Results 111 to 120 of about 1,226,681 (303)

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart [PDF]

, 2014
Hypoxic exposure is associated with impaired cardiac energetics in humans and altered mitochondrial function, with suppressed complex I-supported respiration, in rat heart.
Fernandez, BO, Andrew S. Cowburn, Ashmore, T., Johnson, RS, Cristina Branco‐Price, James A. West, Heather, LC, Fernandez, Bernadette O, Cowburn, Andrew S, Feelisch, Martin, Ashmore, T, Martin Feelisch, Branco-Price, Cristina, Andrew J. Murray, Heather, Lisa C, Branco-Price, C, Griffin, Julian L, Cowburn, A. S., Heather, L. C., Griffin, J. L., Murray, Andrew J, Feelisch, M., Julian L. Griffin, West, J. A., Johnson, R. S., West, JA, Lisa C. Heather, Feelisch, M, Johnson, Randall S, West, James A, Griffin, JL, Murray, AJ, Fernandez, B. O., Branco-Price, C., Tom Ashmore, Cowburn, AS, Bernadette O. Fernandez, Murray, A. J., Ashmore, Tom, Randall S. Johnson   +39 more
core   +2 more sources

Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review

Journal of Neuroinflammation
Postoperative cognitive dysfunction (POCD) is a frequent neurological complication encountered during the perioperative period with unclear mechanisms and no effective treatments.
Zhenyong Zhang, Wei Yang, Lanbo Wang, Chengyao Zhu, Shuyan Cui, Tian Wang, Xi Gu, Yang Liu, Peng Qiu   +8 more
doaj   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Mitochondrial Dysfunction in Parkinson's Disease

Journal of Alzheimer's Disease, 2010
It is clear from a striking convergence of human tissue studies, neurotoxin models, and genetic models that mitochondrial dysregulation plays a central pathogenic role in Parkinson's disease (PD) and related neurodegenerative conditions. Impaired mitochondrial quality could result from both increased damage and decreased ability to repair or clear ...
Jianhui, Zhu, Charleen T, Chu
openaire   +3 more sources

Roles of Mitochondrial Dysfunction in Diabetic Kidney Disease: New Perspectives from Mechanism to Therapy

Biomolecules
Diabetic kidney disease (DKD) is a common microvascular complication of diabetes and the main cause of end-stage renal disease around the world. Mitochondria are the main organelles responsible for producing energy in cells and are closely involved in ...
Yichen Yang, Jiahui Liu, Qiling Shi, Buyu Guo, Hanbing Jia, Yuxuan Yang, Songbo Fu   +6 more
doaj   +1 more source

Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation

Redox Biology, 2019
Inflammation is a major cause of morbidity and mortality in Western societies. Despite use of multiple drugs, both chronic and acute inflammation still represent major health burdens.
Vladimir Mayorov, Peter Uchakin, Venkataraman Amarnath, Alexander V. Panov, Christy C. Bridges, Roman Uzhachenko, Bill Zackert, Christy S. Moore, Sean Davies, Anna Dikalova, Sergey Dikalov   +10 more
doaj   +1 more source

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice [PDF]

, 2012
Patients that survive hemorrhage and resuscitation (H/R) may develop a systemic inflammatory response syndrome (SIRS) that leads to dysfunction of vital organs (multiple organ dysfunction syndrome, MODS).
Zhong, Zhi, Lehnert, Mark, Marzi, Ingo, Kholmukhamedov, Andaleb, Ramshesh, Venkat K., Maldonado, Eduardo N., Lemasters, John J., Czerny, Christoph, Theruvath, Tom Prakash   +8 more
core   +1 more source