Results 61 to 70 of about 1,007,169 (424)
Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. [PDF]
, 2015 Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER-mitochondria and ER-vacuole contacts specified by an
Murley, Andrew +5 more
core +2 more sources
Heat release by isolated mouse brain mitochondria detected with diamond thermometer [PDF]
arXiv, 2022 A production of heat by mitochondria is critical for maintaining body temperature, regulating metabolic rate and preventing oxidative damage to mitochondria and cells. Up to now mitochondrion heat production was characterized only by methods based on fluorescent probes which are sensitive to environmental variations (viscosity, pH, ionic strength ...
arxiv
The role of cytochrome c in caspase activation in Drosophila melanogaster cells [PDF]
, 2002 The release of cytochrome c from mitochondria is necessary for the formation of the Apaf-1 apoptosome and subsequent activation of caspase-9 in mammalian cells.
Cakouros, Dimitrios +5 more
core +3 more sources
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin [PDF]
, 2010 Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy;
A. J. Whitworth +28 more
core +2 more sources
Living unicellular eukaryote Tetrahymena pyriformis as a model for study [PDF]
, 2011 Some animals are able to survive for a long time under conditions of drastically reduced oxidative metabolism, called metabolic depression. The most investigated type of metabolic depression is hibernation.
Elena Mokhova, Elena Mokhova
core +3 more sources
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
PLoS Biology, 2010 Mutations in PINK1 or Parkin lead to familial parkinsonism. The authors suggest that PINK1 and Parkin form a pathway that senses damaged mitochondria and selectively targets them for degradation.
Derek P. Narendra +7 more
semanticscholar +1 more source
STAMPing into Mitochondria [PDF]
International Journal of Biological Sciences, 2014 Six transmembrane protein of prostate 2 (STAMP2) is a protein that has been extensively studied due to its association with prostate cancer. Currently, STAMP2 is well known for its critical role in metabolism and modulating inflammatory signals. Even so, the molecular mechanism of STAMP2 activity and its downstream effectors are still largely unknown ...
Yoo, SK Yoo, Seong Keun +2 more
openaire +4 more sources
Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes
Stem Cells International, 2017 Human pluripotent stem cells derived cardiomyocytes (PSC-CMs) have been widely used for disease modeling, drug safety screening, and preclinical cell therapy to regenerate myocardium.
Dao-Fu Dai +4 more
doaj +1 more source
Frontiers in Nutrition, 2022 Obesity is a significant health concern as a result of poor-quality diet, for example, high-fat diet (HFD). Although multiple biological and molecular changes have been identified to contribute to HFD-induced pain susceptibility, the mechanisms are not ...
Nan Lian +14 more
doaj +1 more source
Transport of Proteins into Mitochondria [PDF]
, 1980 The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner.
Allen E. H. +41 more
core +1 more source