Results 31 to 40 of about 1,007,169 (424)
Glutathione and mitochondria [PDF]
Frontiers in Pharmacology, 2014 Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of antioxidant and detoxifying enzymes. While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including ...
Carmen García-Ruiz +4 more
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The Mitochondrial Genome in Aging and Disease and the Future of Mitochondrial Therapeutics
Biomedicines, 2022 Mitochondria are intracellular organelles that utilize nutrients to generate energy in the form of ATP by oxidative phosphorylation. Mitochondrial DNA (mtDNA) in humans is a 16,569 base pair double-stranded circular DNA that encodes for 13 vital proteins
Sanjana Saravanan +5 more
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Frontiers in Nutrition, 2023 IntroductionBioactive peptides based on foodstuffs are of particular interest as carriers for calcium delivery due to their safety and high activity. The phosphorylated peptide has been shown to enhance calcium absorption and bone formation.MethodA novel
Xiao Kong +12 more
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A Perspective on Accelerated Aging Caused by the Genetic Deficiency of the Metabolic Protein, OPA1
Frontiers in Neurology, 2021 Autosomal Dominant Optic Atrophy (ADOA) is an ophthalmological condition associated primarily with mutations in the OPA1 gene. It has variable onset, sometimes juvenile, but in other patients, the disease does not manifest until adult middle age despite ...
Irina Erchova +3 more
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Mitochondria and Neuroplasticity [PDF]
ASN Neuro, 2010 The production of neurons from neural progenitor cells, the growth of axons and dendrites and the formation and reorganization of synapses are examples of neuroplasticity. These processes are regulated by cell-autonomous and intercellular (paracrine and endocrine) programs that mediate responses of neural cells to environmental input.
Mark P. Mattson +3 more
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Thyroid Research, 2023 Background Subclinical hypothyroidism in pregnancy and definition by upper thyrotropin (TSH) cutoff are controversial. As mitochondria are influenced by thyroid hormones, the purpose in this study was to measure expression of mitochondria-related genes ...
Julie Kristine Guldberg Stryhn +3 more
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Trends in Biochemical Sciences, 2016 Mitochondria are mysterious, marvelous little structures. Despite their long evolutionary history before being co-opted as eukaryotic organelles, these endosymbionts have become entrenched in eukaryotic cell function. Originally thought to be merely the “powerhouse of the cell” (as if that were not enough), interest in these organelles resurged after ...
Allyson Evans, Nicole Neuman
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Antioxidants, 2023 The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneration ...
Nasim Salimiaghdam +8 more
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Genes, 2018 Mitochondrial dysfunction is a central event in many pathologies and contributes as well to age-related processes. However, distinguishing between primary mitochondrial dysfunction driving aging and a secondary mitochondrial impairment resulting from other cell alterations remains challenging.
Theurey, Pierre, Pizzo, Paola
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Sarcopenia and peripheral arterial disease: a systematic review
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Patients with lower extremity peripheral arterial disease (PAD) and sarcopenia are a population at risk requiring specific and targeted care.
Mégane Pizzimenti +6 more
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