Results 181 to 190 of about 41,598 (256)

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, Volume 46, Issue 4, Page 1076-1082, April 2026.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity. [PDF]

Nat Commun
Voos KM, Tzeng J, Patel P, Rubinsky S, Choi HE, Pharr T, Sookram S, Baur JA, Soderblom EJ, Lorenzo DN.   +9 more
europepmc   +1 more source

Molecular Machinery of Mitochondrial Fusion and Fission [PDF]

Journal of Biological Chemistry, 2008
openaire   +2 more sources

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Mitochondrial fission genes MTFP1/MTFP2 as predictive biomarkers in prostate cancer: a mendelian randomization study. [PDF]

Discov Oncol
Huangfu X, Fan Z, Zheng J, Xie J.
europepmc   +1 more source

Clostridioides difficile‐Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Clostridioides difficile (CD) is a leading cause of antibiotic‐associated diarrhoea in both hospitalized and non‐hospitalized patients. This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strain 630 (CD630‐EVs), which released spherical EVs during in vitro culture, in modulating pro‐inflammatory ...
Fangfang Fan, Yu Zeng, Qianli Zhao, Tongxuan Su, Yining Shen, Wei Chen, Cen Jiang, Qi Ni, Yiyue Liu, Ru Fan, Danfeng Dong, Yibing Peng   +11 more
wiley   +1 more source

Pioglitazone Ameliorates Mitochondrial Oxidative Stress and Inflammation via AMPK-Dependent Inhibition of Mitochondrial Fission in Leigh Syndrome. [PDF]

Cell Prolif
Luo J, Chen L, Zhang X, Su Q, Zhou X, Lian Q.   +5 more
europepmc   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Mitochondrial fission - changing perspectives for future progress.

J Cell Sci
Kamerkar SC, Liu A, Higgs HN.
europepmc   +1 more source