Results 11 to 20 of about 712,444 (333)

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Journal of Biomedical Sciences, 2023
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues.
Lei Liu, Yanjun Li, Guo Chen, Quan Chen
semanticscholar   +1 more source

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

Science, 2023
Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate–activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effects ...
Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, S. Weiser Novak, Jingting Yu, Rebecca Gilson, Kristina Hellberg, Lingjing Fang, Arlo Sheridan, N. Hah, G. Shadel, U. Manor, R. Shaw   +14 more
semanticscholar   +1 more source

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Science Advances, 2023
Nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice.
H. Lapatto, Minna Kuusela, A. Heikkinen, M. Muniandy, B. W. van der Kolk, Swetha Gopalakrishnan, Noora Pöllänen, M. Sandvik, Mark S. Schmidt, S. Heinonen, Sina Saari, Juho Kuula, A. Hakkarainen, Janne Tampio, T. Saarinen, M. Taskinen, N. Lundbom, P. Groop, M. Tiirola, P. Katajisto, M. Lehtonen, C. Brenner, J. Kaprio, S. Pekkala, M. Ollikainen, K. Pietiläinen, E. Pirinen   +26 more
semanticscholar   +1 more source

Tom70-based transcriptional regulation of mitochondrial biogenesis and aging

eLife, 2022
Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu, Catherine E Chang, Alexandra C Wooldredge, Benjamin Fong, Brian K Kennedy, Chuankai Zhou   +5 more
doaj   +1 more source

Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease

Advancement of science, 2023
Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD.
Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, Zhen Li   +7 more
semanticscholar   +1 more source

Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis

Nature Communications, 2023
The use of exogenous mitochondria to replenish damaged mitochondria has been proposed as a strategy for the treatment of pulmonary fibrosis. However, the success of this strategy is partially restricted by the difficulty of supplying sufficient ...
Ting Huang, Ruyi Lin, Yu Su, Haobo Sun, Xixi Zheng, Jinsong Zhang, Xiaoyan Lu, Baiqin Zhao, Xinchi Jiang, Lingling Huang, Ni Li, Jing Shi, Xiaohui Fan, Donghang Xu, Tianyuan Zhang, Jianqing Gao   +15 more
semanticscholar   +1 more source

Dual roles of mTOR in skeletal muscle adaptation: coordinating hypertrophic and mitochondrial biogenesis pathways for exercise-induced chronic disease management. [PDF]

Front Med (Lausanne)
Zhao YC.
europepmc   +3 more sources

Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation

Cell Communication and Signaling, 2023
Background Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth.
Bowen Hu, Changbin Zhao, Xiangchun Pan, Haohui Wei, Guodong Mo, Mingjian Xian, Wen Luo, Qinghua Nie, Hongmei Li, Xiquan Zhang   +9 more
doaj   +1 more source

NRF1‐mediated mitochondrial biogenesis antagonizes innate antiviral immunity

EMBO Journal, 2023
Mitochondrial biogenesis is the process of generating new mitochondria to maintain cellular homeostasis. Here, we report that viruses exploit mitochondrial biogenesis to antagonize innate antiviral immunity.
Tian Zhao, Jiaojiao Zhang, Hong-ling Lei, Yuanyuan Meng, Hongcheng Cheng, Yanping Zhao, Guangfeng Geng, Chenglong Mu, Linbo Chen, Qiangqiang Liu, Qian Luo, Chuanmei Zhang, Yijia Long, J. Su, Yinhao Wang, Zhuoya Li, Jiaxing Sun, Guo Chen, Yanjun Li, Xudong Liao, Y. Shang, Gang Hu, Quan Chen, Yushan Zhu   +23 more
semanticscholar   +1 more source

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PINK1-deficient Human Dopamine Neurons

bioRxiv, 2023
Mutations and loss of activity in the protein kinase PINK1 play a role in the pathogenesis of Parkinson’s disease (PD). PINK1 regulates many aspects of mitochondrial quality control including mitochondrial autophagy (mitophagy), fission, fusion ...
Hu Wang, Rong Chen, Liming Xiao, Manoj Kumar, Jesús Acevedo-Cintrón, J. Siuda, D. Koziorowski, Z. Wszolek, V. Dawson, T. Dawson   +9 more
semanticscholar   +1 more source