Results 111 to 120 of about 388,773 (307)

Persistent Bilateral [18F]THK5351 and Migrating Unilateral [18F]FDG Uptake in Anti‐LGI1 Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Anti–leucine‐rich glioma‐inactivated 1 encephalitis (LGI1‐E) can cause persistent cognitive deficits, but the mechanisms remain unclear. A 40‐year‐old woman with LGI1‐E presented with subacute cognitive deficits and showed mild left medial temporal lobe (MTL) swelling and fluid‐attenuated inversion recovery (FLAIR) hyperintensity on initial ...
Yusuke Akitomi, Kenichiro Taira, Masanori Kurihara, Kenji Ishibashi, Kenji Ishii, Fumio Suzuki, Aya Midori Tokumaru, Makoto Hara, Atsushi Iwata   +8 more
wiley   +1 more source

Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects

, 2015
Lilach Toker,1 Galila Agam2,3 1Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; 2Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 3Mental Health Center, Beer ...
Toker L, Agam G
core  

Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice [PDF]

, 2012
Patients that survive hemorrhage and resuscitation (H/R) may develop a systemic inflammatory response syndrome (SIRS) that leads to dysfunction of vital organs (multiple organ dysfunction syndrome, MODS).
Zhong, Zhi, Lehnert, Mark, Marzi, Ingo, Kholmukhamedov, Andaleb, Ramshesh, Venkat K., Maldonado, Eduardo N., Lemasters, John J., Czerny, Christoph, Theruvath, Tom Prakash   +8 more
core   +1 more source

Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review

Journal of Neuroinflammation
Postoperative cognitive dysfunction (POCD) is a frequent neurological complication encountered during the perioperative period with unclear mechanisms and no effective treatments.
Zhenyong Zhang, Wei Yang, Lanbo Wang, Chengyao Zhu, Shuyan Cui, Tian Wang, Xi Gu, Yang Liu, Peng Qiu   +8 more
doaj   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Mitochondrial Dysfunction in Parkinson's Disease

Journal of Alzheimer's Disease, 2010
It is clear from a striking convergence of human tissue studies, neurotoxin models, and genetic models that mitochondrial dysregulation plays a central pathogenic role in Parkinson's disease (PD) and related neurodegenerative conditions. Impaired mitochondrial quality could result from both increased damage and decreased ability to repair or clear ...
Jianhui, Zhu, Charleen T, Chu
openaire   +3 more sources

Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation

Redox Biology, 2019
Inflammation is a major cause of morbidity and mortality in Western societies. Despite use of multiple drugs, both chronic and acute inflammation still represent major health burdens.
Vladimir Mayorov, Peter Uchakin, Venkataraman Amarnath, Alexander V. Panov, Christy C. Bridges, Roman Uzhachenko, Bill Zackert, Christy S. Moore, Sean Davies, Anna Dikalova, Sergey Dikalov   +10 more
doaj   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus

, 2020
Mitochondrial dysfunction is known to occur in diabetic phenotypes including type 1 and 2 diabetes mellitus. The incidence of Gestational diabetes mellitus (GDM) is increasing and defined as the onset of a diabetic phenotype during pregnancy. The role of
James S. M. Cuffe, Joshua J. Fisher, Bartho, Lucy A, Fisher, Joshua J., Holland, Olivia. J., Vanderpeet, Chelsea L., Lucy A. Bartho, Perkins, Anthony V, Cuffe, James S. M., Perkins, Anthony V., Holland, Olivia J, Daniel R. McKeating, McKeating, Daniel R., Bartho, Lucy A., Anthony V. Perkins, Olivia. J. Holland, Cuffe, James SM, Fisher, Joshua J, Chelsea L. Vanderpeet, Vanderpeet, Chelsea L, McKeating, Daniel R   +20 more
core   +1 more source

Mitochondrial dysfunction and its role in tissue-specific cellular stress [PDF]

, 2018
Mitochondrial bioenergetics require the coordination of two different and independent genomes. Mutations in either genome will affect mitochondrial functionality and produce different sources of cellular stress. Depending on the kind of defect and stress,
Markus Deckers, Deckers, Markus, Pacheu-Grau, David, Rucktaeschel, Robert, Robert Rucktäschel, David Pacheu-Grau   +5 more
core   +1 more source