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Mitochondrial biogenesis in exercise and in ageing☆
Advanced Drug Delivery Reviews, 2009Mitochondrial biogenesis is critical for the normal function of cells. It is well known that mitochondria are produced and eventually after normal functioning they are degraded. Thus, the actual level of mitochondria in cells is dependent both on the synthesis and the degradation.
Jose, Viña +6 more
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Translational regulation of mitochondrial biogenesis
Biochemical Society Transactions, 2016Mitochondria are generated by the expression of genes on both nuclear and mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to cellular energy demand, developmental signals and environmental stimuli. Mechanistic target of rapamycin (mTOR) pathway regulates mitochondrial biogenesis to co-ordinate energy homeostasis with cell ...
Yi, Zhang, Hong, Xu
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2003
Abstract The chapter focuses on the intensively studied area of protein import into mitochondria and protein maturation within mitochondria. Existing knowledge relies heavily on work done in yeast; recent identification of diseases that result when these processes are disrupted is providing valuable insights into human mitochondrial ...
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Abstract The chapter focuses on the intensively studied area of protein import into mitochondria and protein maturation within mitochondria. Existing knowledge relies heavily on work done in yeast; recent identification of diseases that result when these processes are disrupted is providing valuable insights into human mitochondrial ...
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Mitochondrial Biogenesis in Striated Muscle
Canadian Journal of Applied Physiology, 1994Mitochondrial biogenesis (synthesis) has been observed to occur in skeletal muscle in response to chronic use. It also occurs in cardiac muscle during growth and hypertrophy, and it may be impaired during the aging process. This review summarizes the literature on the processes of mitochondrial biogenesis at the biochemical and molecular levels, with ...
D A, Hood +6 more
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Evolution of mitochondrial protein biogenesis
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009Mitochondria and the nucleus are key features that distinguish eukaryotic cells from prokaryotic cells. Mitochondria originated from a bacterium that was endosymbiotically taken up by another cell more than a billion years ago. Subsequently, most mitochondrial genes were transferred and integrated into the host cell's genome, making the evolution of ...
Kutik, Stephan +3 more
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Isoflavones Promote Mitochondrial Biogenesis
The Journal of Pharmacology and Experimental Therapeutics, 2008Mitochondrial damage is often both the cause and outcome of cell injury resulting from a variety of toxic insults, hypoxia, or trauma. Increasing mitochondrial biogenesis after renal proximal tubular cell (RPTC) injury accelerated the recovery of mitochondrial and cellular functions (Biochem Biophys Res Commun 355:734-739, 2007).
Kyle A, Rasbach, Rick G, Schnellmann
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Biogenesis of the mitochondrial TOM complex
Trends in Biochemical Sciences, 2002The translocase at the outer membrane of mitochondria (TOM complex) mediates the initial steps of the import of preproteins into the organelle, which are essential for mitochondrial biogenesis and, therefore, for eukaryotic cell viability. The TOM complex is a multisubunit molecular machine with a dynamic structure.
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Mitochondrial biogenesis: pharmacological approaches.
Current pharmaceutical design, 2015Yes
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Mitochondrial Biogenesis in Neurons: How and Where
International Journal of Molecular Sciences, 2021CARLOS Cardanho-Ramos, Vanessa A Morais
exaly
Mitochondrial Biogenesis in Skeletal Muscle
Mitochondrial biogenesis refers to the synthesis of nuclear- and mitochondrially encoded proteins, along with phospholipids, that aid in the expansion of the mitochondrial network. In skeletal muscle, mitochondria are organized as a reticulum, as this ideal morphology complements the elongated shape of a myofibre.David A, Hood +4 more
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