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Mitochondrial Dynamics and Peripheral Neuropathy
The Neuroscientist, 2007Peripheral neuropathy is perhaps the archetypal disease of axonal degeneration, characteristically involving degeneration of the longest axons in the body. Evidence from both inherited and acquired forms of peripheral neuropathy strongly supports that the primary pathology is in the axons themselves and points to disruption of axonal transport as an ...
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Mitochondrial Dynamics in Peripheral Neuropathies
Antioxidants & Redox Signaling, 2014Mitochondrial dynamics describes the continuous change in the position, size, and shape of mitochondria within cells. The morphological and functional complexity of neurons, the remarkable length of their processes, and the rapid changes in metabolic requirements arising from their intrinsic excitability render these cells particularly dependent on ...
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The regulation of mitochondrial dynamics
Current Opinion in Cell Biology, 2014The structure of mitochondria is highly dynamic. Mitochondrial shape is cell-type specific and can be modified to meet changing requirements in energy production, calcium homeostasis, lipid biogenesis, fatty acid synthesis and other mitochondrial activities.
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Molecular mechanisms of mitochondrial dynamics
Nature Reviews Molecular Cell BiologyMitochondria not only synthesize energy required for cellular functions but are also involved in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation and immunity. Mitochondria are dynamic organelles that undergo cycles of fission and fusion, and these transitions between fragmented and hyperfused networks ensure ...
Luis-Carlos Tábara +2 more
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Regulation of microtubule dynamics, mechanics and function through the growing tip
Nature Reviews Molecular Cell Biology, 2021Nikita B Gudimchuk, J Richard Mcintosh
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Biochemical and mechanical regulation of actin dynamics
Nature Reviews Molecular Cell Biology, 2022Pekka Lappalainen, Tommi Kotila
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The cell biology of mitochondrial membrane dynamics
Nature Reviews Molecular Cell Biology, 2020Marta Giacomello +2 more
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