediated regulation of ncRNA transcriptome and alternative splicing

open access: yesZdorovʹe Rebenka, 2022
The scientific review presents the mechanisms of action of intranuclear miRNAs, namely microRNA-mediated regulation of the non-coding RNA (ncRNA) transcriptome and alternative splicing.
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

open access: yesNature Communications, 2017
Core clock genes, such asBmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to ...
Olga Barca-Mayo   +5 more
doaj   +1 more source

A novel strategy for orthogonal genetic regulation on different RNA targeted loci simultaneously

open access: yesRNA Biology, 2022
No current RNA-targeted interference tools have been reported to simultaneously up and down-regulate different gene expressions. Here we characterized an RNA-targeted genetic regulatory strategy composed of a flap endonuclease 1 (FEN1) and specific mis ...
Yongjian Guo   +9 more
doaj   +1 more source

Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration. [PDF]

open access: yes, 2012
BACKGROUND: Adaptation to chronic ethanol (EtOH) treatment of rats results in a changed functional state of the liver and greatly inhibits its regenerative ability, which may contribute to the progression of alcoholic liver disease.
Dippold, Rachael P   +4 more
core   +2 more sources

Expression of miRNA-451 and miRNA-885 in Meningiomas

open access: yesIn Vivo, 2023
Meningiomas are one of the most common intracranial tumors, accounting for 30% of the tumors of the central nervous system. MicroRNAs (miRNAs) are noncoding RNAs containing approximately 18-22 nucleotides that regulate gene expression by interfering with transcription or inhibiting translation.
Ozgur, Baran   +12 more
openaire   +3 more sources

Mechanisms of non-coding RNA-modulated alternative splicing in cancer

open access: yesRNA Biology, 2022
Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang   +6 more
doaj   +1 more source

MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients [PDF]

open access: yes, 2015
BACKGROUND: Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine.
ANTONELLI, Guido   +9 more
core   +2 more sources

The importance of training in contemporary organizations

open access: yesMенаџмент у хотелијерству и туризму, 2019
This paper describes the concepts of training and career development for employees, level of knowledge of workers, the profit that some companies had from continuous training, and the way in which an organizational psychologist, with the support of ...
Ana Slavković, Vukan Slavković
doaj   +1 more source

MicroRNA expression profile in isolated circulating tumor cells in colorectal cancer

open access: yesУспехи молекулярной онкологии, 2023
Introduction. Colorectal cancer is a frequently diagnosed disease being in the third place among oncological diseases both in incidence and mortality. Currently, researchers focus on development of more accessible and reliable biomarkers of colorectal ...
O. I. Kit   +7 more
doaj   +1 more source

First manifestation and evolution of early left ventricular dysfunction in children with Duchenne muscular dystrophy [PDF]

open access: yesThe Moldovan Medical Journal, 2021
Background: Standard pediatric cardiology examinations and echocardiography fail to discover when the cardiomyopathy will occur in patient with Duchenne muscular dystrophy (DMD). Noninvasive markers are needed to fill this gap.
Iulia Rodoman   +3 more
doaj   +1 more source

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