Results 31 to 40 of about 563,981 (384)
RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
Cells, 2020 The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to
Sarah Bajan, G. Hutvagner
semanticscholar +1 more source
Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma
Clinical Neurology and Neurosurgery, 2017 Meningiomas are among the most common intracranial tumors, accounting for 30% of all tumors of the central nervous system. Recent studies analyzing microRNA (miRNA) profiles and functions in cancer have provided valuable information about the molecular pathogenesis of several tumor types, including glioblastoma multiforme (GBM), hepatocellular ...
Katar, Salim +8 more
openaire +3 more sources
Exosomal miRNAs in tumor microenvironment
Journal of experimental & clinical cancer research : CR, 2020 Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines.
Shiming Tan +15 more
semanticscholar +1 more source
MicroRNAs in melanoma development and resistance to target therapy [PDF]
, 2017 microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio +7 more
core +1 more source
Biological functions and molecular mechanisms of LINC00961 in human cancer
All Life, 2023 Long non-coding RNAs (lncRNAs) are more than 200 bp in length and do not translate into functional proteins. They are involved in inhibiting cell growth, migration, and invasion, and in promoting apoptosis.
Kai Li +3 more
doaj +1 more source
An estimate of the total number of true human miRNAs
Nucleic Acids Research, 2019 While the number of human miRNA candidates continuously increases, only a few of them are completely characterized and experimentally validated. Toward determining the total number of true miRNAs, we employed a combined in silico high- and experimental ...
Julia Alles +11 more
semanticscholar +1 more source
The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection
Frontiers in Immunology, 2020 MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Richa Mishra +3 more
semanticscholar +1 more source
Therapeutics and Clinical Risk Management, 2021 Ai-Nian Chen, Ling-Ling Zhong, Ke-ju Ju, Hua Cao Department of Neurology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, People’s Republic of ChinaCorrespondence: Ai-Nian ChenDepartment of Neurology, The ...
Chen AN, Zhong LL, Ju K, Cao H
doaj
Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): This study aimed to evaluate the effect of SSRIs on the expression of miRNAs and their protein targets.Materials and Methods: In a 100 day open-label study of citalopram (n=25) and sertraline (n=25), levels of miRNA 16, 132, and 124 and ...
Mahnaz Ahmadimanesh +9 more
doaj +1 more source
A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature [PDF]
, 2019 Within five to ten years after radical prostatectomy (RP), approximately 15-34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR), which is defined as recurrence of serum levels of prostate-specific antigen >0.2 µg/L, indicating ...
Erbersdobler, Andreas +8 more
core +2 more sources