Results 251 to 260 of about 341,168 (306)

HIF-1α suppresses SNPH expression to facilitate liver metastasis of colorectal cancer through regulating mitochondrial dynamics and filopodia formation. [PDF]

Cell Death Dis
Zhan L, Li X, Li X, Fei Q, Jin Y, Yu J, Tian L, Li F, Li C, Dong Q, Zhang Y, Sun S, Zhang J.   +12 more
europepmc   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Integrative Machine Learning and Experimental Validation Identify FIS1 as a Candidate Biomarker Linked to Mitochondrial Dynamics in Pulmonary Hypertension. [PDF]

Cells
Zhang Y, Dai Q, Gong L, Zheng R, Huang W, Wang F, Yuan R, Song L, Dai A.   +8 more
europepmc   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Anandamide-Induced Neuroprotection of Cortical Neurons Relies on Metabolic/Redox Regulation and Mitochondrial Dynamics. [PDF]

Mol Neurobiol
Torres-Román AL, Gavaldà-Vives T, Simón-Sánchez S, Aparicio-Trejo OE, Pedraza-Chaverri J, López-Goerne T, Gómez AO, Tinkov AA, Aschner M, Galve-Roperh I, Santamaría A.   +10 more
europepmc   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

AP39 alleviates HHCY-induced myocardial remodeling by regulating FUNDC1-mediated mitochondrial dynamics via S-sulfhydration of NEDD8/CUL4B. [PDF]

Front Pharmacol
Li Y, Jiang J, Song Y, Yang T, Yuan X, Li X, Luo C, Shi Y, Liu S, Chu C, Yang J.   +10 more
europepmc   +1 more source

PGAM5 cleavage and oligomerization equilibrates mitochondrial dynamics under stress by regulating DRP1 function. [PDF]

J Cell Sci
Nag S, Szederkenyi K, Yip CM, McQuibban GA.   +3 more
europepmc   +1 more source

Targeting MFF succinylation: a novel therapeutic strategy for premature ovarian insufficiency by restoring mitochondrial dynamics in granulosa cells. [PDF]

J Ovarian Res
Cao Y, Tong X, Hu W, Wang Y, Lu W, Chen Y, You J, Feng Y, Song Q.   +8 more
europepmc   +1 more source