Results 121 to 130 of about 156,551 (297)

Mitochondrial β-amyloid in Alzheimer's disease

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Conway, SJ, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway   +20 more
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Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Fish oil and omega3 in the prevention of metabolic disorders linked to obesity: role of mitochondrial function

, 2011
Obesity is one of the most serious public health problems of the 21st century. Along with the increase in obesity, there is a parallel increase in the prevalence of type 2 diabetes, impaired glucose tolerance, atherogenic dyslipidemia (high plasma ...
Pignalosa, Angelica
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Mechanisms of Mitochondrial Fusion and Fission [PDF]

, 2006
We have studied the mechanisms of mitochondrial fusion and fission in S. cerevisiae. Using a proteomics-based approach, we have identified the WD domain protein Caf4p as a Fis1p binding partner that, along with its paralog Mdv1p, functions as a ...
Griffin, Erik Edmund
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

A study of mitochondrial biogenesis in the rodent nervous system

, 2015
This thesis investigates the process of mitochondrial biogenesis in the rodent CNS in the context of neuroinflammatory and neurodegenerative disease. There is mounting evidence of mitochondrial damage in neuroinflammation but very little is known about ...
Desai, R
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Anomalous diffusion induced by cristae geometry in the inner mitochondrial membrane

, 2009
Diffusion of inner membrane proteins is a prerequisite for correct functionality of mitochondria. The complicated structure of tubular, vesicular or flat cristae and their small connections to the inner boundary membrane impose constraints on the ...
Jürgen Bereiter-Hahn, Sukhorukov Valerii M., Sukhorukov, Valerii M., Valerii M Sukhorukov, Bereiter-Hahn Jürgen, Bereiter-Hahn, Jürgen, Valerii M. Sukhorukov   +6 more
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Multi-patterned dynamics of mitochondrial fission and fusion in a living cell.

, 2012
Mitochondria are highly-dynamic organelles, but it is challenging to monitor quantitatively their dynamics in a living cell. Here we developed a novel approach to determine the global occurrence of mitochondrial fission and fusion events in living human ...
Lu, Shouqin, Chen, Ming, Shan Sicong, Quan Chen (163802), Zhang, Yan, Chen, Quan, Chuanmao Zhang, Chunsun Jiang (163786), Xiao, Weiming, Chen Juan, Long, Mian, Shan, Sicong, Shiqi Wang, Chen M, Lü Shouqin, Zhang, Chuanmao, Juan Chen, Chen Ming, Chen Quan, Yan Zhang, Mian Long, Weiming Xiao (163778), Ming Chen, Sicong Shan, 王世骐, Jiang, Chunsun, 吕守芹, Wang, SQ, 龙勉, Zhang Yan, 陈娟, 单思聪, Wang, Shiqi, Ming Chen (115604), Zhang CM, Wang Shiqi, Xiao WM, Shouqin Lü, Mian Long (163806), Yan Zhang (8098), Jiang Chunsun, Chunsun Jiang, Quan Chen, Zhang Chuanmao, Weiming Xiao, Juan Chen (61123), Jiang CS, Sicong Shan (163783), Long Mian, Chuanmao Zhang (163797), Shiqi Wang (163773), Chinese Acad Sci, Natl Micrograv Lab, Key Lab Micrograv, Beijing, Peoples R China., Shouqin Lü (163792), Xiao Weiming, 章燕, Chen, Juan   +55 more
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