Mitochondrial Dysfunction in Aging and Diseases of Aging. [PDF]
, 2019 Mitochondria have been increasingly recognized as the important players in the aging process [...]
Haas, Richard H
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Mitochondrial Dysfunction in Cancer [PDF]
Frontiers in Oncology, 2013 A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its significance for clinical management of cancer. Work discussed in this review focuses less on the Warburg effect and more on mitochondria and how dysfunctional
Boland, Michelle L. +2 more
openaire +3 more sources
Advances in exercise to alleviate sarcopenia in older adults by improving mitochondrial dysfunction
Frontiers in Physiology, 2023 Sarcopenia is a chronic degenerative disease affecting primarily older adults. A growing aging population is gradually increasing the number of patients suffering from sarcopenia, placing increasing financial pressure on patients’ families and society in
Yang Zhu +5 more
doaj +1 more source
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]
, 2009 Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander +42 more
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Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway. [PDF]
PLoS ONE, 2016 Mitochondrial dysfunction plays a key role in the progression of Alzheimer's disease (AD). The accumulation of amyloid-beta peptide (Aβ) in the brains of AD patients is thought to be closely related to neuronal mitochondrial dysfunction and oxidative ...
Chunhui Zhao +7 more
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Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene [PDF]
, 2006 In the present study we confirm the previously reported high frequency of biochemical markers of mitochondrial dysfunction, namely hyperlactacidemia and increased lactate/pyruvate ratio, in a significant fraction of 210 autistic patients.
Almeida, J. +11 more
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A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]
, 2017 Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco +15 more
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Mitochondrial Regulation of Diabetic Kidney Disease
Frontiers in Medicine, 2021 The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood.
Daniel L. Galvan +4 more
doaj +1 more source
Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. [PDF]
, 2015 Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by ...
de la Cruz, Aida Flor A +3 more
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Mitochondrial dysfunction in heart failure and its therapeutic implications
Frontiers in Cardiovascular Medicine, 2022 The ATP consumption in heart is very intensive to support muscle contraction and relaxation. Mitochondrion is the power plant of the cell. Mitochondrial dysfunction has long been believed as the primary mechanism responsible for the inability of energy ...
Miaosen Liu +5 more
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