Results 71 to 80 of about 563,981 (384)
miRVine: a microRNA expression atlas of grapevine based on small RNA sequencing [PDF]
, 2015 We analyzed 70 small RNA libraries, prepared from berries, inflorescences, tendrils, buds, carpels, stamens and other samples at different developmental stages.
Belli Kullan, Jayakumar +10 more
core +3 more sources
Hypothalamic stem cells control aging speed partly through exosomal miRNAs
Nature, 2017 It has been proposed that the hypothalamus helps to control ageing, but the mechanisms responsible remain unclear. Here we develop several mouse models in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1 are ablated, as we observed ...
Yalin Zhang +6 more
semanticscholar +1 more source
Journal of Cardiovascular Electrophysiology, 2016 miRNAs Regulate hERGBackgroundThe human ether‐a‐go‐go‐related gene (hERG) is the major molecular component of the rapidly activating delayed rectifier K+ current (Ikr). Impairment of hERG function is believed to be a mechanism causing long‐QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation of
Jiangfang, Lian +8 more
openaire +2 more sources
Hydrogel-Based Colorimetric Assay for Multiplexed MicroRNA Detection in a Microfluidic Device [PDF]
, 2020 Although microRNA (miRNA) expression levels provide important information regarding disease states owing to their unique dysregulation patterns in tissues, translation of miRNA diagnostics into point-of-care (POC) settings has been limited by practical ...
Doyle, Patrick S. +3 more
core +1 more source
miRNAs and NAFLD: from pathophysiology to therapy
Gut, 2019 Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of hepatic metabolism. Epigenetic mechanisms, in particular those associated with deregulation of the expressions and activities of microRNAs (miRNAs), play a major ...
M. Gjorgjieva +4 more
semanticscholar +1 more source
Introns of plant pri‐miRNAs enhance miRNA biogenesis
EMBO reports, 2013 Plant MIR genes are independent transcription units that encode long primary miRNA precursors, which usually contain introns. For two miRNA genes, MIR163 and MIR161, we show that introns are crucial for the accumulation of proper levels of mature miRNA. Removal of the intron in both cases led to a drop‐off in the level of mature miRNAs.
Bielewicz, Dawid +7 more
openaire +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence [PDF]
, 2013 Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind.
Blednov, Yuri A. +6 more
core +2 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Breast Cancer: Targets and Therapy, 2023 Jie Li,1,* Dejiao He,2,* Yajun Bi,3,* Shengxuan Liu4 1Department of Thyroid and Breast Surgery, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, 518067, People’s Republic of China; 2Department of Nephrology, Renmin Hospital of ...
Li J, He D, Bi Y, Liu S
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