Results 21 to 30 of about 845,219 (308)
Glutathione and mitochondria [PDF]
Frontiers in Pharmacology, 2014 Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of antioxidant and detoxifying enzymes. While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including ...
Ribas, Vicent +2 more
openaire +4 more sources
Antioxidants, 2022 Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress.
Cindy Barnig +6 more
doaj +1 more source
CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
Nature Communications, 2016 β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of ...
Shangcheng Xu +8 more
doaj +1 more source
How proteins are transported into mitochondria [PDF]
, 1981 Most mitochondrial polypeptides are synthesized outside the organelle as precursors which are usually larger than the ‘mature’ polypeptides found within mitochondria.
Neupert, Walter, Schatz, Gottfried
core +1 more source
Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Nature Communications, 2018 Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids,
Dan Shao +11 more
doaj +1 more source
A new limit for blood metabolite analysis using 1H NMR spectroscopy
Journal of Magnetic Resonance Open, 2022 Human blood is the most widely used biospecimen in the clinic and the metabolomics field. While both mass spectrometry and NMR spectroscopy are the two premier analytical platforms in the metabolomics field, NMR exhibits several unsurpassed ...
G.A. Nagana Gowda +2 more
doaj +1 more source
Localization of TCA cycle dehydrogenases in the mitochondria [PDF]
, 1967 The site of localization of TCA cycle dehydrogenases in mitochondria has been investigated by observing the dehydrogenase activities and fine structure of the fractionated samples after freezing and thawing or sonication of beef heart and rat liver ...
Inaba, Kozo +2 more
core +1 more source
Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. [PDF]
, 2015 Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER-mitochondria and ER-vacuole contacts specified by an
Murley, Andrew +5 more
core +2 more sources
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]
, 2017 Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui +15 more
core +1 more source
Sarcopenia and cardiovascular diseases: A systematic review and meta‐analysis
Journal of Cachexia, Sarcopenia and Muscle, 2023 Sarcopenia is an age‐related disease and is often accompanied by other diseases. Now, many studies have shown that cardiovascular diseases (CVDs) may raise the incidence rate of sarcopenia. Therefore, the purpose of this study was to conduct a systematic
Xinrong Zuo +6 more
doaj +1 more source