Results 11 to 20 of about 3,696 (214)
Hypoxia in head and neck squamous cell carcinoma [PDF]
International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012 published_or_final_versio
Chan, YW +4 more
core +2 more sources
Microenvironment and radiation therapy [PDF]
BioMed Research International, Volume 2013, Issue 1, 2013., 2012 Dependency on tumor oxygenation is one of the major features of radiation therapy and this has led many radiation biologists and oncologists to focus on tumor hypoxia.
Harada, Hiroshi +3 more
core +3 more sources
Targeting the Enhanced Sensitivity of Radiotherapy in Cancer: Mechanisms, Applications, and Challenges. [PDF]
MedComm (2020)In this review, we first introduced the current application scenarios for radiotherapy in tumor treatment, the molecular mechanisms underlying anticancer effects of radiotherapy in treatment of cancer, and the side‐effects of radiotherapy. Second, we pay attention to discuss the main types of radiosensitizers and their latest applications and ...
Zhao Y +5 more
europepmc +2 more sources
The pharmacological treatment of epilepsy in adults
Epileptic Disorders, Volume 25, Issue 5, Page 649-669, October 2023., 2023 Abstract The pharmacological treatment of epilepsy entails several critical decisions that need to be based on an individual careful risk–benefit analysis. These include when to initiate treatment and with which antiseizure medication (ASM). With more than 25 ASMs on the market, physicians have opportunities to tailor the treatment to individual ...
Torbjörn Tomson +3 more
wiley +1 more source
Low-Energy Electron-Induced Dissociation of the Radiosensitizing Agent Sanazole. [PDF]
ChempluschemEmploying mass spectrometry supported by quantum chemical calculations, electron attachment to gas‐phase and microhydrated sanazole, a hypoxic radiosensitizer, is examined. The results suggest that hydration closes and/or slows down the dissociation process and indicates that the initial mechanism of action in a reductive cell environment may be ...
Izadi F +5 more
europepmc +2 more sources
Hypoxia signaling in cancer: Implications for therapeutic interventions
MedComm, Volume 4, Issue 1, February 2023., 2023 Solid tumors gradually form a hypoxic malignant microenvironment during growth, which promotes tumor proliferation and metastasis by affecting metabolism, angiogenesis, and immune escape, and finally leads to therapeutic resistance. In recent years, hypoxia‐inducible factor inhibitors, direct targeting of hypoxic cells, and respiratory hyperoxia have ...
Yan Zhuang +5 more
wiley +1 more source
ChemPhysChem, Volume 22, Issue 23, Page 2387-2391, December 3, 2021., 2021 The kinetic competition between the NO and NO2 loss channels in 2‐Nitroimidazole ions favours the former channel at low energies (<12.76 eV). Thus, at these energies, 2‐Nitroimidazole is an exclusive NO source, unlike 4 and 5‐Nitroimidazole isomers.
Mauro Satta +8 more
wiley +1 more source
A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy
Advanced Science, Volume 8, Issue 7, April 7, 2021., 2021 Tumor‐specific ultrasound‐activated oxygen microbubbles are developed to sensitize hypoxic tumor cells for 125I brachytherapy. The microbubbles, lyophilized for storage and easily reconstituted in situ before administration, have much better stability by the addition of sulfur hexafluoride into oxygen.
Sheng Peng +10 more
wiley +1 more source
His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]
, 1988 The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M. +3 more
core +1 more source
Molecules, 2013 In this work, a sensitive analytical method to study the stability of two new series of synthesized heterocyclic compounds, the benzimidazole-4,7-diones 5 and N-oxide benzimidazole-4,7-dione derivatives 6 was established and validated. These derivatives
Katarzyna Błaszczak-Świątkiewicz +3 more
doaj +1 more source