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The lifecycle of skeletal muscle mitochondria in obesity
Obesity Reviews, 2021SummarySkeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation in cellular energy transduction to meet the demands of the organism. Obesity elicits changes in skeletal muscle structure and function, resulting in the accumulation of intramuscular lipids.
Chantal A. Pileggi +2 more
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Protonmotive force in muscle mitochondria
Muscle & Nerve, 1982AbstractThe protonmotive force (Δp) of muscle mitochondria was measured by estimating the distribution of 14C‐labeled TPMP (trimethylphenylphosphonium iodide) and 14C‐labeled acetate across the inner membrane of muscle mitochondria. The matrix volume was simultaneously determined using 3H‐labeled H2O and 3H‐labeled mannitol and repeated drying to ...
D A, Stumpf +4 more
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Muscle Mitochondria Investigation in Myotonic Dystrophy
European Neurology, 2008Mitochondrial abnormalities have been previously reported in some patients with myotonic dystrophy (DM). The aim of the present paper was to study muscle mitochondria in 32 DM patients by morphological, biochemical (when suggested by morphology) and genetic analysis.
VITA, Giuseppe +7 more
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Mitochondria in muscle cell death
Neurological Sciences, 1999Mitochondria, the main source of energy for eukaryotic cells through oxidative phosphorylation, also play a key role in the pathways to cell death. The mode of cell death may be influenced by the availability of ATP, and its very occurrence may critically depend on release of mitochondrial proteins like cytochrome c, apoptosis-inducing factor and ...
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Skeletal muscle mitochondria in health and disease
Cell Calcium, 2021Mitochondrial activity warrants energy supply to oxidative myofibres to sustain endurance workload. The maintenance of mitochondrial homeostasis is ensured by the control of fission and fusion processes and by the mitophagic removal of aberrant organelles.
De Mario A. +3 more
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Mitochondria: Muscle Morphology
2019Mitochondrial genetic defects can potentially affect any cell, tissue, and organ; however, they are often referred to as mitochondrial encephalomyopathies to indicate that skeletal muscle and brain tissue, due to their high energy demand, are most often involved.
Monica Sciacco +4 more
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Effects of propranolol on heart muscle mitochondria
Biochemical Pharmacology, 1972Abstract The effects of propranolol on oxidative phosphorylation and oxidation of succinate, α-ketoglutarate, glutamate and l -malate coupled with pyruvate by rat heart mitochondria were studied. Oxidative phosphorylation and oxidation of NAD + -linked substrates by heart mitochondria were depressed by 1.44 × 10 −3 M propranolol.
A, Sakurada +3 more
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Familial Myopathy With Abnormal Muscle Mitochondria
Archives of Neurology, 1968DURING the past ten years several myopathies with unusual microscopic changes in muscle have been described. 1-3 Shy and Magee presented the original report of a familial myopathy, "central core disease," characterized by weakness and hypotonia from birth and a characteristic morphologic abnormality in the center of muscle fibers.
A N, D'Agostino +3 more
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The role of mitochondria in aging of skeletal muscle
Biogerontology, 2008Aging can be characterized as a time dependent decline of maximal functionality that affects tissues and organs of the whole body. Such is induced by the progressive loss of redundant components and leads to an increased susceptibility to disease and risk of death.
Figueiredo, Pedro Alexandre +3 more
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