Results 61 to 70 of about 563,981 (384)

A novel class of microRNA-recognition elements that function only within open reading frames. [PDF]

, 2018
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level.
A Aizer, A Helwak, A Jakymiw, A Lal, AE Pasquinelli, AJ Giraldez, Alexander Dobin, AM Duursma, AR Buskirk, AR Quinlan, B Langmead, Bing Zhou, CJ Decker, CJ Shoemaker, CJ Woolstenhulme, CP Petersen, Dehe Wang, DP Bartel, DT Humphreys, E Huntzinger, EL Nostrand Van, GB Loeb, Guangqiao Liu, H Guo, HA Meijer, HO Iwakawa, I Behm-Ansmant, I Elcheva, J Hausser, J Liu, J Liu, JH Kim, Jie Zhou, JJ Forman, JP Broughton, K Seggerson, KA O’Donnell, Kai Zhang, L Wu, Ligang Wu, M Hafner, M Kouwenhove van, M Rehmsmeier, MD Robinson, MK Doma, ML Donnelly, N Rajewsky, NT Schirle, PA Maroney, Qian Zhao, R Ishimura, R Ishimura, R Parker, Ran Cao, RS Pillai, S Bagga, S Djuranovic, S Grosswendt, S Gu, S Jonas, S Nottrott, S Takagi, SN Bhattacharyya, SW Chi, SW Eichhorn, Timothy Nilsen, TT Tat, V Presnyak, W Filipowicz, Wen Ruan, X Adiconis, Xiang-Dong Fu, Xiaorong Zhang, Y Ishigaki, Y Liao, Y Tay, Y Wang, Y Xue, Y Zhao, Ya Zhao, Yan Qin, Yu Zhou, Yuanchao Xue, Z Cai, Zhiqiang Cai, Zonggui Chen   +85 more
core   +2 more sources

Control of translation and mRNA degradation by miRNAs and siRNAs.

Genes & Development, 2006
The control of translation and mRNA degradation is an important part of the regulation of gene expression. It is now clear that small RNA molecules are common and effective modulators of gene expression in many eukaryotic cells.
M. A. Valencia-Sanchez, Jidong Liu, G. Hannon, R. Parker   +3 more
semanticscholar   +1 more source

Principles of miRNA/miRNA* function in plant MIRNA processing

Nucleic Acids Research
Abstract MicroRNAs (miRNAs) are essential regulators of gene expression, defined by their unique biogenesis, which requires the precise excision of the small RNA from an imperfect fold-back precursor. Unlike their animal counterparts, plant miRNA precursors exhibit variations in sizes and shapes.
Santiago Rosatti, Arantxa M L Rojas, Belén Moro, Irina P Suarez, Nicolas G Bologna, Uciel Chorostecki, Javier F Palatnik   +6 more
openaire   +4 more sources

Deficient Regulatory Innate Lymphoid Cells and Differential Expression of miRNAs in Acute Myeloid Leukemia Quantified by Next Generation Sequence

Cancer Management and Research, 2020
Jifeng Yu, Yingmei Li, Yue Pan, Yu Liu, Haizhou Xing, Xinsheng Xie, Dingming Wan, Zhongxing Jiang Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People’s Republic of ChinaCorrespondence: Jifeng Yu;
Yu J, Li Y, Pan Y, Liu Y, Xing H, Xie X, Wan D, Jiang Z   +7 more
doaj  

A review on miRNAs as new biomarkers for colorectal cancer [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: Since colorectal cancer does not often have phenotypic symptoms in the early stages, the study of biomarkers for the diagnosis and prognosis of the tumor is very important.
Kiyanoush Mohammadi, Reza Safaralizadeh
doaj  

Regulation of MicroRNA-155 and Its Related Genes Expression by Inositol Hexaphosphate in Colon Cancer Cells

Molecules, 2019
Inositol hexaphosphate (IP6), a natural dietary component, has been found as an antitumor agent by stimulating apoptosis and inhibiting cancer cell proliferation, their migration, and metastasis in diverse cancers including colon cancer.
Małgorzata Kapral, Joanna Wawszczyk, Ludmiła Węglarz   +2 more
doaj   +1 more source

IMC-MDA: Prediction of miRNA-disease association based on induction matrix completion

Mathematical Biosciences and Engineering, 2023
To comprehend the etiology and pathogenesis of many illnesses, it is essential to identify disease-associated microRNAs (miRNAs). However, there are a number of challenges with current computational approaches, such as the lack of "negative samples ...
Zejun Li , Yuxiang Zhang, Yuting Bai, Xiaohui Xie, Lijun Zeng   +4 more
doaj   +1 more source

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells. [PDF]

, 2017
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed \u27small RNA zipper\u27.
Chen, Yi-Han, Deng, Shengqiong, Fan, Huiming, Li, Wenshu, Liu, Cuicui, Liu, Zhongmin, Lu, Ying, Lü, Jinhui, Meng, Lingyu, Pestell, Richard G., Qiao, Jing, Wang, Guangxue, Yu, Zuoren, Zhang, Chuyi, Zhang, Yuzhen, Zhao, Qian, Zhen, Lixiao   +16 more
core   +2 more sources

MiRNAs and Cancer [PDF]

The American Journal of Pathology, 2009
Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs). miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene expression posttranscriptionally.
Rosa, Visone, Carlo M, Croce
openaire   +2 more sources

The TATA-box motif and its impact on transcriptional gene regulation by miRNAs

Biomolecular Concepts, 2015
Emerging evidence suggests that components of the small RNAs pathway interact with chromatin to regulate nuclear events, such as gene transcription. However, it has recently been reported that in some cases, gene transcription regulation by cellular ...
Granados-Riveron Javier T., Aquino-Jarquin Guillermo   +1 more
doaj   +1 more source