Results 11 to 20 of about 916,375 (359)
Journal of Neurology, Neurosurgery & Psychiatry, 2003 Following the discovery in the early 1960s that mitochondria contain their own DNA (mtDNA), there were two major advances, both in the 1980s: the human mtDNA sequence was published in 1981, and in 1988 the first pathogenic mtDNA mutations were identified. The floodgates were opened, and the 1990s became the decade of the mitochondrial genome. There has
P F, Chinnery, E A, Schon
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Journal of Aging Research, 2011 1Division of Biology of Aging, Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA 2Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, 25008 Lleida, Spain 3Mitochondrial Gerontology and Age-Related Diseases Group, Institute of ...
Leeuwenburgh, Christiaan +2 more
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EMBO reports, 2005 Mitochondria are the main sites of biological energy generation in eukaryotes. These organelles are remnants of a bacterial endosymbiont that took up residence inside a host cell over 1,500 million years ago. Comparative genomics studies suggest that the mitochondrion is monophyletic in origin.
Mark, van der Giezen, Jorge, Tovar
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Antioxidants, 2023 The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneration ...
Nasim Salimiaghdam +8 more
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Mitochondria and Neuroplasticity [PDF]
ASN Neuro, 2010 The production of neurons from neural progenitor cells, the growth of axons and dendrites and the formation and reorganization of synapses are examples of neuroplasticity. These processes are regulated by cell-autonomous and intercellular (paracrine and endocrine) programs that mediate responses of neural cells to environmental input.
Aiwu Cheng, Yan Hou, Mark P Mattson
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Sarcopenia and peripheral arterial disease: a systematic review
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Patients with lower extremity peripheral arterial disease (PAD) and sarcopenia are a population at risk requiring specific and targeted care.
Mégane Pizzimenti +6 more
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Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography [PDF]
, 2017 The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria-junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable
Cabrera-Fuentes, Hector +12 more
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Isolation and analysis of fractions enriched in WrappER-associated mitochondria from mouse liver
STAR Protocols, 2021 Summary: The endoplasmic reticulum (ER) plays a central role in lipid homeostasis, but the role of individual ER subdomains in lipid biology has not been elucidated.
Nicolò Ilacqua +2 more
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Depletion of mitochondria in mammalian cells through enforced mitophagy [PDF]
, 2016 Mitochondria are not only the 'powerhouse' of the cell; they are also involved in a multitude of processes that include calcium storage, the cell cycle and cell death.
Correia-Melo, Clara +3 more
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Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]
, 2016 Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto +9 more
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