Semi-Supervised Segmentation of Mitochondria from Electron Microscopy Images Using Spatial Continuity [PDF]
2022 IEEE 19th International Symposium on Biomedical Imaging
(ISBI). IEEE, 2022: 1-5, 2022 Morphology of mitochondria plays critical roles in mediating their physiological functions. Accurate segmentation of mitochondria from 3D electron microscopy (EM) images is essential to quantitative characterization of their morphology at the nanometer scale.
arxiv +1 more source
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Journal of Cell Biology, 2008 Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease.
Derek P. Narendra +3 more
semanticscholar +1 more source
Calcium and mitochondria [PDF]
FEBS Letters, 2004 The literature suggests that the physiological functions for which mitochondria sequester Ca2+ are (1) to stimulate and control the rate of oxidative phosphorylation, (2) to induce the mitochondrial permeability transition (MPT) and perhaps apoptotic cell death, and (3) to modify the shape of cytosolic Ca2+ pulses or transients.
Jason D. Salter +4 more
openaire +3 more sources
CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
Nature Communications, 2016 β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of ...
Shangcheng Xu +8 more
doaj +1 more source
Sarcopenia and cardiovascular diseases: A systematic review and meta‐analysis
Journal of Cachexia, Sarcopenia and Muscle, 2023 Sarcopenia is an age‐related disease and is often accompanied by other diseases. Now, many studies have shown that cardiovascular diseases (CVDs) may raise the incidence rate of sarcopenia. Therefore, the purpose of this study was to conduct a systematic
Xinrong Zuo +6 more
doaj +1 more source
BCL-2 family members and the mitochondria in apoptosis.
Genes & Development, 1999 A variety of physiological death signals, as well as pathological cellular insults, trigger the genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis manifests in two major execution programs downstream of the death signal: the
A. Gross, J. McDonnell, S. Korsmeyer
semanticscholar +1 more source
Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Nature Communications, 2018 Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids,
Dan Shao +11 more
doaj +1 more source
Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances
Molecular Neurodegeneration, 2020 Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain.
Wenzhang Wang +4 more
semanticscholar +1 more source
Preparation and Antioxidant Activities of Phenylethanoids from Dracocephalum heterophyllum
Separations, 2022 The health benefits of Dracocephalum heterophyllum are widely reported in traditional Tibetan medicines, but the reported chemical composition is limited, probably due to difficulties in separating and purifying compounds.
Yue Lv +6 more
doaj +1 more source
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
JCI Insight, 2020 Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for malignancies and is associated with poor prognosis.
T. Tadokoro +11 more
semanticscholar +1 more source