Results 21 to 30 of about 7,928 (167)

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Teto metabólico como indicador de capacidade de tolerância ao esforço físico: importância da capacidade oxidativa de reserva

Revista Brasileira de Educação Física e Esporte : RBEFE, 2014
Comparados com outras espécies animais, a capacidade para a resistência de seres humanos é notável. A tese dos fatores limitantes e determinantes da resistência considera variáveis como consumo máximo de oxigênio (VO2max), limiares metabólicos e economia
Benedito Pereira
doaj   +1 more source

Impact of Carvedilol on the Mitochondrial Damage Induced by Hypoxanthine and Xantine Oxidase - What Role in Myocardial Ischemia and Reperfusion? [PDF]

, 1997
Objectivo: Os efeitos cardioprotectores do carvedilol (CV) poderão ser explicados, em parte, por interacções ao nível da mitocôndria cardíaca. O objectivo deste trabalho visou o estudo do efeito protector do CV em mitocôndrias cardíacas durante ...
Oliveira, Paulo J., Rolo, Anabela P., Monteiro, Pedro, Gonçalves, Lino, Palmeira, Carlos M., Moreno, António J.   +5 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, Volume 20, Issue 5, Page 1253-1269, May 2026.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, Volume 20, Issue 5, Page 1202-1219, May 2026.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?

Arquivos de Neuro-Psiquiatria
Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) is a rare mitochondrial disorder. Diagnostic criteria for MELAS include typical manifestations of the disease: stroke-like episodes, encephalopathy, evidence of ...
Paulo José Lorenzoni, Lineu Cesar Werneck, Cláudia Suemi Kamoi Kay, Carlos Eduardo Soares Silvado, Rosana Herminia Scola   +4 more
doaj   +1 more source

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase: what role in myocardial ischemia and reperfusion? [PDF]

, 2002
OBJECTIVES: The cardioprotective effects of carvedilol (CV) may be explained in part by interactions with heart mitochondria. The objective of this work was to study the protection afforded by CV against oxidative stress induced in isolated heart ...
Gonçalves, L, Monteiro, P, Moreno, AJ, Oliveira, PJ, Palmeira, CM, Rolo, AP   +5 more
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, Volume 16, Issue 5, Page 870-884, May 2026.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Modulação transcricional de genes associados à fosforilação oxidativa em genótipos contrastantes de feijão-caupi submetidos à desidratação radicular. [PDF]

, 2013
Mitocôndrias são conhecidas como as "estações energéticas" da célula. Elas abrigam o processo de fosforilação oxidativa, através do qual o transporte de elétrons por meio de carreadores é acoplado ao bombeamento de prótons para o espaço intermembranar ...
BENKO-ISEPPON, A. M., BRONDANI, R. P. V., COSTA, M. M. R., FERREIRA NETO, J. R. C., KIDO, É. A., NEPOMUCENO, A. L., PANDOLFI, V., SILVA, K. J. D. e, SILVA, R. L. de O.   +8 more
core   +2 more sources

Bioquímica da esquistossomose mansônica: V - atividade mitocondrial em fígados e rins de sagüis (Callitrix penicillata) infestados pelo Schistosoma mansoni Biochemistry of mansonic schistosomiasis: V - mitochondrial activity in livers and kidneys of marmosets (Callitrix penicillata) infected with Schistosoma mansoni

Revista de Saúde Pública, 1983
Foram estudadas mitocôndrias isoladas de fígados e rins de sagüis (Callitrix penicillata) infestados pela inoculação de 200 cercárias e entre 80 e 100 dias de infecção, nos aspectos relativos às suas atividades respiratórias endógenas, bem como frente ao
Luiz Erlon A. Rodrigues, Maria de Fátima D. Costa, Roberto José M. Nascimento, Túlio Miráglia   +3 more
doaj   +1 more source