Oxygen dependence for chemosensitization by misonidazole [PDF]
British Journal of Cancer, 1986 Misonidazole (MISO) potentiates the cell killing effect of certain chemotherapy agents, but only under hypoxic conditions. The purpose of the present study was to define the range of oxygen concentrations over which chemosensitization by MISO takes place using mammalian cells cultured in vitro, and to compare this with the oxygen levels required for ...
L, Roizin-Towle, E J, Hall, J P, Pirro
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Role of Positron Emission Tomography in Imaging of Non-neurologic Disorders of the Head, Neck, and Teeth in Veterinary Medicine. [PDF]
, 2019 Positron Emission Tomography (PET) is an imaging technique that provides functional information, in addition to structural information obtained with computed tomography (CT).
Culp, William TN +2 more
core
In Vivo Evaluation of the Nitroimidazole‐Based Thioflavin‐T Derivatives as Cerebral Ischemia Markers
International Journal of Biomedical Imaging, Volume 2007, Issue 1, 2007., 2007 Timely imaging and accurate interpretation of cerebral ischemia are required to identify patients who might benefit from more aggressive therapy, and nuclear medicine offers a noninvasive method for demonstrating cerebral ischemia. Three nitroimidazole‐based thioflavin‐T derivatives, N‐[4‐(benzothiazol‐2‐yl)phenyl]‐3‐(4‐nitroimidazole‐1‐yl) propanamide
Taiwei Chu +4 more
wiley +1 more source
Focal Spot, Spring/Summer 1980 [PDF]
, 1980 https://digitalcommons.wustl.edu/focal_spot_archives/1026/thumbnail ...
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High resolution PET, SPECT and projection imaging in small animals [PDF]
, 2001 Positron emission tomography, single photon emission computed tomography and planar projection imaging of radioactive tracers have long been in use for detecting and diagnosing disease in human subjects.
Eckelman, William C. +5 more
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Split dose cytotoxic experiments with misonidazole [PDF]
British Journal of Cancer, 1978 The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity.
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MR imaging features of high-grade gliomas in murine models: How they compare with human disease, reflect tumor biology, and play a role in preclinical trials [PDF]
, 2011 Murine models are the most commonly used and best investigated among the animal models of HGG. They constitute an important weapon in the development and testing of new anticancer drugs and have long been used in preclinical trials. Neuroimaging methods,
Borges, A. R. +3 more
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Focal Spot, Fall/Winter 1980 [PDF]
, 1980 https://digitalcommons.wustl.edu/focal_spot_archives/1027/thumbnail ...
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Imaging tumour hypoxia with positron emission tomography. [PDF]
, 2014 Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance.
A L Harris +99 more
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Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation [PDF]
, 2017 Background: Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibitors of DNA-Damage Response (DDR)
Abdollahi, Amir +12 more
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