Results 261 to 270 of about 187,742 (299)
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2003
Abstract The chapter focuses on the intensively studied area of protein import into mitochondria and protein maturation within mitochondria. Existing knowledge relies heavily on work done in yeast; recent identification of diseases that result when these processes are disrupted is providing valuable insights into human mitochondrial ...
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Abstract The chapter focuses on the intensively studied area of protein import into mitochondria and protein maturation within mitochondria. Existing knowledge relies heavily on work done in yeast; recent identification of diseases that result when these processes are disrupted is providing valuable insights into human mitochondrial ...
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Biogenesis of Mitochondrial Proteins
2012Depending on the organism, mitochondria consist approximately of 500-1,400 different proteins. By far most of these proteins are encoded by nuclear genes and synthesized on cytosolic ribosomes. Targeting signals direct these proteins into mitochondria and there to their respective subcompartment: the outer membrane, the intermembrane space (IMS), the ...
Johannes M, Herrmann +3 more
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Translational regulation of mitochondrial biogenesis
Biochemical Society Transactions, 2016Mitochondria are generated by the expression of genes on both nuclear and mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to cellular energy demand, developmental signals and environmental stimuli. Mechanistic target of rapamycin (mTOR) pathway regulates mitochondrial biogenesis to co-ordinate energy homeostasis with cell ...
Yi, Zhang, Hong, Xu
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Biogenesis of mitochondrial membrane proteins
Current Opinion in Cell Biology, 2009Mitochondria are ubiquitous, double-membrane bound organelles, which have developed from endosymbiotic alpha-proteobacteria during evolution. Outer and inner membranes of mitochondria are equipped with characteristic sets of membrane proteins required for energy conversion, metabolite and protein transport, membrane fusion and fission, and signal ...
Becker, Thomas +3 more
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Mitochondrial Biogenesis in Striated Muscle
Canadian Journal of Applied Physiology, 1994Mitochondrial biogenesis (synthesis) has been observed to occur in skeletal muscle in response to chronic use. It also occurs in cardiac muscle during growth and hypertrophy, and it may be impaired during the aging process. This review summarizes the literature on the processes of mitochondrial biogenesis at the biochemical and molecular levels, with ...
D A, Hood +6 more
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Mitochondrial biogenesis during cellular differentiation
American Journal of Physiology-Cell Physiology, 1997Mitochondrial biogenesis was studied during differentiation of two immortalized cell lines (C2C12, 3T3) with enzyme measurements, Northern blots, and quantitative ultrastructure. Citrate synthase, isocitrate dehydrogenase, and 3-hydroxyacyl-CoA dehydrogenase (nuclear encoded, mitochondrial matrix location) showed linear, four- to sixfold increases in ...
C D, Moyes +4 more
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Mitochondrial biogenesis in cardiac pathophysiology
Pharmacological Reports, 2009Cardiac performance depends on a fine balance between the work the heart has to perform to satisfy the needs of the body and the energy that it is able to produce. Thus, energy production by oxidative metabolism, the main energy source of the cardiac muscle, has to be strictly regulated to adapt to cardiac work.
Stéphanie, Rimbaud +2 more
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Evolution of mitochondrial protein biogenesis
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009Mitochondria and the nucleus are key features that distinguish eukaryotic cells from prokaryotic cells. Mitochondria originated from a bacterium that was endosymbiotically taken up by another cell more than a billion years ago. Subsequently, most mitochondrial genes were transferred and integrated into the host cell's genome, making the evolution of ...
Kutik, Stephan +3 more
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Mitochondrial biogenesis: Inhibitors of mitochondrial protein synthesis
Molecular and Cellular Biochemistry, 1977The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and ...
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