Results 31 to 40 of about 3,696 (214)
Journal of Chemistry, Volume 2019, Issue 1, 2019., 2019 Enaminone, (2E)‐1‐[4‐(1H‐imidazol‐1‐yl) phenyl]‐4‐methylpent‐2‐en‐1‐one (II) was synthesized by refluxing 1‐[4‐(1H‐imidazol‐1‐yl) phenyl] ethan‐1‐one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent‐free condition for 12 hours. Finally, the dihydropyrimidinone derivatives containing imidazole moiety (1–15) were obtained by reacting ...
Mashooq Ahmad Bhat +5 more
wiley +1 more source
Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - In vivo experiments on the dunning rat tumor model [PDF]
, 2004 Objective: In order to expand the use of photodynamic therapy (PDT) in the treatment of prostate carcinoma (PCA), the aim of this study was to evaluate PDT by means of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX ( PPIX) in an in vivo tumor ...
Baumgartner, Reinhold +12 more
core +1 more source
Preclinical Molecular Imaging for Precision Medicine in Breast Cancer Mouse Models
Contrast Media &Molecular Imaging, Volume 2019, Issue 1, 2019., 2019 Precision and personalized medicine is gaining importance in modern clinical medicine, as it aims to improve diagnostic precision and to reduce consequent therapeutic failures. In this regard, prior to use in human trials, animal models can help evaluate novel imaging approaches and therapeutic strategies and can help discover new biomarkers.
M. F. Fiordelisi +8 more
wiley +1 more source
Molecular Oncology, Volume 10, Issue 5, Page 704-718, May 2016., 2016 Background: Rationalization of antiangiogenics requires biomarkers. Vascular re‐normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular normalization with 18F‐misonidazole ([18F]‐FMISO, a probe that detects hypoxia) PET, in response to ...
Elena Hernández-Agudo +10 more
wiley +1 more source
Stroma Targeting Nuclear Imaging and Radiopharmaceuticals
International Journal of Molecular Imaging, Volume 2012, Issue 1, 2012., 2012 Malignant transformation of tumor accompanies profound changes in the normal neighboring tissue, called tumor stroma. The tumor stroma provides an environment favoring local tumor growth, invasion, and metastatic spreading. Nuclear imaging (PET/SPECT) measures biochemical and physiologic functions in the human body.
Dinesh Shetty +3 more
wiley +1 more source
Integrating Imaging Data into Predictive Biomathematical and Biophysical Models of Cancer
International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012 While there is a mature literature on biomathematical and biophysical modeling in cancer, many of the existing approaches are not of clinical utility, as they require input data that are extremely difficult to obtain in an intact organism, and/or require a large number of assumptions on the free parameters included in the models.
Thomas E. Yankeelov +3 more
wiley +1 more source
Comparison of chemical clustering methods using graph- and fingerprint-based similarity measures [PDF]
, 2003 This paper compares several published methods for clustering chemical structures, using both graph- and fingerprint-based similarity measures. The clusterings from each method were compared to determine the degree of cluster overlap. Each method was also
Blankley, C.J. +2 more
core +1 more source
Journal of Chemistry, Volume 8, Issue 3, Page 1120-1123, 2011., 2011 In the present study we report the synthesis and antibacterial activity of a new series 2‐(1‐methyl‐4‐nitro‐1H‐imidazol‐5‐ylsulfonyl)‐1,3,4‐thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram‐negative and gram‐positive bacteria.
Bahram Letafat +3 more
wiley +1 more source
Cancer Science, Volume 115, Issue 1, Page 227-236, January 2024.Quantitative non‐hypoxic (Splatoon) maps of the tumors tested. The Splatoon maps indicate accelerated tumor reoxygenation in the tumors irradiated with neon ions. Abstract Charged particle beams induce various biological effects by creating high‐density ionization through the deposition of energy along the beam's trajectory.
Akiko Imaizumi +5 more
wiley +1 more source
Recent Advances in Image‐Guided Radiotherapy for Head and Neck Carcinoma
Journal of Oncology, Volume 2009, Issue 1, 2009., 2009 Radiotherapy has a well‐established role in the management of head and neck cancers. Over the past decade, a variety of new imaging modalities have been incorporated into the radiotherapy planning and delivery process. These technologies are collectively referred to as image‐guided radiotherapy and may lead to significant gains in tumor control and ...
Sameer K. Nath +4 more
wiley +1 more source