Results 111 to 120 of about 613,759 (317)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

RETRACTED: MtDNA polymorphism analyses in the Chinese Mongolian group: Efficiency evaluation and further matrilineal genetic structure exploration

Molecular Genetics & Genomic Medicine, 2019
Background Profiling of mitochondrial DNA is surely to provide valuable investigative clues for forensic cases involving highly degraded specimens or complex maternal lineage kinship determination.
Qiong Lan, Tong Xie, Xiaoye Jin, Yating Fang, Shuyan Mei, Guang Yang, Bofeng Zhu   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The role of mitochondrial DNA in tumorigenesis [PDF]

Mitochondria are cytoplasmic organelles that are found in almost all mammalian cells. Mitochondria contain their own genome, mitochondrial DNA (mtDNA) that encodes 13 subunits of the electron transfer chain, which is the primary generator of cellular ...
Dickinson, Adam
core  

The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates

, 2011
In most species mitochondrial DNA (mtDNA) is inherited maternally in an apparently clonal fashion, although how this is achieved remains uncertain.
Wolff, Jonci N., Daniel J White, Michael Woodhams, Neil J. Gemmell, Gemmell, Neil J., White Daniel J., Daniel J. White, Woodhams, Michael, White, Helen E., White, Helen, White, Daniel, Wolff Jonci N., Woodhams Michael, Gemmell Neil J., Neil J Gemmell, Helen E White, White, Daniel J., Wolff, Jonci, Jonci N. Wolff, Jonci N Wolff, Gemmell, Neil, Helen E. White, White Helen E.   +22 more
core   +1 more source

Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases

Genes and Diseases
Neuronal death is associated with mitochondrial dysfunction caused by mutations in mitochondrial DNA. Mitochondrial DNA becomes damaged when processes such as replication, repair, and nucleotide synthesis are compromised.
Ye Hong, Ying Song, Wenjun Wang, Jinghui Shi, Xi Chen   +4 more
doaj   +1 more source

Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease

Neurobiology of Disease, 2016
Mitochondrial DNA regulates mitochondrial function which is altered in both idiopathic and familial forms of Parkinson's disease. To investigate whether these two disease forms exhibit an altered regulation of mitochondrial DNA we measured cell free ...
Petar Podlesniy, Dolores Vilas, Peggy Taylor, Leslie M. Shaw, Eduard Tolosa, Ramon Trullas   +5 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Mitochondrial DNA and Genetic Disease [PDF]

Developmental Medicine & Child Neurology, 1988
AbstractSince the human mitochondrial genome was characterised and sequenced in 1981(1), it has been viewed as the likely site of genetic diseases showing a maternal inheritance pattern and associated with defects of the respiratory chain, such as the mitochondrial myopathies (MMs)†(2).
openaire   +4 more sources

Cell-free mitochondrial DNA copy number variation in head and neck squamous cell carcinoma: A study of non-invasive biomarker from Northeast India

Tumor Biology, 2017
Head and neck squamous cell carcinoma is the most commonly diagnosed cancer worldwide. The lifestyle, food habits, and customary practices manifest the Northeast Indian population toward higher susceptibility to develop head and neck squamous cell ...
Manish Kumar, Shilpee Srivastava, Seram Anil Singh, Anup Kumar Das, Ganesh Chandra Das, Bishal Dhar, Sankar Kumar Ghosh, Rosy Mondal   +7 more
doaj   +1 more source