Results 51 to 60 of about 360,344 (284)
Cancer Management and Research, 2020 Jifeng Yu, Yingmei Li, Yue Pan, Yu Liu, Haizhou Xing, Xinsheng Xie, Dingming Wan, Zhongxing Jiang Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People’s Republic of ChinaCorrespondence: Jifeng Yu;
Yu J +7 more
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A review on miRNAs as new biomarkers for colorectal cancer [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: Since colorectal cancer does not often have phenotypic symptoms in the early stages, the study of biomarkers for the diagnosis and prognosis of the tumor is very important.
Kiyanoush Mohammadi, Reza Safaralizadeh
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Molecules, 2019 Inositol hexaphosphate (IP6), a natural dietary component, has been found as an antitumor agent by stimulating apoptosis and inhibiting cancer cell proliferation, their migration, and metastasis in diverse cancers including colon cancer.
Małgorzata Kapral +2 more
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The American Journal of Pathology, 2009 Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs). miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene expression posttranscriptionally.
Rosa, Visone, Carlo M, Croce
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The TATA-box motif and its impact on transcriptional gene regulation by miRNAs
Biomolecular Concepts, 2015 Emerging evidence suggests that components of the small RNAs pathway interact with chromatin to regulate nuclear events, such as gene transcription. However, it has recently been reported that in some cases, gene transcription regulation by cellular ...
Granados-Riveron Javier T. +1 more
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Journal of Cardiovascular Electrophysiology, 2016 miRNAs Regulate hERGBackgroundThe human ether‐a‐go‐go‐related gene (hERG) is the major molecular component of the rapidly activating delayed rectifier K+ current (Ikr). Impairment of hERG function is believed to be a mechanism causing long‐QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation of
Jiangfang, Lian +8 more
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A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons [PDF]
, 2018 Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of several types of RNAs, and its role in the pathogenesis of ALS may involve both direct effects of
Biscarini, Silvia +10 more
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Introns of plant pri‐miRNAs enhance miRNA biogenesis
EMBO reports, 2013 Plant MIR genes are independent transcription units that encode long primary miRNA precursors, which usually contain introns. For two miRNA genes, MIR163 and MIR161, we show that introns are crucial for the accumulation of proper levels of mature miRNA. Removal of the intron in both cases led to a drop‐off in the level of mature miRNAs.
Bielewicz, Dawid +7 more
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Differential expression of microRNA-206 and its target genes in pre-eclampsia [PDF]
, 2015 Objectives: Pre-eclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify novel circulating miRNAs in maternal plasma that may be ...
Akehurst, Christine +12 more
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source