Results 81 to 90 of about 287,756 (317)

Identification and validation of oncologic miRNA biomarkers for Luminal A-like breast cancer [PDF]

, 2014
Introduction: Breast cancer is a common disease with distinct tumor subtypes phenotypically characterized by ER and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression, and altered miRNA expression has been ...
Wall, D, Sweeney Karl J., Michael J Kerin, Kerin Michael J., Graham Ball, Miller Nicola, Nicola Miller (84418), Ball, G, Wall Deirdre, McDermott Ailbhe M., McDermott, AM, Ailbhe M. McDermott (114313), Kerin, MJ, Deirdre Wall, Michael J. Kerin (114334), Nicola Miller, Deirdre Wall (114317), Martyn Lorcan M., Karl J. Sweeney (237846), Lorcan M Martyn, Miller, N, Ball Graham, Sweeney, KJ, Lorcan M. Martyn (517942), Graham Ball (72613), Martyn, LM, Ailbhe M McDermott, Karl J Sweeney   +27 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Database for TSSs of Human MicroRNAs [PDF]

, 2012
MicroRNAs (miRNAs) are small endogeneous non-coding RNAs of about 22nt length. These short RNAs regulate the expression of mRNAs by hybridizing with their 3'-UTRs or by translational repression.
Sanghamitra Bandyopadhyay, Malay Bhattacharyya, Malay Bhattacharyya, Sanghamitra B   +3 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

miRNAs: Whys and Wherefores of miRNA-Mediated Regulation [PDF]

Current Biology, 2005
MiRNAs are assumed to be important in animal development and physiology, but their specific roles in vivo are still poorly understood. New bioinformatic and genetic studies are setting the stage for unraveling the specific biological functions of miRNAs.
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Role of dietary phytochemicals in modulation of miRNA expression: Natural swords combating breast cancer

Asian Pacific Journal of Tropical Medicine, 2018
The National Cancer Institute had projected breast cancer (BC) as one of the topmost prevalent malignancies around the globe. In many cases, BC becomes resistant to chemotherapy, radiation and hormonal therapies.
Banzeer Ahsan Abbasi, Javed Iqbal, Tariq Mahmood, Ali Talha Khalil, Barkat Ali, Sobia Kanwal, Sayed Afzal Shah, Riaz Ahmad   +7 more
doaj   +1 more source

Research progress on plant noncoding RNAs in response to low-temperature stress

Plant Signaling & Behavior, 2022
Low temperature (LT) is an important factor limiting plant growth and distribution. Plants have evolved sophisticated adaptive mechanisms to cope with hypothermia. RNA silencing is the orchestrator of these cellular responses.
Chenmin Huo, Baowen Zhang, Ruiju Wang
doaj   +1 more source

Role of miRNAs in skeletal muscle aging [PDF]

, 2018
Yan Zheng,1,* Jian Kong,1,* Qun Li,2 Yan Wang,1 Jie Li1 1Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, Jilin, China; 2Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin ...
Zheng Y, Li J, Li Q, Kong J, Wang Y
core