Results 1 to 10 of about 2,143,033 (262)

Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease

Scientific Reports, 2021
Giant mitochondria are peculiarly shaped, extremely large mitochondria in hepatic parenchymal cells, the internal structure of which is characterised by atypically arranged cristae, enlarged matrix granules and crystalline inclusions.
Gerald J. Shami, Delfine Cheng, Pauline Verhaegh, Ger Koek, Eddie Wisse, Filip Braet   +5 more
doaj   +2 more sources

Mitotherapy for Fatty Liver by Intravenous Administration of Exogenous Mitochondria in Male Mice

Frontiers in Pharmacology, 2017
Mitochondrial dysfunction is a major and common mechanism in developing non-alcoholic fatty liver disease (NAFLD). Replacement of dysfunctional mitochondria by functional exogenous mitochondria may attenuate intrahepatic excessive lipid and recover ...
Ailing Fu, Xianxun Shi, Huajing Zhang, Bin Fu   +3 more
doaj   +2 more sources

Systems proteomics of liver mitochondria function [PDF]

Science, 2016
Expanded proteomic analysis of metabolism Combined analysis of large data sets characterizing genes, transcripts, and proteins can elucidate biological functions and disease processes. Williams et al.
Evan G. Williams, Yibo Wu, Pooja Jha, S. Dubuis, P. Blattmann, Carmen A. Argmann, S. Houten, Tiffany Amariuta, W. Wolski, Nicola Zamboni, R. Aebersold, J. Auwerx   +11 more
semanticscholar   +4 more sources

Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

Nature Communications
Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear ...
Jun Dong, Li Chen, Fei Ye, Junhui Tang, Bing Liu, Jiacheng Lin, Pang-Hu Zhou, Bin Lu, Min Wu, Jia-Hong Lu, Jing-Jing He, Simone Engelender, Qingtao Meng, Zhiyin Song, He He   +14 more
doaj   +2 more sources

Healthy mitochondria attenuate metabolic dysfunction-associated steatohepatitis by restoring cell metabolism [PDF]

Molecular Biomedicine
Metabolic dysfunction-associated steatohepatitis (MASH) has become a major global health issue. Mitochondrial damage plays a crucial role in the development and progression of MASH.
Peiyu Zhou, Jingli Li, Yafang Xie, Xiaorong Li, Zhihong Cui, Ailing Fu   +5 more
doaj   +2 more sources

Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?

International Journal of Molecular Sciences, 2021
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and represents the hepatic expression of several metabolic abnormalities of high epidemiologic relevance.
A. Di Ciaula, S. Passarella, Harshitha Shanmugam, M. Noviello, L. Bonfrate, D. Q. Wang, P. Portincasa   +6 more
semanticscholar   +1 more source

The Role of Mitochondria in Liver Ischemia-Reperfusion Injury: From Aspects of Mitochondrial Oxidative Stress, Mitochondrial Fission, Mitochondrial Membrane Permeable Transport Pore Formation, Mitophagy, and Mitochondria-Related Protective Measures

Oxidative Medicine and Cellular Longevity, 2021
Ischemia-reperfusion injury (IRI) has indeed been shown as a main complication of hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of studies have confirmed that microvascular and parenchymal damage is mainly caused by ...
Haifeng Zhang, Qi Yan, Xuan Wang, Xin Chen, Ying Chen, Jian Du, Lijian Chen   +6 more
semanticscholar   +1 more source

Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases

FEBS Letters, 2021
Calcium (Ca2+) is a second messenger essential for cellular homeostasis. Inside the cell, Ca2+ is compartmentalized and exchanged among organelles in response to both external and internal stimuli.
Chaonan Jin, P. Kumar, J. Gracia‐Sancho, J. Dufour   +3 more
semanticscholar   +1 more source

Swimming training induces liver mitochondrial adaptations to oxidative stress in rats submitted to repeated exhaustive swimming bouts. [PDF]

PLoS ONE, 2013
Background and aimsAlthough acute exhaustive exercise is known to increase liver reactive oxygen species (ROS) production and aerobic training has shown to improve the antioxidant status in the liver, little is known about mitochondria adaptations to ...
Frederico D Lima, Daniel N Stamm, Iuri D Della-Pace, Fernando Dobrachinski, Nélson R de Carvalho, Luiz Fernando F Royes, Félix A Soares, João B Rocha, Javier González-Gallego, Guilherme Bresciani   +9 more
doaj   +1 more source

Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury

Biomedicines, 2023
Liver ischemia-reperfusion injury (LIRI) is a major cause of the development of complications in different clinical settings such as liver resection and liver transplantation.
Ivo F. Machado, Carlos M. Palmeira, Anabela P. Rolo   +2 more
doaj   +1 more source