Results 241 to 250 of about 34,614 (273)
miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor [PDF]
Free Radical Biology and Medicine, 2013 Mitochondria are dynamic organelles that constantly undergo fission and fusion. The balance between fission and fusion determines the fate of the cell. In this study, we show that mitochondrial fission factor (MFF) is upregulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury.
Bo Long, Iram Murtaza, Cui-Yun Liu
exaly +3 more sources
The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy [PDF]
International Journal of Molecular Sciences, 2023 Mitochondria, the membrane-bound cell organelles that supply most of the energy needed for cell function, are highly regulated, dynamic organelles bearing the ability to alter both form and functionality rapidly to maintain normal physiological events ...
Nir Qvit, Qvit Nir
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The role of mitochondrial fission factor in podocyte injury in diabetic nephropathy
Biochemical and Biophysical Research Communications, 2022Diabetic nephropathy (DN) is one of the most important complications of diabetes mellitus (DM) and has become the second cause of end-stage renal disease (ESRD). This study intends to investigate the molecular mechanism of increased mitochondrial fission in podocytes under the effect of high glucose (HG), and to preliminarily study the role of ...
Min Xiao +9 more
openaire +2 more sources
Clinical and Experimental Pharmacology and Physiology, 2018
SummaryMitochondrial dysfunction contributes to the pathogenesis of cardiac hypertrophy. The disequilibrium of mitochondrial dynamic, which refers to mitochondrial fusion and fission, leads to mitochondrial morphology alteration and dysfunction. Enhanced understanding of the molecular mechanisms in depth may shed light on the therapy of the disease. In
Yong Le Sun +3 more
openaire +2 more sources
SummaryMitochondrial dysfunction contributes to the pathogenesis of cardiac hypertrophy. The disequilibrium of mitochondrial dynamic, which refers to mitochondrial fusion and fission, leads to mitochondrial morphology alteration and dysfunction. Enhanced understanding of the molecular mechanisms in depth may shed light on the therapy of the disease. In
Yong Le Sun +3 more
openaire +2 more sources
Circulation, 2023
Introduction: The obstructive vasculopathy in pulmonary arterial hypertension (PAH) results from unrestricted proliferation and impaired apoptosis of pulmonary artery smooth muscle cells (PASMC). This pseudoneoplastic phenotype is partly due to increased mitotic fission i.e.
Pierce Colpman +5 more
openaire +1 more source
Introduction: The obstructive vasculopathy in pulmonary arterial hypertension (PAH) results from unrestricted proliferation and impaired apoptosis of pulmonary artery smooth muscle cells (PASMC). This pseudoneoplastic phenotype is partly due to increased mitotic fission i.e.
Pierce Colpman +5 more
openaire +1 more source
Diabetes, 2023
Nonalcoholic fatty liver disease (NAFLD) develops into nonalcoholic steatohepatitis (NASH) when fat accumulates in the liver, leading to hepatocyte apoptosis, inflammation and fibrosis. No effective treatments for NASH have been established. Mitochondria are important organelles that play a central role in de novo lipogenesis and fatty acid β-oxidation.
YUKINA TAKEICHI +2 more
openaire +1 more source
Nonalcoholic fatty liver disease (NAFLD) develops into nonalcoholic steatohepatitis (NASH) when fat accumulates in the liver, leading to hepatocyte apoptosis, inflammation and fibrosis. No effective treatments for NASH have been established. Mitochondria are important organelles that play a central role in de novo lipogenesis and fatty acid β-oxidation.
YUKINA TAKEICHI +2 more
openaire +1 more source
Nature Cell Biology, 2009
Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. The physiological importance of mitochondrial fission in vertebrates is less clearly defined than that of mitochondrial fusion. Here we show that mice lacking the mitochondrial fission GTPase Drp1 have developmental abnormalities, particularly in the forebrain ...
Naotada, Ishihara +15 more
openaire +2 more sources
Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. The physiological importance of mitochondrial fission in vertebrates is less clearly defined than that of mitochondrial fusion. Here we show that mice lacking the mitochondrial fission GTPase Drp1 have developmental abnormalities, particularly in the forebrain ...
Naotada, Ishihara +15 more
openaire +2 more sources
2022
Parkinson disease (PD) is the second most common neurodegenerative disorder and is strongly associated with the accumulation of Lewy bodies and loss of dopaminergic (DA) neurons in the substantia nigra of brain. The pathophysiology includes bradykinesia, tremors, motor, autonomic and cognitive disorders.
openaire +1 more source
Parkinson disease (PD) is the second most common neurodegenerative disorder and is strongly associated with the accumulation of Lewy bodies and loss of dopaminergic (DA) neurons in the substantia nigra of brain. The pathophysiology includes bradykinesia, tremors, motor, autonomic and cognitive disorders.
openaire +1 more source
Biochemical and Biophysical Research Communications, 2012
Mitochondria play a critical role in regulation of apoptosis, a form of programmed cell death, by releasing apoptogenic factors including cytochrome c. Growing evidence suggests that dynamic changes in mitochondrial morphology are involved in cellular apoptotic response.
Akane, Inoue-Yamauchi, Hideaki, Oda
openaire +2 more sources
Mitochondria play a critical role in regulation of apoptosis, a form of programmed cell death, by releasing apoptogenic factors including cytochrome c. Growing evidence suggests that dynamic changes in mitochondrial morphology are involved in cellular apoptotic response.
Akane, Inoue-Yamauchi, Hideaki, Oda
openaire +2 more sources
Biochemical and Biophysical Research Communications, 2003
The mitochondrial fusion factors mitofusins 1 and 2 (Mfn1 and Mfn2) and the fission factor dynamin-related protein 1 (Drp1) were found to be highly expressed in the pubertal and adult rat testis by Northern blot analysis. Immunohistochemistry using specific antisera to Mfn2 and Drp1 revealed a pronounced expression of the fusion and fission factors in ...
Honda, S., Hirose, S.
openaire +2 more sources
The mitochondrial fusion factors mitofusins 1 and 2 (Mfn1 and Mfn2) and the fission factor dynamin-related protein 1 (Drp1) were found to be highly expressed in the pubertal and adult rat testis by Northern blot analysis. Immunohistochemistry using specific antisera to Mfn2 and Drp1 revealed a pronounced expression of the fusion and fission factors in ...
Honda, S., Hirose, S.
openaire +2 more sources