Results 71 to 80 of about 337,835 (308)

Hybridization and extensive mitochondrial introgression among fire salamanders in peninsular Italy [PDF]

, 2018
Discordance between mitochondrial and nuclear patterns of population genetic structure is providing key insights into the eco-evolutionary dynamics between and within species, and their assessment is highly relevant to biodiversity monitoring practices ...
Arduino, Paola, Bisconti, Roberta, Canestrelli, Daniele, Nascetti, Giuseppe, Porretta, Daniele   +4 more
core   +2 more sources

Mitochondrial dynamics and cancer

Seminars in Cancer Biology, 2009
Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics.
Grandemange, Stéphanie, Herzig, Sébastien, Martinou, Jean-Claude   +2 more
openaire   +5 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells

Veterinary Sciences
Background: Mitochondria are highly dynamic organelles that undergo fusion/fission dynamics, and emerging evidence has established that mitochondrial dynamics plays a crucial regulatory role in the process of viral infection.
Xiuhan Xu, Yuan Zhao, Zhenbang Zhu, Wei Wen, Xiangdong Li   +4 more
doaj   +1 more source

Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults

Physiological Reports, 2020
We investigated the acute and chronic effects of resistance training (RT) on skeletal muscle markers of mitochondrial content and remodeling in older, untrained adults.
Paulo H.C. Mesquita, Donald A. Lamb, Hailey A. Parry, Johnathon H. Moore, Morgan A. Smith, Christopher G. Vann, Shelby C. Osburn, Carlton D. Fox, Bradley A. Ruple, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts   +13 more
doaj   +1 more source

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. [PDF]

, 2017
Intestinal stem cells (ISCs) maintain the midgut epithelium in Drosophila melanogaster Proper cellular turnover and tissue function rely on tightly regulated rates of ISC division and appropriate differentiation of daughter cells.
Abramov, Amcheslavsky, Amcheslavsky, Amcheslavsky, Benard, Biteau, Biteau, Biteau, Buchon, Buchon, Buchon, Christopher L. Koehler, Clark, Clarkson, Coppé, Correia-Melo, D. Leanne Jones, Deng, Greene, Guo, Guy A. Perkins, Hackenbrock, Han, Henchcliffe, Hochmuth, Hur, Jiang, Jiang, Jones, Kashatus, Lee, Lee, Li, Liu, Maeda, Marianes, Mark H. Ellisman, McGuire, Micchelli, Myant, Nakamura, Nicholson, Ohlstein, Ohlstein, Osterwalder, O’Brien, Park, Passos, Poole, Poole, Rana, Rera, Resende, Resnik-Docampo, Roman, Springer, Sykiotis, Takashima, Tian, Twig, Wang, Wang, Wei, Westermann, Yang, Youle, Zeng, Zeng, Zhu   +68 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Excess Branched-Chain Amino Acids Suppress Mitochondrial Function and Biogenic Signaling but Not Mitochondrial Dynamics in a Myotube Model of Skeletal Muscle Insulin Resistance

Metabolites
Branched-chain amino acids (BCAA) are correlated with severity of insulin resistance, which may partially result from mitochondrial dysfunction. Mitochondrial dysfunction is also common during insulin resistance and is regulated in part by altered ...
Lindsey R. VanDerStad, Emily C. Wyatt, Roger A. Vaughan   +2 more
doaj   +1 more source

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria [PDF]

, 2005
The mitochondrial division machinery regulates mitochondrial dynamics and consists of Fis1p, Mdv1p, and Dnm1p. Mitochondrial division relies on the recruitment of the dynamin-related protein Dnm1p to mitochondria.
Chan, David C., Graumann, Johannes, Griffin, Erik E.   +2 more
core   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source