Results 21 to 30 of about 1,734 (156)

Teto metabólico como indicador de capacidade de tolerância ao esforço físico: importância da capacidade oxidativa de reserva

Revista Brasileira de Educação Física e Esporte : RBEFE, 2014
Comparados com outras espécies animais, a capacidade para a resistência de seres humanos é notável. A tese dos fatores limitantes e determinantes da resistência considera variáveis como consumo máximo de oxigênio (VO2max), limiares metabólicos e economia
Benedito Pereira
doaj   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Rol de la función mitocondrial en el corazón y sus implicaciones en disfunciones cardíacas

Ingeniería y Ciencia, 2017
En este artículo de revisión, examinamos el papel de la mitocondria en el buen funcionamiento del corazón, y en la generación de diversas afecciones cardíacas, las cuales están caracterizadas por una baja producción de energía por parte de las ...
Mariana Cañas Arboleda, Nicolás D Franco-Sierra   +1 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, Volume 600, Issue 19, Page 2876-2898, October 2026.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, Volume 16, Issue 10, Page 1958-1973, October 2026.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Optimization and sensitivity analysis of fast ethanol assay in maize seeds

Journal of Seed Science
: The evaluation of seed deterioration is very important to control the quality of the seeds stored. This study aimed to investigate the potential of fast ethanol assay for seed quality assessment of maize stored under different conditions.
Damrongvudhi Onwimol, Thunyapuk Rongsangchaicharean, Pitipong Thobunluepop, Tanapon Chaisan, Wanchai Chanprasert   +4 more
doaj   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, Volume 293, Issue 19, Page 5952-5966, October 2026.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source

Bioquímica da esquistossomose mansônica: V - atividade mitocondrial em fígados e rins de sagüis (Callitrix penicillata) infestados pelo Schistosoma mansoni Biochemistry of mansonic schistosomiasis: V - mitochondrial activity in livers and kidneys of marmosets (Callitrix penicillata) infected with Schistosoma mansoni

Revista de Saúde Pública, 1983
Foram estudadas mitocôndrias isoladas de fígados e rins de sagüis (Callitrix penicillata) infestados pela inoculação de 200 cercárias e entre 80 e 100 dias de infecção, nos aspectos relativos às suas atividades respiratórias endógenas, bem como frente ao
Luiz Erlon A. Rodrigues, Maria de Fátima D. Costa, Roberto José M. Nascimento, Túlio Miráglia   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, Volume 16, Issue 9, Page 1801-1812, September 2026.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?

Arquivos de Neuro-Psiquiatria
Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) is a rare mitochondrial disorder. Diagnostic criteria for MELAS include typical manifestations of the disease: stroke-like episodes, encephalopathy, evidence of ...
Paulo José Lorenzoni, Lineu Cesar Werneck, Cláudia Suemi Kamoi Kay, Carlos Eduardo Soares Silvado, Rosana Herminia Scola   +4 more
doaj   +1 more source