Results 1 to 10 of about 1,859,766 (381)

Mitochondrial dysfunction in cell senescence and aging

The Journal of Clinical Investigation, 2022
Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane ...
Satomi Miwa, Sonu Kashyap, Eduardo Chini, Thomas von Zglinicki   +3 more
doaj   +2 more sources

Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease

Advanced Science, 2023
Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD.
Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, Zhen Li   +7 more
doaj   +2 more sources

Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells

International Journal of Oral Science, 2021
Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive.
Tong Xu, Qin Dong, Yuxiao Luo, Yanqing Liu, Liang Gao, Yaping Pan, Dongmei Zhang   +6 more
doaj   +2 more sources

Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation [PDF]

Redox Biology, 2019
Inflammation is a major cause of morbidity and mortality in Western societies. Despite use of multiple drugs, both chronic and acute inflammation still represent major health burdens.
Vladimir Mayorov, Peter Uchakin, Venkataraman Amarnath, Alexander V. Panov, Christy C. Bridges, Roman Uzhachenko, Bill Zackert, Christy S. Moore, Sean Davies, Anna Dikalova, Sergey Dikalov   +10 more
doaj   +3 more sources

Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response

Redox Biology, 2022
Genetic mitochondrial dysfunction is frequently associated with various embryonic developmental defects. However, how mitochondria contribute to early development and cell fate determination is poorly studied, especially in humans.
Yan Qi, Yida Ye, Ruxiang Wang, Senlin Yu, Yue Zhang, Jing Lv, Wenwen Jin, Shutao Xia, Wei Jiang, Yifei Li, Donghui Zhang   +10 more
doaj   +1 more source

Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Molecular Neurodegeneration, 2023
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have
Martin T. Henrich, W. Oertel, D. Surmeier, Fanni F. Geibl   +3 more
semanticscholar   +1 more source

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Journal of Translational Medicine, 2023
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes.
Xin Chen, Yi Ji, Ruiqi Liu, Xucheng Zhu, Kexin Wang, Xiaoming Yang, Boya Liu, Zihui Gao, Yan Huang, Yuntian Shen, Hua Liu, Hualin Sun   +11 more
semanticscholar   +1 more source

Mitochondrial Dysfunction in Rheumatoid Arthritis

Biomolecules, 2022
Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction
Chen Ma, Jie Wang, Fenfang Hong, Shulong Yang   +3 more
doaj   +1 more source

Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease

Biomolecules, 2022
Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction observed in preclinical models of DKD as well as in clinical DKD with a ...
Marie Ito, Margaret Zvido Gurumani, Sandra Merscher, Alessia Fornoni   +3 more
doaj   +1 more source

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]

PLoS Genetics, 2018
Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan, Lucy Granat, Ramya Ranganathan, Vandana K Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G Ballard, Joseph M Bateman   +8 more
doaj   +1 more source