Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines
Scientific Reports, 2022 Mitochondrial dysfunction promotes cancer aggressiveness, metastasis, and resistance to therapy. Similar traits are associated with epithelial mesenchymal transition (EMT).
Maria do Carmo Greier +6 more
doaj +1 more source
The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis
Cells, 2022 Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing evidence suggests that a key contributing factor is mitochondrial dysfunction ...
Jiantao Zhao +13 more
semanticscholar +1 more source
Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. [PDF]
, 2008 The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes.
Hao, Jiejie +8 more
core +1 more source
The multifaceted roles of natural products in mitochondrial dysfunction
Frontiers in Pharmacology, 2023 Mitochondria are the primary source of energy production in cells, supporting the metabolic demand of tissue. The dysfunctional mitochondria are implicated in various diseases ranging from neurodegeneration to cancer.
Qianrun Chen +4 more
doaj +1 more source
Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]
, 2016 Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano +3 more
core +2 more sources
Mitochondrial Dysfunction Meets Senescence [PDF]
Trends in Biochemical Sciences, 2016 Cellular senescence and mitochondrial dysfunction are hallmarks of ageing, but until now their relationship has not been clear. Recent work by Wiley et al. shows that mitochondrial defects can cause a distinct senescence phenotype termed MiDAS (mitochondrial dysfunction-associated senescence).
Suchira, Gallage, Jesús, Gil
openaire +2 more sources
Recent advances and new perspectives in mitochondrial dysfunction
Scientific Reports, 2023 In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction.
Cecilia Giulivi +2 more
doaj +1 more source
Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]
, 2016 Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F. +4 more
core +1 more source
Mitochondrial Dysfunction in Metabolic Disease
Indonesian Biomedical Journal, 2012 BACKGROUND: Mitochondrial function and behavior are central to the physiology of humans and, consequently, "mitochondrial dysfunction" has been implicated in a wide range of disease.
Anna Meiliana, Andi Wijaya
doaj +1 more source
Mitochondrial Dysfunction and Oxidative Stress Caused by Cryopreservation in Reproductive Cells
Antioxidants, 2021 Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell death.
R. Gualtieri +5 more
semanticscholar +1 more source