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The regulation of mitochondrial dynamics
Current Opinion in Cell Biology, 2014The structure of mitochondria is highly dynamic. Mitochondrial shape is cell-type specific and can be modified to meet changing requirements in energy production, calcium homeostasis, lipid biogenesis, fatty acid synthesis and other mitochondrial activities.
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Mitochondrial Dynamics in Mammals
2004This chapter discusses the role of mitochondria dynamics in mammalian mitochondrial morphology, mitochondrial function, disease, embryogenesis, and apoptosis. It defines mitochondria as static, kidney bean-shaped organelles that have the mundane chore of providing energy for the cell.
Chen, Hsiuchen, Chan, David C.
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The influence of mitochondrial dynamics on mitochondrial genome stability
Current Genetics, 2017Mitochondria are dynamic organelles that fuse and divide. These changes alter the number and distribution of mitochondrial structures throughout the cell in response to developmental and metabolic cues. We have demonstrated that mitochondrial fission is essential to the maintenance of mitochondrial DNA (mtDNA) under changing metabolic conditions in ...
Christopher T, Prevost +6 more
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Mitochondrial dynamics and inter-mitochondrial communication in the heart
Archives of Biochemistry and Biophysics, 2019Mitochondria are organelles highly dynamic in most types of cells, constantly changing morphology and forming dynamically continuous networks. Defects of mitochondrial dynamics are associated with various human diseases including neurodegenerative diseases and cardiovascular diseases.
Yang-Po, Cao, Ming, Zheng
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Mitochondrial Dynamics in Disease
New England Journal of Medicine, 2007Mitochondria are subcellular organelles that coordinate numerous metabolic reactions, including those of the respiratory complexes that produce the ATP that powers cellular reactions. They have often been depicted as static, with a kidney-bean shape, but there is a growing appreciation of their dynamic nature.
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Mitochondrial dynamics in filamentous fungi
Fungal Genetics and Biology, 2002Mitochondria are essential organelles of eukaryotic cells. They grow continuously throughout the cell cycle and are inherited by daughter cells upon cell division. Inheritance of mitochondria and maintenance of mitochondrial distribution and morphology require active transport of the organelles along the cytoskeleton and depend on membrane fission and ...
Benedikt, Westermann, Holger, Prokisch
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Mitochondrial morphology is dynamic and varied
Molecular and Cellular Biochemistry, 2004The morphology of mitochondria is dynamic, often changing within a cell and from one cell type to the next. In the past few years, significant advances have been made in the study of mechanisms that help determine the morphologies of mitochondria and their intracellular distributions.
Daniel A, Rube +1 more
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Structural implications of mitochondrial dynamics
Biotechnology Journal, 2008AbstractMitochondrial components are continuously distributed throughout the whole chondriome of a cell by fusion and fission. Thus, a single mitochondrion represents a transient fraction of the chondriome. Mitochondrial dynamics are responsible for intracellular distribution and reaction of mitochondria to functional requirements.
Jürgen, Bereiter-Hahn +3 more
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Mitochondrial Dynamics and Peripheral Neuropathy
The Neuroscientist, 2007Peripheral neuropathy is perhaps the archetypal disease of axonal degeneration, characteristically involving degeneration of the longest axons in the body. Evidence from both inherited and acquired forms of peripheral neuropathy strongly supports that the primary pathology is in the axons themselves and points to disruption of axonal transport as an ...
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Structural dynamics of the mitochondrial compartment
Mutation Research/DNAging, 1992The metabolic activities of mitochondria have been extensively characterized. However, there is much less known about the morphogenic changes of the mitochondrial compartment during growth, development and aging of the cell and the consequences of those structural changes on cellular metabolism.
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