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Frontiers in Nutrition, 2023 IntroductionBioactive peptides based on foodstuffs are of particular interest as carriers for calcium delivery due to their safety and high activity. The phosphorylated peptide has been shown to enhance calcium absorption and bone formation.MethodA novel
Xiao Kong +12 more
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A Perspective on Accelerated Aging Caused by the Genetic Deficiency of the Metabolic Protein, OPA1
Frontiers in Neurology, 2021 Autosomal Dominant Optic Atrophy (ADOA) is an ophthalmological condition associated primarily with mutations in the OPA1 gene. It has variable onset, sometimes juvenile, but in other patients, the disease does not manifest until adult middle age despite ...
Irina Erchova +3 more
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Thyroid Research, 2023 Background Subclinical hypothyroidism in pregnancy and definition by upper thyrotropin (TSH) cutoff are controversial. As mitochondria are influenced by thyroid hormones, the purpose in this study was to measure expression of mitochondria-related genes ...
Julie Kristine Guldberg Stryhn +3 more
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Trends in Biochemical Sciences, 2016 Mitochondria are mysterious, marvelous little structures. Despite their long evolutionary history before being co-opted as eukaryotic organelles, these endosymbionts have become entrenched in eukaryotic cell function. Originally thought to be merely the “powerhouse of the cell” (as if that were not enough), interest in these organelles resurged after ...
Allyson Evans, Nicole Neuman
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Antioxidants, 2023 The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneration ...
Nasim Salimiaghdam +8 more
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Genes, 2018 Mitochondrial dysfunction is a central event in many pathologies and contributes as well to age-related processes. However, distinguishing between primary mitochondrial dysfunction driving aging and a secondary mitochondrial impairment resulting from other cell alterations remains challenging.
Theurey, Pierre, Pizzo, Paola
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Sarcopenia and peripheral arterial disease: a systematic review
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Patients with lower extremity peripheral arterial disease (PAD) and sarcopenia are a population at risk requiring specific and targeted care.
Mégane Pizzimenti +6 more
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How mitochondria produce reactive oxygen species
Biochemical Journal, 2008 The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O2•−
M. Murphy
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BioMed Research International, 2013 The future of mitochondrial DNA research has the potential to uncover new insights on genetic diseases and open new opportunities to discover ways to control mitochondria and their influence on the human health and cancer. The outcomes of this work will expand the understanding of cellular respiration and disease risk.
Gurmit Singh +3 more
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Antioxidants, 2022 Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress.
Cindy Barnig +6 more
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