Results 1 to 10 of about 186,810 (278)

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries [PDF]

mBio, 2016
Infection with human cytomegalovirus (HCMV) profoundly affects cellular metabolism. Like in tumor cells, HCMV infection increases glycolysis, and glucose carbon is shifted from the mitochondrial tricarboxylic acid cycle to the biosynthesis of fatty acids.
S. Karniely, M. P. Weekes, R. Antrobus, J. Rorbach, L. van Haute, Y. Umrania, D. L. Smith, R. J. Stanton, M. Minczuk, P. J. Lehner, J. H. Sinclair   +10 more
doaj   +5 more sources

Regulation of Mitochondrial Biogenesis in Diabetic Retinopathy [PDF]

Cells
Mitochondrial dysfunction plays a major role in diabetic retinopathy development and in its resistance to halt after the reversal of hyperglycemia (metabolic memory).
Jay Kumar, Renu A. Kowluru
doaj   +2 more sources

Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1α in Granulosa Cells [PDF]

Research
Follicle-stimulating hormone (FSH) coordinates ovarian follicle development by aligning mitochondrial biogenesis with increased metabolic demand. Although FSH is known to stimulate glycolysis in granulosa cells (GCs), the mechanism by which glycolytic ...
Gang Wu, Min Chen, Chengyu Li, Mengli Wei, Yitong Pan, Tong He, Zhaojun Liu, Hongmin Li, Chunlei Zhang, Jia-Qing Zhang, Yanan Sheng, Yang Liu, Honglin Liu, Ming Shen   +13 more
doaj   +2 more sources

A transcription network underlies the dual genomic coordination of mitochondrial biogenesis [PDF]

eLife
Mitochondrial biogenesis requires the expression of genes encoded by both the nuclear and mitochondrial genomes. However, aside from a handful transcription factors regulating specific subsets of mitochondrial genes, the overall architecture of the ...
Fan Zhang, Annie Lee, Anna V Freitas, Jake T Herb, Zong-Heng Wang, Snigdha Gupta, Zhe Chen, Hong Xu   +7 more
doaj   +2 more sources

DNM1L-mediated fission governs mitophagy & mitochondrial biogenesis during myogenic differentiation [PDF]

Cell Communication and Signaling
Background Remodeling of the mitochondrial network is implicated in myogenesis. Remodeling processes including mitochondrial fission, mitophagy, and biogenesis are important as they finetune the mitochondrial network to meet the increased energetic ...
Fasih A. Rahman, Jasmine M. Friedrich Yap, Tyler M. Joseph, Amanda M. Adam, Sarah M. Chapman, Joe Quadrilatero   +5 more
doaj   +2 more sources

Tom70-based transcriptional regulation of mitochondrial biogenesis and aging

eLife, 2022
Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu, Catherine E Chang, Alexandra C Wooldredge, Benjamin Fong, Brian K Kennedy, Chuankai Zhou   +5 more
doaj   +1 more source

Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation

Cell Communication and Signaling, 2023
Background Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth.
Bowen Hu, Changbin Zhao, Xiangchun Pan, Haohui Wei, Guodong Mo, Mingjian Xian, Wen Luo, Qinghua Nie, Hongmei Li, Xiquan Zhang   +9 more
doaj   +1 more source

Resveratrol Improves Mitochondrial Biogenesis Function and Activates PGC-1α Pathway in a Preclinical Model of Early Brain Injury Following Subarachnoid Hemorrhage

Frontiers in Molecular Biosciences, 2021
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) has been shown to play a pivotal role in the regulation of mitochondrial biogenesis in diseases.
Jian Zhou, Zaijia Yang, Ruiming Shen, Wangwang Zhong, Huiduan Zheng, Zhenggang Chen, Jianjian Tang, Juan Zhu   +7 more
doaj   +1 more source

Reperfusion promotes mitochondrial biogenesis following focal cerebral ischemia in rats. [PDF]

PLoS ONE, 2014
BACKGROUND AND PURPOSE: Reperfusion after transient cerebral ischemia causes severe damage to mitochondria; however, little is known regarding the continuous change in mitochondrial biogenesis during reperfusion.
Yuying Xie, Jun Li, Guibo Fan, Sihua Qi, Bing Li   +4 more
doaj   +1 more source

Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. [PDF]

PLoS ONE, 2008
DNA damage such as double-stranded DNA breaks (DSBs) has been reported to stimulate mitochondrial biogenesis. However, the underlying mechanism is poorly understood. The major player in response to DSBs is ATM (ataxia telangiectasia mutated).
Xuan Fu, Shan Wan, Yi Lisa Lyu, Leroy F Liu, Haiyan Qi   +4 more
doaj   +1 more source