Results 251 to 260 of about 208,585 (280)
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Molecular Biology, 2006
Specific repair systems are activated in response to DNA lesions. Mismatch repair protects the genome of prokaryotic and eukaryotic cells from errors arising during replication or induced by mutagenic factors. The mismatch repair system distinguishes between the newly synthesized and pattern DNA strands by the extent of methylation and checks the ...
N. V. Golyasnaya, N. A. Tsvetkova
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Specific repair systems are activated in response to DNA lesions. Mismatch repair protects the genome of prokaryotic and eukaryotic cells from errors arising during replication or induced by mutagenic factors. The mismatch repair system distinguishes between the newly synthesized and pattern DNA strands by the extent of methylation and checks the ...
N. V. Golyasnaya, N. A. Tsvetkova
+6 more sources
Eukaryotic DNA mismatch repair
Current Opinion in Genetics & Development, 1999Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2-MSH3 and MSH2-MSH6. These two complexes have different mispair recognition properties and different abilities to support MMR. Alternative models have been proposed for how these MSH complexes function in MMR.
R D, Kolodner, G T, Marsischky
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Nature Genetics, 2017
A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.
Dashiell J, Massey, Amnon, Koren
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A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.
Dashiell J, Massey, Amnon, Koren
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Annual Review of Genetics, 1999
▪ Abstract DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive ...
A B, Buermeyer +3 more
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▪ Abstract DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive ...
A B, Buermeyer +3 more
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Constitutioneel 'mismatch repair'-deficientiesyndroom
Nederlands Tijdschrift voor Geneeskunde, 2015Constitutional mismatch repair deficiency (CMMRD) syndrome is characterised by a significantly increased risk for developing cancer in childhood. It arises when both parents have a mutation in the same mismatch repair gene and pass it on to their child.
Jongmans, M.C. +5 more
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Prokaryotic DNA Mismatch Repair
2006Publisher Summary There are several scientific reviews available that deal with the multitude of molecular processes involved in repairing various DNA lesions. The chapter discusses prokaryotic DNA mismatch repair pathway. Repair of base mismatches in Escherichia coli and related bacteria is performed by two molecular yet overlapping processes: the ...
Joseph, Nimesh +2 more
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1998
Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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1998
An important property of DNA in all living cells is its ability to form an antiparallel double helix that is stabilized by Watson-Crick pairing between complementary bases. This structural concept provides the basis for templatedirected DNA dynamic processes such as replication, repair and recombination.
P. Schär, J. Jiricny
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An important property of DNA in all living cells is its ability to form an antiparallel double helix that is stabilized by Watson-Crick pairing between complementary bases. This structural concept provides the basis for templatedirected DNA dynamic processes such as replication, repair and recombination.
P. Schär, J. Jiricny
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