Results 31 to 40 of about 7,928 (167)

Mitochondria: role in ischemia, reperfusion and cell death [PDF]

open access: yes, 2003
Recent advances in the knowledge of the biochemical basis of myocardial ischemia have enabled a better understanding of the complex sequence of events occurring in ischemic cardiomyopathy, whatever its manifestations.
Gonçalves, L, Monteiro, P, Oliveira, PJ
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Diabetes mellitus associate with the mitochondrial mutation A3243G [PDF]

open access: yes, 2006
BV UNIFESP: Teses e ...
Salles, João Eduardo Nunes
core  

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Nicorandil preserves the function of the mitochondrial phosphorylative and oxidative system in an animal model of global ischemia-reperfusion [PDF]

open access: yes, 2007
Ischemia followed by reperfusion (IR) negatively affects mitochondrial function. At the level of the oxidative-phosphorylative system, IR inhibits the respiratory complexes and ATP synthase, and increases the passive leak of protons through the inner ...
Carreira, R   +3 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, Volume 20, Issue 4, Page 1061-1073, April 2026.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Mitochondrial ultrastructural and atpase changes during the life cycle of Ascaris Suum

open access: yesMemorias do Instituto Oswaldo Cruz, 1982
Ultrastructural morphology and ATPase specific activities of mitochondria isolated from 1-celled fertilized egg, 10-day embryo, 21-day infective larvae and adult body wall muscle of Ascaris suum and rat liver were determined and compared.
G. E. Rodrick   +3 more
doaj   +1 more source

Potencial terapêutico da cymbopogon citratus na leucemia promielocítica aguda [PDF]

open access: yes, 2013
Trabalho final de mestrado integrado em medicina área científica de Biologia Celular e Molecular Aplicada/Hemato-Oncologia, apresentada á Faculdade de Medicina da Universidade de CoimbraA Cymbopogon citratus é uma planta nativa da Índia e as suas folhas ...
Santos, Rui Miguel Carvalho
core  

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

open access: yesThe FEBS Journal, Volume 293, Issue 7, Page 2086-2097, April 2026.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos   +4 more
wiley   +1 more source

Biossíntese e degradação de Lipídios, Carboidratos e Proteínas em oleaginosas. [PDF]

open access: yes, 2011
Fisiologia vegetal; Metabolismo vegetal;bitstream/CNPA/21023/1/DOC178 ...
BELTRÃO, N. E. de M.   +1 more
core  

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